公开(公告)号：US20230241171A1

公开(公告)日：2023-08-03

申请号：US18004801

申请日：2021-07-09

Applicant: INSTITUT PASTEUR ,  MCMASTER UNIVERSITY

Inventor： Lida KATSIMPARDI ,  Pierre-Marie LLEDO ,  Bianca WOLLENHAUPT DE AGUIAR ,  Taiane DE AZEVEDO CARDOSO ,  Flavio KAPCZINSKI ,  Bianca PFAFFENSELLER

IPC: A61K38/18 ,  G01N33/68 ,  A61P25/24 ,  C07K16/22

CPC classification number: A61K38/1841 ,  G01N33/6896 ,  A61P25/24 ,  C07K16/22 ,  G01N2800/304

Abstract: Provided are methods for the detection of GDF11 in a subject having or suspected of having a mood and/or anxiety disorder, comprising providing a sample from a subject having or suspected of having a mood and/or anxiety disorder; contacting the sample with a GDF11-binding molecule; and detecting bound GDF11. Also provided are methods of diagnosing or characterizing a mood and/or anxiety disorder in a subject, comprising providing a sample from a subject; contacting the sample with a GDF11-binding molecule; detecting bound GDF11; and comparing the levels of detected bound GDF11 to healthy reference levels. Also provided are methods of treating or preventing a mood and/or anxiety disorder and/or accelerated aging in a subject in need thereof, comprising administering to the subject an agent or composition which increases the levels of GDF11 polypeptide in the subject.