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    Biodegradable composite matrix for enhancing angiogenesis and method for producing the same
    3.
    发明申请
    Biodegradable composite matrix for enhancing angiogenesis and method for producing the same 审中-公开
    用于增强血管生成的生物可降解复合基质及其制备方法

    公开(公告)号：US20030113379A1

    公开(公告)日：2003-06-19

    申请号：US10219674

    申请日：2002-08-16

    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

    Inventor： Da-Young Chen ,  Huey-Min Lai ,  Yuan-Han Chen ,  Rung-Jiun Gau

    IPC: A61K031/66 ,  A61K009/14

    CPC classification number: A61L27/48 ,  A61K31/00 ,  A61L27/58

    Abstract: A biodegradable composite matrix for enhancing angiogenesis. The matrix includes a biodegradable material and a phospholipid distributed in the biodegradable material as a liposome or micelle. Derivatives of phospholipid have chemo-attraction properties and thus induce the transfer of endothelial cells into the system through tropism-inductive mechanism. The biodegradable composite matrix induces an intracellular signal cascade that is different from cascade induced by a growth factor, and can coordinate with the growth factor-induced cascade to enhance angiogenesis. The present invention also includes the method for producing the biodegradable composite matrix.

    Abstract translation: 用于增强血管发生的可生物降解的复合基质。 该基质包括分解在生物可降解材料中的可生物降解材料和磷脂作为脂质体或胶束。 磷脂的衍生物具有化学吸引性，因此通过向性诱导机制诱导内皮细胞向系统的转移。 可生物降解的复合基质诱导与生长因子诱导的级联不同的细胞内信号级联，并且可以与生长因子诱导的级联配合以增强血管发生。 本发明还包括生物可降解复合基质的制造方法。

    Biodegradable porous devices for tissue engineering
    4.
    发明申请
    Biodegradable porous devices for tissue engineering 审中-公开
    用于组织工程的生物可降解多孔装置

    公开(公告)号：US20030072790A1

    公开(公告)日：2003-04-17

    申请号：US09982565

    申请日：2001-10-16

    Applicant: Industrial Technology Research Institute

    Inventor： Chin-Chin Tsai ,  Hsi-Hsin Shih ,  Huey-Min Lai

    IPC: A61K009/70 ,  D04H013/00

    CPC classification number: A61L27/58 ,  A61L27/48 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/604 ,  Y10T442/608

    Abstract: A biodegradable porous device for tissue engineering is disclosed, which comprises (A) a porous polymeric scaffold comprising a co-continuous phase of a first biodegradable polymer and a second biodegradable polymer which are incompatible with each other, wherein the first biodegradable polymer contains a continuous network of large, interconnected pores, and the second biodegradable polymer contains small, partially interconnected pores; (B) a biodegradable polymer fiber dispersed in, and compatible with the matrix of the first biodegradable polymer; and optionally (C) an active ingredient provided in the polymeric scaffold.

    Abstract translation: 公开了用于组织工程的可生物降解的多孔装置，其包括（A）包含彼此不相容的第一可生物降解聚合物和第二可生物降解聚合物的共连续相的多孔聚合物支架，其中所述第一可生物降解聚合物包含连续 大的相互连通的孔的网络，第二可生物降解的聚合物包含小的部分互连的孔; （B）分散在第一可生物降解的聚合物基质中并与其相容的可生物降解的聚合物纤维; 和任选地（C）在聚合物支架中提供的活性成分。

    Preparation of a biodegradable thermal-sensitive gel system
    5.
    发明申请
    Preparation of a biodegradable thermal-sensitive gel system 审中-公开
    制备可生物降解的热敏凝胶体系

    公开(公告)号：US20040013733A1

    公开(公告)日：2004-01-22

    申请号：US10330085

    申请日：2002-12-30

    Applicant: Industrial Technology Research Institute

    Inventor： Yuan-Han Chen ,  Ming-Hsi Yeh ,  Huey-Min Lai

    IPC: A61K038/39 ,  A61K031/737 ,  A61K031/716 ,  A61K009/14

    CPC classification number: A61K9/0024 ,  A61K47/36 ,  A61L27/26 ,  A61L27/52 ,  C08L89/06 ,  C08L5/08

    Abstract: The present invention relates to a biodegradable thermal-sensitive gel system, which comprises at least one polysaccharide solution, at least one electrolytic salt, and at least one buffer solution for adjusting pH. A natural protein as well as a cross-linking agent can be added to the gel system optionally. Said gel system is liquid at room temperature (25null C.) and solidifies at or above 37null C. The present invention also relates to a process for preparing said gel system, and a use for drug releasing carrier.

    Abstract translation: 本发明涉及一种可生物降解的热敏凝胶体系，其包含至少一种多糖溶液，至少一种电解质盐和至少一种用于调节pH的缓冲溶液。 天然蛋白质以及交联剂可以任选地添加到凝胶体系中。 所述凝胶体系在室温（25℃）下为液体，并在37℃或更高温度下固化。本发明还涉及制备所述凝胶体系的方法和用于药物释放载体的用途。

    Method of making porous biodegradable polymers
    6.
    发明申请
    Method of making porous biodegradable polymers 失效
    制造多孔生物可降解聚合物的方法

    公开(公告)号：US20030064156A1

    公开(公告)日：2003-04-03

    申请号：US09947182

    申请日：2001-09-04

    Applicant: Industrial Technology Research Institute

    Inventor： Hsi-Hsin Shih ,  Kuang-Rong Lee ,  Huey-Min Lai ,  Chin-Chin Tsai ,  Yuan-Chia Chang

    IPC: B05D003/10

    CPC classification number: C08J9/122 ,  A61L27/56 ,  A61L27/58 ,  C08J2201/032 ,  C08J2203/06 ,  C08J2203/08 ,  C08J2389/00 ,  Y02P20/544

    Abstract: A method of making a porous biodegradable polymer is disclosed, which comprises (a) placing a biodegradable polymer and a solvent in a chamber; (b) adding a supercritical fluid to the chamber and maintaining the chamber at a predetermined temperature for a sufficient period of time to allow the supercritical fluid to dissolve into the biodegradable polymer with the help of the solvent; and (c) venting the supercritical fluid and the solvent by reducing the pressure in the chamber, thereby obtaining a porous biodegradable polymer.

    Abstract translation: 公开了制备多孔生物可降解聚合物的方法，其包括（a）将可生物降解的聚合物和溶剂置于室中; （b）将超临界流体加入到室中并将室维持在预定温度足够的时间以允许超临界流体借助溶剂溶解到可生物降解的聚合物中; 和（c）通过降低室中的压力来排出超临界流体和溶剂，从而获得多孔生物可降解聚合物。

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