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1.发明申请公开(公告)号：US20230094291A1
公开(公告)日：2023-03-30
申请号：US17811235
申请日：2022-07-07
Inventor： Jie Tian , Yanjun Liu , Hui Hui , Lin Yin , Xin Feng
IPC: A61B5/0515 , G01R33/54
Abstract: The present disclosure belongs to a field of biomedical imaging technology, and in particularly to a non-uniform excitation field-based method and system for performing a magnetic nanoparticle imaging. The present disclosure includes: separating the non-uniform excitation field into independent space and current time functions by a spatialtemporal separation method; calculating a normalized signal peak through the current time function; constructing a reconstruction mathematical model based on the normalized signal peak and an imaging subunit volume; and quantitatively reconstructing a spatial distribution of a nanoparticle by combining the normalized signal peak, a non-uniform spatial function of the excitation field and the reconstruction mathematical model, so as to achieve the magnetic nanoparticle imaging of a to-be-reconstructed object.
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2.发明授权公开(公告)号：US12136145B2
公开(公告)日：2024-11-05
申请号：US17811738
申请日：2022-07-11
IPC: G06T11/00 , A61B5/00 , A61B5/0515
Abstract: The present disclosure includes: transforming a time-domain voltage signal collected by an MPI system device to a frequency domain; calculating a square root of a square sum of a real part and an imaginary part at each frequency point of a frequency domain signal; arranging acquired amplitudes in a descending order, and acquiring a screening threshold by an amplitude ratio method; screening an amplitude through the screening threshold and constructing frequency domain signal data; acquiring a row vector of a system matrix corresponding to each frequency point of the data, so as to construct an update system matrix; and solving, based on the frequency domain signal array and the update system matrix, an inverse problem in a form of a least square based on an L2 constraint to obtain a three-dimensional magnetic particle concentration distribution result, so as to achieve a fast reconstruction of the MPI system.
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3.发明授权公开(公告)号：US11771336B2
公开(公告)日：2023-10-03
申请号：US17811235
申请日：2022-07-07
Inventor： Jie Tian , Yanjun Liu , Hui Hui , Lin Yin , Xin Feng
IPC: A61B5/0515 , G01R33/54
CPC classification number: A61B5/0515 , G01R33/54
Abstract: The present disclosure belongs to a field of biomedical imaging technology, and in particularly to a non-uniform excitation field-based method and system for performing a magnetic nanoparticle imaging. The present disclosure includes: separating the non-uniform excitation field into independent space and current time functions by a spatialtemporal separation method; calculating a normalized signal peak through the current time function; constructing a reconstruction mathematical model based on the normalized signal peak and an imaging subunit volume; and quantitatively reconstructing a spatial distribution of a nanoparticle by combining the normalized signal peak, a non-uniform spatial function of the excitation field and the reconstruction mathematical model, so as to achieve the magnetic nanoparticle imaging of a to-be-reconstructed object.
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4.发明申请公开(公告)号：US20230027988A1
公开(公告)日：2023-01-26
申请号：US17811738
申请日：2022-07-11
IPC: G06T11/00 , A61B5/0515 , A61B5/00
Abstract: The present disclosure includes: transforming a time-domain voltage signal collected by an MPI system device to a frequency domain; calculating a square root of a square sum of a real part and an imaginary part at each frequency point of a frequency domain signal; arranging acquired amplitudes in a descending order, and acquiring a screening threshold by an amplitude ratio method; screening an amplitude through the screening threshold and constructing frequency domain signal data; acquiring a row vector of a system matrix corresponding to each frequency point of the data, so as to construct an update system matrix; and solving, based on the frequency domain signal array and the update system matrix, an inverse problem in a form of a least square based on an L2 constraint to obtain a three-dimensional magnetic particle concentration distribution result, so as to achieve a fast reconstruction of the MPI system.
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