公开(公告)号：US20220202952A1

公开(公告)日：2022-06-30

申请号：US17560820

申请日：2021-12-23

Applicant: Industrial Technology Research Institute

Inventor： Neng-Chang YU ,  Felice CHENG ,  Chih-Peng LIU ,  Ming-Hsi WU ,  Shih-Ta CHEN ,  Chia-Mu TU ,  Li-Wen CHANG ,  Jheng-Sian LI ,  Meng-Ping SHE ,  Hsiang-Ching WANG

IPC: A61K47/69 ,  A61K31/7105 ,  A61K31/711 ,  A61K39/395 ,  A61P35/00

Abstract: An immunostimulatory lipoplex is provided. The immunostimulatory lipoplex includes a liposome and at least one immunostimulatory nucleic acid drug, and the immunostimulatory nucleic acid drug is complexed with the liposome The liposome includes 40 to 85 mol % of cationic lipid, 10 to 50 mol % of cholesterol, and 0.001 to 20 mol % of modified polyethylene glycol lipid. A pharmaceutical composition including the immunostimulatory lipoplex is also provided

公开(公告)号：US20160361268A1

公开(公告)日：2016-12-15

申请号：US15142170

申请日：2016-04-29

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Chih-Peng LIU ,  Ya-Chin LO ,  Ming-Cheng WEI ,  Maggie LU ,  Shuen-Hsiang CHOU ,  Shih-Ta CHEN ,  Hsiang-Wen TSENG

IPC: A61K9/51 ,  A61K33/24 ,  A61K9/00 ,  A61K31/282

CPC classification number: A61K9/5161 ,  A61K9/0019 ,  A61K31/555 ,  A61K33/24

Abstract: Disclosed is an intralymphatic delivery method for treating lymphatic cancer using hyaluronan nanoparticles. These nanoparticles include a hyaluronic acid derivative and a platinum compound. The hyaluronan derivative includes hyaluronic acid, modified histidine and optionally one or more of a polymer or a C4-C20 alkyl. The hyaluronic acid derivative may include linking group(s) that connect the polymer or the C4-C20 alkyl to the hyaluronic acid. The platinum compound includes dichloro(1,2-diaminocyclohexane) platinum (DACHPt), cisplatin and oxaliplatin. This intralymphatic delivery method offers significant advantages for the use of platinum medicines in treating lymphatic cancer.

Abstract translation: 公开了使用透明质酸纳米颗粒治疗淋巴癌的淋巴内递送方法。 这些纳米颗粒包括透明质酸衍生物和铂化合物。 透明质酸衍生物包括透明质酸，修饰的组氨酸和任选的一种或多种聚合物或C 4 -C 20烷基。 透明质酸衍生物可以包括连接聚合物或C4-C20烷基与透明质酸的连接基团。 铂化合物包括二氯（1,2-二氨基环己烷）铂（DACHPt），顺铂和奥沙利铂。 这种淋巴内递送方法在使用铂药物治疗淋巴癌方面具有显着的优势。

公开(公告)号：US20210230600A1

公开(公告)日：2021-07-29

申请号：US17132793

申请日：2020-12-23

Applicant: Industrial Technology Research Institute

Inventor： Ping-Fu CHENG ,  Ya-Ling CHIU ,  Kang-Li WANG ,  Po-Yen LIN ,  Shih-Ta CHEN ,  Tseng-Huang LIU ,  Pei-Shin JIANG

IPC: C12N15/115 ,  C12N15/113 ,  A61K47/54 ,  A61K9/00 ,  A61P35/00

Abstract: A nucleic acid-drug complex is provided in the present disclosure, which includes a nucleic acid sequence of an anti-PD-L1 aptamer and a CpG oligonucleotide sequence capable of activating TLR9, in which the CpG oligonucleotide sequence consists of a first fragment and a second fragment, and the nucleic acid sequence of the anti-PD-L1 aptamer is inserted between the first fragment and the second fragment.