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1.发明授权公开(公告)号：US11975072B2
公开(公告)日：2024-05-07
申请号：US16632649
申请日：2018-07-20
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITE DE LILLE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE LORRAINE , INSTITUT PASTEUR DE LILLE , CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE
发明人： Henri Azais , Pierre Collinet , Nadira Delhem-Fellahi , Olivier Morales , Serge Mordon , Céline Frochot , Régis Vanderesse , Aurélie Stallivieri
CPC分类号： A61K41/0071 , A61K47/546 , A61K49/0052 , A61P35/00
摘要： The invention relates to a compound of formula (I) and to the pharmaceutically acceptable salts thereof. The invention also relates to the use of said compound of formula (I) in the treatment of cancer, particularly by photodynamic therapy.
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公开(公告)号：US20240045200A1
公开(公告)日：2024-02-08
申请号：US18267280
申请日：2021-12-13
申请人： UNIVERSITE DE LILLE , CENTRALE LILLE INSTITUT , UNIVERSITE POLYTECHNIQUE HAUTS-DE-FRANCE , Centre National de la Recherche Scientifique , Valeo Systèmes d'Essuyage
CPC分类号： G02B27/0006 , B08B7/028 , B60S1/56 , G01S2007/4977
摘要： The invention relates to a device (5) comprising: —an optical surface (10); —a cleaning unit (15) for cleaning the optical surface, comprising at least one wave transducer (70) acoustically coupled to the optical surface, the wave transducer having a piezoelectric layer (80) and electrodes (85) of opposite polarity in contact with the piezoelectric layer, and being configured to generate at least one surface ultrasonic wave (WS) or a Lamb wave (WL) propagating in the optical surface; —the optical surface having at least one region of optical interest (100) not superposed on the wave transducer, the device comprising an apparatus (20) configured to sense and/or to emit radiation (R) through the region of optical interest (100).
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公开(公告)号：US20230285476A1
公开(公告)日：2023-09-14
申请号：US18016622
申请日：2021-07-19
IPC分类号： A61K35/747 , A61P1/00 , A61P31/04 , C12N1/20
CPC分类号： A61K35/747 , A61P1/00 , A61P31/04 , C12N1/205 , C12R2001/225
摘要： The present invention relates to a mixture of microorganisms comprising a Lactobacillus reuteri strain and a Lactobacillus salivarius strain, and to the use thereof for preparing an animal additive or feed product and for preventing or treating necrotic enteritis.
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4.发明公开公开(公告)号：US20230207300A1
公开(公告)日：2023-06-29
申请号：US17926730
申请日：2021-05-20
申请人： UNIVERSITE DE LILLE , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU)
发明人： Isabelle SALZET , Julien FRANCK , Michel SALZET , Flore HERVE
IPC分类号： H01J49/04 , H01J49/26 , G01N33/497 , H01J49/10
CPC分类号： H01J49/049 , G01N33/497 , H01J49/26 , H01J49/105
摘要： A system and method for analyzing volatile organic compounds (VOCs) adsorbed on an adsorbent membrane, by low-temperature plasma and mass spectrometry (LTP-MS). The system includes a receptacle for receiving the adsorbent membrane, a low-temperature plasma ionizer configured to emit a plasma stream in a plasma emission direction, thereby ionizing the VOCs adsorbed by the membrane and forming a VOC-laden ionized gas, and a mass spectrometer for analyzing the ionized VOCs.
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公开(公告)号：US20230135837A1
公开(公告)日：2023-05-04
申请号：US16650070
申请日：2018-09-27
申请人： CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU) , UNIVERSITE DE LILLE , UNIVERSITE DU LITTORAL COTE D'OPALE , INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , TAIPEI MEDICAL UNIVERSITY
摘要： The present invention relates on a process for preparing platelet lysate fraction, said process comprising the steps of: 1) providing a platelet lysate, 2) collecting from said platelet lysate a fraction wherein the components exhibit a maximum molecular weight of 100 kDa, on a specific platelet lysate fraction and its use as a drug.
