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公开(公告)号：US20180296618A1
公开(公告)日：2018-10-18
申请号：US15882477
申请日：2018-01-29
发明人： Lingyun Xiao , Renhuai Cong , Minghua Hu , Yuanyuan Wang , Fangli Ma , Chung Wah Ma
IPC分类号： A61K36/258 , A61K36/9062 , A61K36/704 , A61K36/71
CPC分类号： A61K36/258 , A61K36/704 , A61K36/71 , A61K36/9062 , A61K2236/331 , A61K2300/00
摘要： The present invention relates to the technical field of health-care product, and in particular relates to a traditional Chinese medicine composition having a function of regulating emotions, a process for preparing the same, and a product thereof. It was found that the composition of the present invention had effects of nourishing liver and kidney, regulating Yin and Yang, tonifying Qi and nourishing blood, regulating emotions, and protecting the function of autonomic nerve, and could improve pressure-induced anxiety and depression, inattention, poor spirit, dispirited, learning and memory capacity decline, etc. The invention has the advantages of specificity and remarkable effect, and it uses all natural medicinal and edible plants as raw materials, the combination of which is simple, safe and stable, and is suitable for long-term use.
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公开(公告)号：US11291697B2
公开(公告)日：2022-04-05
申请号：US16520359
申请日：2019-07-24
发明人： Yuanyuan Wang , Wei Chen , Gang Wang , Xiaofeng Zhu , Fangli Ma , Junyong Xiao , Hao Zhang , Jianxin Zhao
IPC分类号： A61K35/745 , A23L33/135 , A61P1/00 , A61K35/747
摘要： The present disclosure relates to the field of microbial technology, and discloses a probiotic composition and use thereof. The probiotic composition in the present disclosure is consisted of Bifidobacterium adolescentis CCFM8630, Lactobacillus reuteri CCFM8631 and Lactobacillus rhamnosus CCFM1044, whose effect of alleviating metabolic syndrome is significantly better than that of CCFM8630 or CCFM8631 alone or combination of the two, especially in aspects of lowering epididymal fat content, lowering fasting blood glucose level, lowering the area under sugar tolerance curve and lowering contents of serum low density lipoprotein and total cholesterol, improving liver antioxidant capacity and lowering serum IL-1β content, etc. The extent of decrease or increase is increased by 9.62% to 769.62% compared with formulations of a single probiotic or a combination of two probiotics. The combination of three probiotics achieves a significant synergistic effect.
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公开(公告)号：US11026988B2
公开(公告)日：2021-06-08
申请号：US16058484
申请日：2018-08-08
发明人： Fangli Ma , Yuanyuan Wang , Minghua Hu , Renhuai Cong , Lingyun Xiao , Chung Wah Ma
IPC分类号： A61K36/54 , A61K36/00 , A61K36/815 , A23L33/105 , A23L33/115 , A23L33/12 , A23L33/125 , A61P35/00 , A61K31/715 , A61K36/61 , A61K36/8969
摘要： The present disclosure relates to the field of drugs and health foods. Disclosed is a traditional Chinese medicine composition comprising Lycii fructus polysaccharide, Polygonati rhizoma polysaccharide, Caryophylli flos oil and Cinnamomi cortex oil. Experiments show that the traditional Chinese medicine composition has a scientific formulation, synergistic functions, without toxic and side effects, and not only has nutritional value but also inhibits the growth of tumor. Comparing with individual components, the composition significantly increases the percentages of CD4+ and CD8+ cells in lymphocytes of the tumor stroma, increases body immune function, recovers normal immune surveillance function, decreases the expression rate of VEGF and TGF-β 1 positive cells in tumor tissue, assists in treating tumor, increases antitumor effects of chemotherapy drugs, improves immune status of body, has the function of restoring normal immune surveillance, preventing and assisting in treating tumor.
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公开(公告)号：US10967016B2
公开(公告)日：2021-04-06
申请号：US16058937
申请日：2018-08-08
发明人： Yuanyuan Wang , Fangli Ma , Renhuai Cong , Minghua Hu , Chung Wah Ma
IPC分类号： A61K36/00 , A61K36/074 , A23L33/21 , A23L33/105 , A23L33/10 , A61P35/00 , A61K36/232 , A61K36/61 , A61K36/746 , A61K36/8969
摘要： The present disclosure relates to the field of drugs and health foods. Disclosed is a traditional Chinese medicine composition comprising GANODERMA polysaccharide, MORINDAE OFFICINALIS RADIX polysaccharide, POLYGONATI RHIZOMA polysaccharide, ANGELICAE SINENSIS RADIX oil and MYRISTICAE SEMEN oil. Experiments show that the traditional Chinese medicine composition has a scientific formulation, synergistic functions, without toxic and side effects, and not only has nutritional value but also inhibits the growth of tumor. Comparing with individual components, the composition significantly increases the percentages of CD4+ and CD8+ cells in lymphocytes of the tumor stroma, enhances body immune function, restores normal immune surveillance function, decreases VEGF and TGF-β1 positive cells in tumor tissue, assists in treating tumor, increases antitumor effects of chemotherapy drugs, improves immune status of body, has the function of restoring normal immune surveillance, preventing and assisting in treating tumor.
