公开(公告)号：US10561856B2

公开(公告)日：2020-02-18

申请号：US15025623

申请日：2014-11-25

申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE DE LILLE 2 DROIT ET SANTE ,  CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU)

发明人： Serge Mordon ,  Nacim Betrouni ,  Laurent Mortier

IPC分类号： A61N5/06

摘要： The system comprises: —a bundle of light fibers (11) connected to a light-emitting source (8), and both transmitting light inside the light fiber and emitting light toward a treatment volume (V), —a temperature-modifying system attached to the bundle of light fibers (11) to modify temperature in the treatment volume (V).

公开(公告)号：US11135443B2

公开(公告)日：2021-10-05

申请号：US16086228

申请日：2017-03-24

申请人： INSERM (Institut National de la Sante et de la Recherche Medicale) ,  Universite de Lille ,  Centre Hospitalier Regional et Universitaire de Lille (CHRU)

发明人： Maximilien Vermandel ,  Clement Dupont ,  Nicolas Reyns ,  Pascal Deleporte ,  Serge Mordon ,  Nacim Betrouni

IPC分类号： A61N5/06 ,  A61N5/067

摘要： System (1) for treatment by photodynamic therapy comprising an illuminating member (6) which comprises: —a core (35) carrying a light emitting surface (37), and —a hollow sheath (10) adapted to receive the core (35) with the light emitting surface (37) arranged within a balloon (11), the balloon (11) comprising a wall (12) which has an inner surface delimiting an internal space, and an outer surface, the wall (12) being flexible, wherein the internal space of the balloon (11) has a variable capacity, the wall (12) of the balloon (11) being elastically extendible and the balloon (11) presenting a plurality of inflated states in each of which the internal space is filled with a volume of light diffusing solution, and wherein the system further comprises a support provided with a transfer function relating the volume of light diffusing solution of each inflated state with at least one of a corresponding distribution of light power at the outer surface of the wall (12) of the balloon (11) and a corresponding time of illumination for providing a determined dose of light energy.

公开(公告)号：US10401567B2

公开(公告)日：2019-09-03

申请号：US16074937

申请日：2017-02-03

申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE DE LILLE 2 DROIT ET SANTE ,  CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU)

发明人： Serge Mordon ,  Pascal Delepôrte ,  Nacim Betrouni

IPC分类号： G02B6/02 ,  G02B6/14 ,  H04B10/2581

摘要： An optical fiber mode scrambler adapted to give a determined bending to an optical fiber inserted in the mode scrambler, the mode scrambler having a general extension direction X, the mode scrambler having a morphology adapted to give the optical fiber a direction along X at the entry of the scrambler, and then to bend the fiber to bring the fiber substantially in the X, Y plan in the −X and Y directions, before bringing the fiber in a rotation around the X axis substantially in the Y, Z plan in the anti clockwise direction for one full rotation, and then bending the fiber to bring the fiber substantially in the X, Y plan in the −X and −Y directions, and then bending the fiber to give the optical fiber a direction along X at the exit of the scrambler.