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公开(公告)号：US12128585B2
公开(公告)日：2024-10-29
申请号：US16976413
申请日：2019-03-26
发明人： Eun Pyo Choi , Jong Oh Park , Chang Sei Kim , Byung Jeon Kang , Seok Jae Kim , Gwang Jun Go , Yeong Jun Chang
IPC分类号： B01J2/04 , B29C31/02 , B29C31/04 , B29C67/20 , C08J9/00 , A61L27/26 , A61L27/56 , B29K105/04 , C08J9/26
CPC分类号： B29C31/04 , B01J2/04 , B29C31/02 , B29C67/202 , C08J9/0061 , A61L27/26 , A61L27/56 , B29K2105/041 , C08J9/26 , C08J2205/044 , C08J2329/04 , C08J2367/04 , C08J2389/00 , A61L27/26 , C08L67/04 , A61L27/26 , C08L29/04 , A61L27/26 , C08L89/06
摘要： The present invention relates to a manufacturing device for manufacturing a large amount of micro-scaffolds for a long period of time such that stable and uniform particles can be fabricated. The manufacturing device comprises: a first solution storage portion for storing a polymer support structure solution; a second solution storage portion for storing an emulsifier solution; a gas storage portion connected to each of the first solution storage portion and the second solution storage portion; a pressure control portion for controlling the pressure of the transporting gas flowing into the first solution storage portion and the second solution storage portion from the pressurization portion, respectively; a scaffold injector portion for receiving the polymer support structure solution and the emulsifier solution provided by the transporting gas, respectively; and a scaffold generating portion for receiving the scaffold dispersion discharged through the scaffold injection portion.
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公开(公告)号：US12070290B2
公开(公告)日：2024-08-27
申请号：US17059597
申请日：2019-03-21
发明人： Chang Sei Kim , Jong Oh Park , Eun Pyo Choi , Byung Jeon Kang , Kim Tien Nguyen , Gwang Jun Go
CPC分类号： A61B34/73 , A61B17/00234 , A61B17/320758 , A61B34/20 , A61B34/30 , A61B2017/00345 , A61B2034/303 , A61B2034/732 , A61B2090/3762 , A61B2090/378 , A61M2025/09183
摘要： The present invention relates to a medical robot system capable of effectively removing a calcified thrombus in a blood vessel. The present invention proposes a new guide-wired helical microrobot for mechanical thrombectomy applied to a calcified thrombus. Also, the present invention proposes an electromagnetic navigation system (ENS) which uses a high frequency operation that is based on a resonant effect in order to enhance the boring force of a microrobot. The microrobot system of the present invention can precisely tunnel through a blood vessel blockage site by means of the electromagnetic navigation system without damaging blood vessel walls. The microrobot system of the present invention has a wide range of applications including not only for thrombosis, but also thromboangiitis obliterans caused by vasoocclusion, cerebral infarction, strokes, angina or myocardial infarction, peripheral artery occlusive disease, or atherosclerosis, etc.
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公开(公告)号：US20230136448A1
公开(公告)日：2023-05-04
申请号：US17517621
申请日：2021-11-02
申请人： Industry Foundation of Chonnam National University , Korea Institute of Medical Mcrorobotics , Johns Hopkins University
发明人： Eun Pyo Choi , Jong Oh Park , Chang Sei Kim , You Hee Choi , Byung Jeon Kang , Ho Yong Kim , Hyeong Woo Song , Dae Won Jung , Han Sol Lee , Deok Ho Kim , Min Jae Do
摘要： Disclosed herein are a microbubble-extracellular vesicle complex, a production method therefor, and a system for driving the same. In one aspect, preferred microbubble-extracellular vesicle complexes may comprise an ultrasound contrast agent-based microbubble, an extracellular cell derived from a natural killer cell (NK cell), a human glial cell, or a human mesenchymal stem cell, and a coupling medium and can be derive in a 3D mode using ultrasonic waves and deliver a drug loaded in the extracellular vesicle to a target site.
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