公开(公告)号：US11771336B2

公开(公告)日：2023-10-03

申请号：US17811235

申请日：2022-07-07

Applicant: INSTITUTE OF AUTOMATION, CHINESE ACADEMY OF SCIENCES

Inventor： Jie Tian ,  Yanjun Liu ,  Hui Hui ,  Lin Yin ,  Xin Feng

IPC: A61B5/0515 ,  G01R33/54

CPC classification number: A61B5/0515 ,  G01R33/54

Abstract: The present disclosure belongs to a field of biomedical imaging technology, and in particularly to a non-uniform excitation field-based method and system for performing a magnetic nanoparticle imaging. The present disclosure includes: separating the non-uniform excitation field into independent space and current time functions by a spatialtemporal separation method; calculating a normalized signal peak through the current time function; constructing a reconstruction mathematical model based on the normalized signal peak and an imaging subunit volume; and quantitatively reconstructing a spatial distribution of a nanoparticle by combining the normalized signal peak, a non-uniform spatial function of the excitation field and the reconstruction mathematical model, so as to achieve the magnetic nanoparticle imaging of a to-be-reconstructed object.

公开(公告)号：US20230094291A1

公开(公告)日：2023-03-30

申请号：US17811235

申请日：2022-07-07

Applicant: INSTITUTE OF AUTOMATION, CHINESE ACADEMY OF SCIENCES

Inventor： Jie Tian ,  Yanjun Liu ,  Hui Hui ,  Lin Yin ,  Xin Feng

IPC: A61B5/0515 ,  G01R33/54

Abstract: The present disclosure belongs to a field of biomedical imaging technology, and in particularly to a non-uniform excitation field-based method and system for performing a magnetic nanoparticle imaging. The present disclosure includes: separating the non-uniform excitation field into independent space and current time functions by a spatialtemporal separation method; calculating a normalized signal peak through the current time function; constructing a reconstruction mathematical model based on the normalized signal peak and an imaging subunit volume; and quantitatively reconstructing a spatial distribution of a nanoparticle by combining the normalized signal peak, a non-uniform spatial function of the excitation field and the reconstruction mathematical model, so as to achieve the magnetic nanoparticle imaging of a to-be-reconstructed object.