公开(公告)号：US20030113379A1

公开(公告)日：2003-06-19

申请号：US10219674

申请日：2002-08-16

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Da-Young Chen ,  Huey-Min Lai ,  Yuan-Han Chen ,  Rung-Jiun Gau

IPC: A61K031/66 ,  A61K009/14

CPC classification number: A61L27/48 ,  A61K31/00 ,  A61L27/58

Abstract: A biodegradable composite matrix for enhancing angiogenesis. The matrix includes a biodegradable material and a phospholipid distributed in the biodegradable material as a liposome or micelle. Derivatives of phospholipid have chemo-attraction properties and thus induce the transfer of endothelial cells into the system through tropism-inductive mechanism. The biodegradable composite matrix induces an intracellular signal cascade that is different from cascade induced by a growth factor, and can coordinate with the growth factor-induced cascade to enhance angiogenesis. The present invention also includes the method for producing the biodegradable composite matrix.

Abstract translation: 用于增强血管发生的可生物降解的复合基质。 该基质包括分解在生物可降解材料中的可生物降解材料和磷脂作为脂质体或胶束。 磷脂的衍生物具有化学吸引性，因此通过向性诱导机制诱导内皮细胞向系统的转移。 可生物降解的复合基质诱导与生长因子诱导的级联不同的细胞内信号级联，并且可以与生长因子诱导的级联配合以增强血管发生。 本发明还包括生物可降解复合基质的制造方法。