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6.发明申请公开(公告)号：US20220378914A1
公开(公告)日：2022-12-01
申请号：US16632649
申请日：2018-07-20
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITE DE LILLE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE LORRAINE , INSTITUT PASTEUR DE LILLE , CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE
发明人： Henri AZAIS , Pierre COLLINET , Nadira DELHEM-FELLAHI , Olivier MORALES , Serge MORDON , Céline FROCHOT , Régis VANDERESSE , Aurélie STALLIVIERI
摘要： The invention relates to a compound of formula (I) and to the pharmaceutically acceptable salts thereof. The invention also relates to the use of said compound of formula (I) in the treatment of cancer, particularly by photodynamic therapy.
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公开(公告)号：US11496049B2
公开(公告)日：2022-11-08
申请号：US16789589
申请日：2020-02-13
申请人： Universite de Lille , Centre National De La Recherche Scientifique , ISEN Yncrea Hauts-de-France , STMicroelectronics SA
发明人： Angel de Dios Gonzalez Santos , Andreas Kaiser , Antoine Frappe , Philippe Cathelin , Benoit Larras
摘要： A continuous time digital signal processing (CT DSP) token includes a first signal indicating a change has occurred and a second signal indicating a direction of the change. An amplitude generation circuit operates to generate an amplitude value x in response to the token. A power estimation circuit processes the amplitude value x to generate a digital power signal in accordance with the formula: x2±2x+1.
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公开(公告)号：US20220339669A1
公开(公告)日：2022-10-27
申请号：US17763016
申请日：2020-09-24
申请人： UNIVERSITE DE LILLE , CENTRALE LILLE INSTITUT , UNIVERSITE POLYTECHNIQUE HAUTS-DE-FRANCE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , YNCREA HAUTS DE FRANCE , VALEO SYSTEMES D'ESSUYAGE
摘要： Electroacoustic device (5) comprising: an ultrasonic wave transducer (15) comprising a piezoelectric substrate (10) and first (30) and second (35) electrodes in contact with the piezoelectric substrate, and a carrier (10), the transducer being attached to the carrier and acoustically coupled to the carrier, and the first and second electrodes being sandwiched, at least partly, between the piezoelectric substrate and the carrier, the device being configured to generate an ultrasonic surface wave (W) propagating through the carrier at a distance from the transducer when an electric current passes through the first and second electrodes.
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9.发明授权公开(公告)号：US11226343B2
公开(公告)日：2022-01-18
申请号：US16092027
申请日：2017-04-07
申请人： LUNGINNOV , INSERM (INSTITUTE NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITE DE LILLE , INSTITUT PASTEUR DE LILLE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS -
摘要： The present invention relates to methods and kits for diagnosing a postoperative pulmonary infection in a patient who underwent surgery. More particularly, the present invention relates to a method for diagnosing a postoperative pulmonary infection in a patient who underwent surgery, comprising a step consisting of measuring the concentration of endocan in a blood sample obtained from said patient, at a time point comprised between 3 h and 30 h after surgery.
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公开(公告)号：US11135443B2
公开(公告)日：2021-10-05
申请号：US16086228
申请日：2017-03-24
申请人： INSERM (Institut National de la Sante et de la Recherche Medicale) , Universite de Lille , Centre Hospitalier Regional et Universitaire de Lille (CHRU)
发明人： Maximilien Vermandel , Clement Dupont , Nicolas Reyns , Pascal Deleporte , Serge Mordon , Nacim Betrouni
摘要： System (1) for treatment by photodynamic therapy comprising an illuminating member (6) which comprises: —a core (35) carrying a light emitting surface (37), and —a hollow sheath (10) adapted to receive the core (35) with the light emitting surface (37) arranged within a balloon (11), the balloon (11) comprising a wall (12) which has an inner surface delimiting an internal space, and an outer surface, the wall (12) being flexible, wherein the internal space of the balloon (11) has a variable capacity, the wall (12) of the balloon (11) being elastically extendible and the balloon (11) presenting a plurality of inflated states in each of which the internal space is filled with a volume of light diffusing solution, and wherein the system further comprises a support provided with a transfer function relating the volume of light diffusing solution of each inflated state with at least one of a corresponding distribution of light power at the outer surface of the wall (12) of the balloon (11) and a corresponding time of illumination for providing a determined dose of light energy.
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