公开(公告)号：US20200046006A1

公开(公告)日：2020-02-13

申请号：US16060284

申请日：2016-12-08

Applicant: ISP Investments LLC

Inventor： Olga Dueva-Koganov ,  Michael Koganov ,  Paul Recht ,  Artyom Duev ,  Li Zhang ,  Steven Micceri ,  Robert Turner

IPC: A23L33/105 ,  A23L2/02 ,  A61K36/38

Abstract: The present invention provides bioactive serum fractions and bioactive extracts derived from an Achachairu (Garcinia humilis) plant. The bioactive serum fractions and bioactive extracts are free of or substantially free of benzophenone and/or free of or substantially free of proteins. The present invention also provides products comprising the bioactive serum fractions and/or bioactive extracts. The present invention further provides methods of making the bioactive serum fractions and/or bioactive extracts.

公开(公告)号：US11779624B2

公开(公告)日：2023-10-10

申请号：US17208700

申请日：2021-03-22

Applicant: ISP INVESTMENTS LLC

Inventor： Michael Koganov ,  Olga Dueva-Koganov ,  Artyom Duev ,  Steven Micceri

IPC: A61K36/73 ,  A61K36/752 ,  A61K36/81 ,  A61K36/88 ,  A61K36/185 ,  A61K36/45 ,  A61K36/736

CPC classification number: A61K36/73 ,  A61K36/185 ,  A61K36/45 ,  A61K36/736 ,  A61K36/752 ,  A61K36/81 ,  A61K36/88 ,  A61K2236/31 ,  A61K2236/37

Abstract: The present invention relates to composition comprising a bioactive fractions (ingredients) derived from fruit juice of an Apple (Pyrus malus) produced by processing the fresh fruit of apple under conditions effective to yield a bioactive fraction that is substantially free of protein and patulin. The present invention also relates to compositions having antioxidant and free radical scavenging properties and suitable for topical applications, oral applications and functional drink applications.

公开(公告)号：US20190231838A1

公开(公告)日：2019-08-01

申请号：US16376953

申请日：2019-04-05

Applicant: ISP INVESTMENTS LLC

Inventor： Michael KOGANOV ,  Olga Dueva-Koganov ,  Artyom Duev ,  Steven Micceri

IPC: A61K36/73 ,  A61K36/752 ,  A61K36/736 ,  A61K36/81 ,  A61K36/185 ,  A61K36/88 ,  A61K36/45

CPC classification number: A61K36/73 ,  A61K36/185 ,  A61K36/45 ,  A61K36/736 ,  A61K36/752 ,  A61K36/81 ,  A61K36/88 ,  A61K2236/31 ,  A61K2236/37

Abstract: The present invention relates to bioactive fractions (ingredients) derived from fruit juices. The bioactive fractions are either free of or substantially free of patulin and protein. Further, the bioactive fractions have antioxidant, free radical scavenging, moisturizing and buffering properties. The present invention also relates to a method for isolating bioactive fractions that are derived from fruit juices and are free or substantially free of protein and patulin. The present invention also relates to a method for preparing a bioactive fractions derived from fruit juices that are stabilized and are either free of or substantially free of patulin and protein.

公开(公告)号：US11766398B2

公开(公告)日：2023-09-26

申请号：US17504861

申请日：2021-10-19

Applicant: ISP INVESTMENTS LLC

Inventor： Olga Dueva-Koganov ,  Artyom Duev ,  Li Zhang ,  Karine Cucumel ,  Gilles Oberto

IPC: A61K8/9789 ,  A61Q19/08

CPC classification number: A61K8/9789 ,  A61Q19/08 ,  A61K2800/805 ,  A61K2800/81

Abstract: Disclosed herein are methods of improving skin appearance associated with skin aging. The method comprises the step of applying an anti-aging bioactive composition to a skin surface having at least one sign of aging. The anti-aging bioactive composition is applied for a period of time sufficient to improve the appearance of the at least one sign of aging. In one embodiment, the anti-aging bioactive composition comprises an effective amount of a Nelumbo nucifera (Sacred Lotus) serum fraction. In another embodiment, the anti-aging bioactive composition comprises an effective amount of a Chamomilla recutita (German Chamomile) Flower serum fraction. In other embodiments, the anti-aging bioactive composition can further include a dermatologically acceptable carrier.

