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公开(公告)号：USRE46621E1
公开(公告)日：2017-12-05
申请号：US15051529
申请日：2016-02-23
发明人： Pingda Ren , Michael Martin , Paul Isbester , Benjamin S. Lane , Jason Kropp
IPC分类号： C07D473/34 , A61P35/00 , A61K31/52
CPC分类号： C07D473/34
摘要： Polymorphs of chemical compounds that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including P13 kinase activity, are described herein. Also provided herein are processes for preparing compounds, polymorphs thereof, and pharmaceutical compositions thereof.
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公开(公告)号：US20170137407A1
公开(公告)日：2017-05-18
申请号：US15333803
申请日：2016-10-25
发明人： Alfredo C. Castro , Catherine A. Evans , Somarajannair Janardanannair , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
IPC分类号： C07D401/14 , C12N9/12
CPC分类号： C07D401/14 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/14 , C07D411/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04 , C12N9/1205 , C12Y207/01137 , Y02A50/414
摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including P13 kinase activity, are described herein.
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公开(公告)号：US09718815B2
公开(公告)日：2017-08-01
申请号：US14592628
申请日：2015-01-08
发明人： Alfredo C. Castro , Catherine A. Evans , Somarajannair Janardanannair , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
IPC分类号： C07D471/04 , C07D487/04 , C07D473/34 , C07D495/04 , C07D513/04
CPC分类号： C07D471/04 , C07D473/34 , C07D487/04 , C07D495/04 , C07D513/04
摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
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公开(公告)号：US09605003B2
公开(公告)日：2017-03-28
申请号：US14710336
申请日：2015-05-12
发明人： Alfredo C. Castro , Catherine A. Evans , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
IPC分类号： A01N43/90 , A61K31/519 , C07D513/04 , C07D519/00
CPC分类号： C07D513/04 , A61K31/519 , C07D519/00
摘要： Substituted bicyclic heterocyclic compounds such as isoquinolinone compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
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公开(公告)号：US08940742B2
公开(公告)日：2015-01-27
申请号：US13841265
申请日：2013-03-15
发明人： Alfredo C. Castro , Katrina Chan , Catherine A. Evans , Somarajannair Janardanannair , Andre Lescarbeau , Liansheng Li , Tao Liu , Yi Liu , Pingda Ren , Daniel A. Snyder , Martin R. Tremblay
IPC分类号： A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495 , C07D401/12 , C07D487/04 , C07D405/12 , C07D491/056 , C07D401/14 , C07D217/24 , C07D413/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07D403/12 , C07D217/26 , C07D401/04 , C07D417/14 , C07D491/048 , C07D513/04 , C07D519/00
CPC分类号： C07D519/00 , A61K31/519 , C07D217/24 , C07D217/26 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D513/04 , Y02A50/414
摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
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6.发明授权公开(公告)号：US11312718B2
公开(公告)日：2022-04-26
申请号：US16734135
申请日：2020-01-03
发明人： Pingda Ren , Michael Martin , Paul Isbester , Benjamin S. Lane , Jason Kropp
摘要： Polymorphs of chemical compounds that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including P13 kinase activity, are described herein. Also provided herein are processes for preparing compounds, polymorphs thereof, and pharmaceutical compositions thereof.
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公开(公告)号：US09840505B2
公开(公告)日：2017-12-12
申请号：US15016117
申请日：2016-02-04
发明人： Pingda Ren , Michael Martin , Paul Isbester , Benjamin S. Lane , Jason Kropp
IPC分类号： C07D473/34 , A61K31/52 , A61P35/00
CPC分类号： C07D473/34
摘要： Polymorphs of chemical compounds that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. Also provided herein are processes for preparing compounds, polymorphs thereof, and pharmaceutical compositions thereof.
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公开(公告)号：US09546180B2
公开(公告)日：2017-01-17
申请号：US14297526
申请日：2014-06-05
发明人： Alfredo C. Castro , Catherine A. Evans , Somarajannair Janardanannair , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
IPC分类号： C07D495/04 , C07D401/14 , C07D413/14 , C07D401/12 , C07D411/14 , C07D417/14 , C07D487/04 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D403/12 , C07D405/14 , C07D471/04 , C07D403/14 , C07D513/04
CPC分类号： C07D401/14 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/14 , C07D411/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04 , C12N9/1205 , C12Y207/01137 , Y02A50/414
摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including P13 kinase activity, are described herein.
摘要翻译： 本文描述了调节激酶活性（包括PI3激酶活性）的化合物和药物组合物，以及化合物，药物组合物和治疗与激酶活性（包括P13激酶活性）相关的疾病和病症的方法。
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公开(公告)号：US09255108B2
公开(公告)日：2016-02-09
申请号：US14573961
申请日：2014-12-17
发明人： Alfredo C. Castro , Katrina Chan , Catherine A. Evans , Somarajannair Janardanannair , Andre Lescarbeau , Liansheng Li , Tao Liu , Yi Liu , Pingda Ren , Daniel A. Snyder , Martin R. Tremblay
IPC分类号： A61K31/519 , C07D487/04 , C07D401/12 , C07D405/12 , C07D491/056 , C07D401/14 , C07D217/24 , C07D413/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07D403/12 , C07D217/26 , C07D401/04 , C07D417/14 , C07D491/048 , C07D513/04 , C07D519/00
CPC分类号： C07D519/00 , A61K31/519 , C07D217/24 , C07D217/26 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D513/04 , Y02A50/414
摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
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公开(公告)号：US20180273535A1
公开(公告)日：2018-09-27
申请号：US15799612
申请日：2017-10-31
发明人： Pingda Ren , Michael Martin , Paul Isbester , Benjamin S. Lane , Jason Kropp
IPC分类号： C07D473/34
摘要： Polymorphs of chemical compounds that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including Pl3 kinase activity, are described herein. Also provided herein are processes for preparing compounds, polymorphs thereof, and pharmaceutical compositions thereof.
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