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公开(公告)号：US20220016042A1
公开(公告)日：2022-01-20
申请号：US17411591
申请日：2021-08-25
发明人： Neal VAN HOEVEN , Traci MIKASA , Christopher B. FOX , Anwar AHNIYAZ , Mark T. ORR , Amit KHANDHAR
摘要： Provided herein are nanoalum particles comprising an aluminum salt and a sizing agent, wherein the size of the particle ranges from about 1 nm to 450 nm. Such a nanoalum particles are stable and are amenable to a terminal sterilization step prior to vialing. Compositions comprising the nanoalum particles, and the making and using of the nanoalum particles are also provided.
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公开(公告)号：US20200230056A1
公开(公告)日：2020-07-23
申请号：US16622908
申请日：2018-06-15
摘要： Provided herein are nanostructured lipid carrier compositions, and methods of making and using thereof. The compositions comprise a nanostructured lipid carrier (NLC), where the NLC comprises an oil core comprising a mixture of a liquid phase lipid and a solid phase lipid, a cationic lipid, a sorbitan ester, and a hydrophilic surfactant, and optionally a bioactive agent. The bioactive agent can be associated with the NLC. The compositions are capable of delivery of a biomolecule to a cell for the generation of an immune response, for example, for vaccine, therapeutic, or diagnostic uses. Compositions and methods related to making the compositions and using the compositions for stimulating an immune response are also provided.
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公开(公告)号：US20160324783A1
公开(公告)日：2016-11-10
申请号：US15108773
申请日：2014-12-29
CPC分类号： A61K9/19 , A61K39/00 , A61K39/04 , A61K39/39 , A61K47/10 , A61K47/22 , A61K47/26 , A61K2039/552 , A61K2039/55511 , A61K2039/55572
摘要： The invention provides for thermostable lyophilized formulations, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response, and methods of use thereof. The lyophilized formulations generally comprise an antigen and/or an adjuvant, a metabolizable oil, and a cake-forming excipient.
摘要翻译： 本发明提供了耐热冻干制剂，包括用于诱导或增强免疫应答的疫苗和药物组合物及其使用方法。 冻干制剂通常包含抗原和/或佐剂，可代谢的油和成饼赋形剂。
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公开(公告)号：US20220054416A1
公开(公告)日：2022-02-24
申请号：US17470874
申请日：2021-09-09
摘要： Provided herein are nanostructured lipid carrier compositions, and methods of making and using thereof. The compositions comprise a nanostructured lipid carrier (NLC), where the NLC comprises an oil core comprising a mixture of a liquid phase lipid and a solid phase lipid, a cationic lipid, a sorbitan ester, and a hydrophilic surfactant, and optionally a bioactive agent. The bioactive agent can be associated with the NLC. The compositions are capable of delivery of a biomolecule to a cell for the generation of an immune response, for example, for vaccine, therapeutic, or diagnostic uses. Compositions and methods related to making the compositions and using the compositions for stimulating an immune response are also provided.
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公开(公告)号：US20200276299A1
公开(公告)日：2020-09-03
申请号：US16645456
申请日：2018-09-07
发明人： Christopher B. FOX , Susan S. LIN
IPC分类号： A61K39/21 , A61K47/24 , A61K39/04 , A61K39/015
摘要： Provided herein are liposomal formulations containing saponin and optionally, a lipopolysaccharide. Also provided IC herein are pharmaceutical compositions and vaccine compositions comprising the liposomal formulations and an antigen. The pharmaceutical compositions and vaccine compositions are capable of eliciting or enhancing of an immune response, for example, for vaccine or therapeutic uses. Compositions and methods related to making the liposomal formulations and using the liposomal formulations for eliciting or enhancing an immune response are also provided.
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