公开(公告)号：US11246822B2

公开(公告)日：2022-02-15

申请号：US16730564

申请日：2019-12-30

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Ting-Yu Shih ,  Lu-Chih Wang ,  Yuan-Kun Yu ,  Yi-Ting Hsieh ,  Yu-Chun Liu ,  Jing-Wen Tang

IPC: A61K8/00 ,  A61K8/73 ,  A61K8/06 ,  A61K8/49 ,  A61Q19/08 ,  A61K8/04 ,  A61K9/107 ,  A61K31/728 ,  A61K9/00 ,  A61K31/4172 ,  A61K31/375 ,  A61K8/67 ,  A61K31/015 ,  A61K8/02 ,  A61K8/96

Abstract: A method for skin care and/or maintenance including applying or administering a preparation to a subject is provided. The preparation includes a biomedical composition, and the biomedical composition includes an effective amount of micelle, wherein the micelle includes a hyaluronic acid and/or a derivative thereof and a modified histidine. The modified histidine is grafted to at least one primary hydroxyl group of the hyaluronic acid and/or the derivative thereof, and a graft ratio of the modified histidine is 1-100%. Moreover, the hyaluronic acid and/or the derivative thereof and the modified histidine form the micelle on a weight percentage of 0.2-300:1.

公开(公告)号：US11629213B2

公开(公告)日：2023-04-18

申请号：US17133872

申请日：2020-12-24

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Ting-Yu Shih ,  Chia-Chun Wang ,  Lu-Chih Wang ,  Yuan-Kun Yu ,  Shu-Fang Chiang ,  Yi-Ting Hsieh ,  Yu-Chun Liu ,  Jing-Wen Tang

IPC: C08F285/00 ,  C08F283/06

Abstract: A graft polymer is provided, which includes a polymer backbone with a plurality of hydroxy groups, protection group modified histidine grafted onto the side of the polymer backbone, and hydrophilic polymer having terminal reactive group grafted onto the side of the polymer backbone. The graft polymer coating can be applied to metal material to form a composite material, which can be implanted into an organism to reduce adhesion problems.