公开(公告)号：US20150218182A1

公开(公告)日：2015-08-06

申请号：US14236428

申请日：2012-08-02

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： Adam Zlotnick ,  M.G. Finn

IPC: C07D491/113 ,  C07D401/12 ,  C07D401/14 ,  C07D471/04 ,  C07D401/04

CPC classification number: C07D493/10 ,  A61K31/496 ,  C07D239/20 ,  C07D239/22 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D417/04 ,  C07D471/04 ,  C07D491/10 ,  C07D491/113

Abstract: In addition to containing and protecting the viral genome, the capsid (protein shell) of hepatitis B virus (HBV) plays critical roles in the viral life cycle including regulation of intracellular trafficking and nucleic acid metabolism. Substituted pyrimidine modulators of the assembly of the HBV capsid structure and methods for their use are described.

Abstract translation: 除了含有和保护病毒基因组外，乙型肝炎病毒（HBV）的衣壳（蛋白质外壳）在病毒生命周期中起关键作用，包括调节细胞内运输和核酸代谢。 描述了HBV衣壳结构组装的取代嘧啶调节剂及其使用方法。

公开(公告)号：US20170226121A1

公开(公告)日：2017-08-10

申请号：US15287593

申请日：2016-10-06

Applicant: Indiana University Research and Technology Corporation ,  Scripps Research Institute, A Not-for-Profit Public Benefit Corporation of California

Inventor： Adam Zlotnick ,  M.G. Finn

IPC: C07D493/10 ,  C07D417/04 ,  C07D401/14 ,  C07D401/12 ,  C07D491/113 ,  C07D471/04 ,  C07D239/22 ,  C07D401/04 ,  C07D239/20

CPC classification number: C07D493/10 ,  A61K31/496 ,  C07D239/20 ,  C07D239/22 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D417/04 ,  C07D471/04 ,  C07D491/10 ,  C07D491/113

Abstract: In addition to containing and protecting the viral genome, the capsid (protein shell) of hepatitis B virus (HBV) plays critical roles in the viral life cycle including regulation of intracellular trafficking and nucleic acid metabolism. Substituted pyrimidine modulators of the assembly of the HBV capsid structure and methods for their use are described.