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公开(公告)号：US20190218268A1
公开(公告)日：2019-07-18
申请号：US16098236
申请日：2017-05-31
Inventor： Richard D. DIMARCHI , John P. MAYER , Piotr MROZ
IPC: C07K14/605 , A61P3/10 , A61K38/26 , A61K38/28
Abstract: Modified glucagon peptides are disclosed having improved solubility and/or stability while retaining glucagon agonist activity. The glucagon peptides have been modified by the substitution of pyridyl-alanine for a native amino acid at one or more of positions 6, 10 or 13 and/or substitution with an amino acid in the D-conformation at position 20 or 21 compared to native glucagon.
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公开(公告)号：US20170283479A1
公开(公告)日：2017-10-05
申请号：US15513762
申请日：2015-09-23
Inventor： Richard D. DIMARCHI , Binbin KOU , Fa ZHANG , John P. MAYER
CPC classification number: C07K14/62 , A61K38/00 , A61K38/28 , A61K47/00 , A61K47/54 , A61K47/543 , A61K47/6911
Abstract: Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug element. The prodrugs disclosed herein have extended half-lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.
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公开(公告)号：US20170281788A1
公开(公告)日：2017-10-05
申请号：US15513748
申请日：2015-09-23
Inventor： Richard D. DIMARCHI , John P. MAYER , David L. SMILEY , Fa LIU
IPC: A61K47/48 , A61K38/28 , C07K19/00 , A61K38/22 , C07K14/575
CPC classification number: A61K38/22 , A61K9/0019 , A61K9/0024 , A61K38/00 , A61K38/28 , A61K47/02 , A61K47/545 , A61K47/64 , C07K2/00 , C07K14/575 , C07K14/605 , C07K14/62
Abstract: Disclosed herein are insulin agonist peptides conjugated to incretins wherein the incretin-insulin conjugate has agonist activity at the insulin receptor and the corresponding incretin receptor, and stimulates weight loss in an individual administered the compound.
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