公开(公告)号：US20190218268A1

公开(公告)日：2019-07-18

申请号：US16098236

申请日：2017-05-31

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： Richard D. DIMARCHI ,  John P. MAYER ,  Piotr MROZ

IPC: C07K14/605 ,  A61P3/10 ,  A61K38/26 ,  A61K38/28

Abstract: Modified glucagon peptides are disclosed having improved solubility and/or stability while retaining glucagon agonist activity. The glucagon peptides have been modified by the substitution of pyridyl-alanine for a native amino acid at one or more of positions 6, 10 or 13 and/or substitution with an amino acid in the D-conformation at position 20 or 21 compared to native glucagon.