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公开(公告)号：US11446342B2
公开(公告)日：2022-09-20
申请号：US16520366
申请日：2019-07-24
发明人： Fangli Ma , Wei Chen , Gang Wang , Xiaofeng Zhu , Yuanyuan Wang , Junyong Xiao , Hao Zhang , Jianxin Zhao
IPC分类号： A61K9/19 , A61K35/747 , A61K35/745
摘要： The present disclosure relates to the field of microbial technology, and discloses a composite probiotics and the use thereof. The composite probiotics in the present disclosure is consisted of Bifidobacterium adolescentis CCFM8630, Lactobacillus reuteri CCFM8631, Lactobacillus rhamnosus CCFM1044 and Lactobacillus casei CCFM711, whose effect of alleviating metabolic syndrome is significantly better than that of CCFM8630 or CCFM8631 alone or combination of the two, especially in aspects of lowering contents of serum low density lipoprotein, total cholesterol, and liver triglyceride and contents of serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and IFN-γ, and increasing contents of liver glutathione and superoxide dismutase, etc. The extent of decrease or increase is increased by 7.91% to 837.31% compared with the formulations of CCFM8630 or CCFM8631 alone or combination of the two probiotics. The combination of the four probiotics can achieve a significant synergistic effect.
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公开(公告)号：US10967017B2
公开(公告)日：2021-04-06
申请号：US16100034
申请日：2018-08-09
发明人： Minghua Hu , Fangli Ma , Yuanyuan Wang , Chung Wah Ma , Renhuai Cong , Lingyun Xiao
IPC分类号： A61K36/00 , A61K36/074 , A61K36/07 , A61P37/02 , A61P35/00 , A61K36/232 , A61K36/54
摘要： The present disclosure relates to the field of drugs and health foods. Disclosed is a traditional Chinese medicine composition comprising GANODERMA polysaccharide, GRIFOLA FRONDOSA polysaccharide, ANGELICAE SINENSIS RADIX oil and CINNAMOMI CORTEX oil. Experiments show that the traditional Chinese medicine composition has a scientific formulation, synergistic functions, without toxic and side effects, and not only has nutritional value but also inhibits the growth of tumor. Comparing with individual components, the composition significantly increases the percentages of CD4+ and CD8+ cells in lymphocytes of the tumor stroma, increases body immune function, recovers normal immune surveillance function, decreases the expression rate of VEGF and TGF-β 1 positive cells in tumor tissue, assists in treating tumor, increases antitumor effects of chemotherapy drugs, improves immune status of body, has the function of restoring normal immune surveillance, preventing and assisting in treating tumor.
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公开(公告)号：US10960039B2
公开(公告)日：2021-03-30
申请号：US15870809
申请日：2018-01-12
发明人： Lingyun Xiao , Renhuai Cong , Yuanyuan Wang , Fangli Ma , Chung Wah Ma
IPC分类号： A61K36/284 , A61K36/236 , A61P5/14
摘要： The present disclosure relates to the technical field of health care products and foodstuffs, in particular to a composition, a preparation method, and the use thereof in preparation of products for relieving thyroid nodules. The composition provided by the invention uses AtractylodisMacrocephalaeRhizoma and ChuanxiongRhizoma as raw materials, which show synergistic effect through rational combination. Experiments show that the composition provided by the invention can improve thyroid epithelial cell proliferation and reduce the thyroid index of thyroid nodules, and has the advantages of relieving thyroid nodules and protecting thyroid function. The invention has the advantages of simple combination, high safety, simple and easy handling and definite cure effect.
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公开(公告)号：US10744173B2
公开(公告)日：2020-08-18
申请号：US15882477
申请日：2018-01-29
发明人： Lingyun Xiao , Renhuai Cong , Minghua Hu , Yuanyuan Wang , Fangli Ma , Chung Wah Ma
IPC分类号： A61K36/258 , A61K36/9062 , A61K36/71 , A61K36/704
摘要： The present invention relates to the technical field of health-care product, and in particular relates to a traditional Chinese medicine composition having a function of regulating emotions, a process for preparing the same, and a product thereof. It was found that the composition of the present invention had effects of nourishing liver and kidney, regulating Yin and Yang, tonifying Qi and nourishing blood, regulating emotions, and protecting the function of autonomic nerve, and could improve pressure-induced anxiety and depression, inattention, poor spirit, dispirited, learning and memory capacity decline, etc. The invention has the advantages of specificity and remarkable effect, and it uses all natural medicinal and edible plants as raw materials, the combination of which is simple, safe and stable, and is suitable for long-term use.
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