公开(公告)号：US10683334B2

公开(公告)日：2020-06-16

申请号：US16098236

申请日：2017-05-31

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： Richard D. Dimarchi ,  John P. Mayer ,  Piotr Mroz

IPC: A61K38/26 ,  C07K14/605 ,  A61K38/28 ,  A61P3/10

Abstract: Modified glucagon peptides are disclosed having improved solubility and/or stability while retaining glucagon agonist activity. The glucagon peptides have been modified by the substitution of pyridyl-alanine for a native amino acid at one or more of positions 6, 10 or 13 and/or substitution with an amino acid in the D-conformation at position 20 or 21 compared to native glucagon.