专利检索 ap:("INSERM (INSTITUT NATIONAL DE LA SANTÉ ET LA RECHERCHE MÉDICALE" OR "CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE" OR "UNIVERSITE DE NICE SOPHIA ANTIPOLIS-GRAND CHÂTEAU") AND inv:"Jacob HECKSHER-SØRENSEN" 第 1 页

1.

发明申请
ALPHA-CELL RE-GENERATION COMBINED WITH CONVERSION TO BETA CELLS 审中-公开

公开(公告)号：US20170340591A1

公开(公告)日：2017-11-30

申请号：US15538031

申请日：2015-12-23

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET LA RECHERCHE MÉDICALE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE NICE SOPHIA ANTIPOLIS-GRAND CHÂTEAU

发明人： Jacob HECKSHER-SØRENSEN , Patrick COLLOMBAT

IPC分类号： A61K31/197 , C12N5/071 , A61K35/39 , A61K45/06 , A61K39/00 , A61K31/00

CPC分类号： A61K31/197 , A61K31/00 , A61K35/39 , A61K39/00 , A61K45/06 , A61K2039/505 , C07K16/26 , C07K2317/76 , C12N5/0676 , C12N2501/335 , C12N2501/845 , C12N2506/22 , A61K2300/00

摘要： The present invention relates to methods of generating a population of beta cells from a population of alpha cells, by contacting said population of alpha cells with GABA or a GABA receptor agonist, in combination with a monoclonal glucagon neutralizing antibody or other alpha cell mass regulating compounds, for an improved diabetes therapy.