公开(公告)号：US20220071892A1

公开(公告)日：2022-03-10

申请号：US17504861

申请日：2021-10-19

Applicant: ISP INVESTMENTS LLC

Inventor： Olga Dueva-Koganov ,  Artyom Duev ,  Li Zhang ,  Karine Cucumel ,  Gilles Oberto

IPC: A61K8/9789 ,  A61Q19/08

Abstract: Disclosed herein are methods of improving skin appearance associated with skin aging. The method comprises the step of applying an anti-aging bioactive composition to a skin surface having at least one sign of aging. The anti-aging bioactive composition is applied for a period of time sufficient to improve the appearance of the at least one sign of aging. In one embodiment, the anti-aging bioactive composition comprises an effective amount of a Nelumbo nucifera (Sacred Lotus) serum fraction. In another embodiment, the anti-aging bioactive composition comprises an effective amount of a Chamomilla recutita (German Chamomile) Flower serum fraction. In other embodiments, the anti-aging bioactive composition can further include a dermatologically acceptable carrier.

公开(公告)号：US11154493B2

公开(公告)日：2021-10-26

申请号：US16078925

申请日：2017-02-27

Applicant: ISP INVESTMENTS LLC

Inventor： Olga Dueva-Koganov ,  Artyom Duev ,  Li Zhang ,  Karine Cucumel ,  Gilles Oberto

IPC: A61K8/9789 ,  A61Q19/08

Abstract: Disclosed herein are methods of improving skin appearance associated with skin aging. The method comprises the step of applying an anti-aging bioactive composition to a skin surface having at least one sign of aging. The anti-aging bioactive composition is applied for a period of time sufficient to improve the appearance of the at least one sign of aging. In one embodiment, the anti-aging bioactive composition comprises an effective amount of a Nelumbo nucifera (Sacred Lotus) serum fraction. In another embodiment, the anti-aging bioactive composition comprises an effective amount of a Chamomilla recutita (German Chamomile) Flower serum fraction. In other embodiments, the anti-aging bioactive composition can further include a dermatologically acceptable carrier.

公开(公告)号：US11154492B2

公开(公告)日：2021-10-26

申请号：US16070391

申请日：2017-01-16

Applicant: ISP INVESTMENTS LLC

Inventor： Michael Koganov ,  Olga Dueva-Koganov ,  Paul Recht ,  Artyom Duev ,  Li Zhang ,  Steven Micceri ,  Robert Turner

IPC: A61K36/258 ,  A61K36/00 ,  A61K8/9789 ,  A61Q19/00 ,  A61Q19/10

Abstract: The present invention relates to bioactive compositions (including, for example, bioactive serum fractions and bioactive extracts) derived from ginseng (Panax spp.) fresh whole plant, a particular part of the plant (e.g., rhizome, roots, leaves, stems, flowers, fruit) or any combination of these plant parts. The bioactive serum fractions and bioactive extracts are free of or substantially free of pulegone and/or free of or substantially free of proteins. The present invention also provides products comprising the bioactive serum fractions and/or bioactive extracts. The present invention further provides methods of making and using the bioactive serum fractions and/or bioactive extracts. Further, the bioactive serum fractions and bioactive extracts have anti-inflammatory and/or anti-irritant and/or anti-aging activities.

公开(公告)号：US11000056B2

公开(公告)日：2021-05-11

申请号：US16060284

申请日：2016-12-08

Applicant: ISP Investments LLC

Inventor： Olga Dueva-Koganov ,  Michael Koganov ,  Paul Recht ,  Artyom Duev ,  Li Zhang ,  Steven Micceri ,  Robert Turner

IPC: A61K36/38 ,  A23L33/105 ,  A23L2/02

Abstract: The present invention provides bioactive serum fractions and bioactive extracts derived from an Achachairu (Garcinia humilis) plant. The bioactive serum fractions and bioactive extracts are free of or substantially free of benzophenone and/or free of or substantially free of proteins. The present invention also provides products comprising the bioactive serum fractions and/or bioactive extracts. The present invention further provides methods of making the bioactive serum fractions and/or bioactive extracts.

公开(公告)号：US10953061B2

公开(公告)日：2021-03-23

申请号：US16376953

申请日：2019-04-05

Applicant: ISP INVESTMENTS LLC

Inventor： Michael Koganov ,  Olga Dueva-Koganov ,  Artyom Duev ,  Steven Micceri

IPC: A61K36/73 ,  A61K36/752 ,  A61K36/81 ,  A61K36/88 ,  A61K36/185 ,  A61K36/45 ,  A61K36/736

Abstract: The present invention relates to bioactive fractions (ingredients) derived from fruit juices. The bioactive fractions are either free of or substantially free of patulin and protein. Further, the bioactive fractions have antioxidant, free radical scavenging, moisturizing and buffering properties. The present invention also relates to a method for isolating bioactive fractions that are derived from fruit juices and are free or substantially free of protein and patulin. The present invention also relates to a method for preparing a bioactive fractions derived from fruit juices that are stabilized and are either free of or substantially free of patulin and protein.