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    ORGANIC COMPOUNDS
    1.
    发明申请
    ORGANIC COMPOUNDS 审中-公开
    有机化合物

    公开(公告)号：US20150080357A1

    公开(公告)日：2015-03-19

    申请号：US14296145

    申请日：2014-06-04

    Applicant: INTRA-CELLULAR THERAPIES, INC.

    Inventor： Peng LI ,  Jun ZHAO ,  Hailin ZHENG ,  Lawrence WENNOGLE

    IPC: C07D487/14 ,  A61K31/5575 ,  A61K31/519

    CPC classification number: C07D487/14 ,  A61K31/519 ,  A61K31/5575 ,  A61K45/06

    Abstract: Optionally substituted 4,5,7,8-tetrahydro-(optionally 4-thioxo or 4-imino)-(1H or 2H)-imidazo[1,2-a]pyrazolo[4,3-e]pyrimidine or 4,5,7,8,9-pentahydro-(optionally 4-thioxo or 4-imino)-(1H or 2H)-pyrimido[1,2-a]pyrazolo[4,3-e]pyrimidine compounds or Compounds of Formula (I), processes for their production, their use as pharmaceuticals and pharmaceutical compositions comprising them.

    Abstract translation: 任选取代的4,5,7,8-四氢 - （任选4-硫代或4-亚氨基） - （1H或2H） - 咪唑并[1,2-a]吡唑并[4,3-e]嘧啶或4,5 ，7,8,9-五氢 - （任选的4-硫代或4-亚氨基） - （1H或2H） - 嘧啶并[1,2-a]吡唑并[4,3-e]嘧啶化合物或式 ），其生产方法，它们作为药物的用途以及包含它们的药物组合物。

    ORGANIC COMPOUNDS
    2.
    发明申请
    ORGANIC COMPOUNDS 审中-公开
    有机化合物

    公开(公告)号：US20140148421A1

    公开(公告)日：2014-05-29

    申请号：US14169352

    申请日：2014-01-31

    Applicant: INTRA-CELLULAR THERAPIES, INC.

    Inventor： Peng LI ,  Jun ZHAO ,  Hailin ZHENG ,  Lawrence WENNOGLE

    IPC: A61K31/519 ,  A61K45/06 ,  C07D487/14

    CPC classification number: C07D487/14 ,  A61K31/165 ,  A61K31/519 ,  A61K31/5365 ,  A61K45/06

    Abstract: Optionally substituted 4,5,7,8-tetrahydro-(optionally 4-oxo, 4-thioxo or 4-imino)-2H-imidazo[1,2-a]pyrrolo[3,4-e]pyrimidine or 4,5,7,8,9-pentahydro-(optionally 4-oxo, 4-thioxo or 4-imino)-2H-pyrimido[1,2-a]pyrrolo[3,4-e]pyrimidine compounds or Compounds of Formula (I), processes for their production, their use as pharmaceuticals and pharmaceutical compositions comprising the same.

    Abstract translation: 任选取代的4,5,7,8-四氢 - （任选4-氧代，4-硫代或4-亚氨基）-2H-咪唑并[1,2-a]吡咯并[3,4-e]嘧啶或4,5 ，7,8,9-五氢 - （任选4-氧代，4-硫代或4-亚氨基）-2H-嘧啶并[1,2-a]吡咯并[3,4-e]嘧啶化合物或式 ），其生产方法，它们作为药物的用途和包含其的药物组合物。

    NOVEL USES
    4.
    发明申请
    NOVEL USES 有权
    新用途

    公开(公告)号：US20160045507A1

    公开(公告)日：2016-02-18

    申请号：US14777448

    申请日：2014-03-17

    Applicant: INTRA-CELLULAR THERAPIES, INC.

    Inventor： Lawrence WENNOGLE

    IPC: A61K31/519 ,  A61K31/53 ,  A61K31/527

    CPC classification number: A61K31/519 ,  A61K31/517 ,  A61K31/527 ,  A61K31/53 ,  G01N33/84 ,  G01N2333/4727 ,  G01N2800/28

    Abstract: The subject matter generally relates to methods of treatment and/or prophylaxis of CNS diseases, disorders, and/or injuries. In one aspect, the subject matter relates to inhibitors of phosphodiesterase 1 (PDE1) as neuroprotective agents and/or neural regenerative agents. In a further aspect, the subject matter relates to individuals that are at risk for the development of CNS disease or disorder.

    Abstract translation: 主题通常涉及治疗和/或预防CNS疾病，障碍和/或损伤的方法。 一方面，本发明涉及磷酸二酯酶1（PDE1）作为神经保护剂和/或神经再生剂的抑制剂。 另一方面，该主题涉及处于CNS疾病或病症发展风险的个体。

    ORGANIC COMPOUNDS
    6.
    发明申请
    ORGANIC COMPOUNDS 审中-公开
    有机化合物

    公开(公告)号：US20150072965A1

    公开(公告)日：2015-03-12

    申请号：US14539859

    申请日：2014-11-12

    Applicant: Intra-Cellular Therapies, Inc.

    Inventor： Peng LI ,  Jun ZHAO ,  Hailin ZHENG ,  Lawrence WENNOGLE

    IPC: C07D487/14 ,  A61K45/06 ,  A61K31/165 ,  A61K31/519

    CPC classification number: C07D487/14 ,  A61K31/165 ,  A61K31/519 ,  A61K31/5365 ,  A61K45/06

    Abstract: Optionally substituted 4,5,7,8-tetrahydro-(optionally 4-oxo, 4-thioxo or 4-imino)-2H-imidazo[1,2-a]pyrrolo[3,4-e]pyrimidine or 4,5,7,8,9-pentahydro-(optionally 4-oxo, 4-thioxo or 4-imino)-2H-pyrimido[1,2-a]pyrrolo[3,4-e]pyrimidine compounds or Compounds of Formula (I), processes for their production, their use as pharmaceuticals and pharmaceutical compositions comprising the same.

    Abstract translation: 任选取代的4,5,7,8-四氢 - （任选4-氧代，4-硫代或4-亚氨基）-2H-咪唑并[1,2-a]吡咯并[3,4-e]嘧啶或4,5 ，7,8,9-五氢 - （任选4-氧代，4-硫代或4-亚氨基）-2H-嘧啶并[1,2-a]吡咯并[3,4-e]嘧啶化合物或式 ），其生产方法，它们作为药物的用途和包含其的药物组合物。

    COMPOUNDS AND METHODS
    9.
    发明申请
    COMPOUNDS AND METHODS 审中-公开

    公开(公告)号：US20170291904A1

    公开(公告)日：2017-10-12

    申请号：US15512005

    申请日：2015-09-17

    Applicant: INTRA-CELLULAR THERAPIES, INC.

    Inventor： Peng LI ,  Hailin ZHENG ,  Jun ZHAO ,  Lawrence WENNOGLE

    IPC: C07D487/14

    CPC classification number: C07D487/14

    Abstract: The subject matter generally relates to compounds and methods of treatment and/or prophylaxis of CNS diseases, disorders, and/or injuries. In one aspect, the subject matter relates to inhibitors of phosphodiesterase 1 (PDE1) as neuroprotective agents and/or neural regenerative agents. In a further aspect, the subject matter relates to individuals that are at risk for the development of CNS disease or disorder.

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