公开(公告)号：US20240293315A1

公开(公告)日：2024-09-05

申请号：US18572792

申请日：2022-06-21

申请人： IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY)

发明人： Kuen Yong LEE ,  Chunggoo KIM

IPC分类号： A61K9/107 ,  A61K9/00 ,  A61K9/46 ,  A61K33/00 ,  A61K47/10 ,  A61K47/42 ,  A61P3/04

CPC分类号： A61K9/107 ,  A61K9/0007 ,  A61K9/0019 ,  A61K33/00 ,  A61K47/10 ,  A61K47/42 ,  A61P3/04 ,  A61K2800/222

摘要： The present invention relates to a carbon dioxide-generating micelle. In the present invention, a micelle which uses a material with high biocompatibility and has a multi-arm structure capable of generating a large amount of carbon dioxide is produced, and thus, a greater amount of carbon dioxide can be generated, as compared to conventional polyethylene glycol-based micelles. In addition, in the present invention, intracellular penetration is improved by using a ligand (peptide), and thus, it is possible to target adipocytes and minimize effects on surrounding tissues and cells. The carbon dioxide-generating micelle according to the present invention can be produced as an injectable preparation, and can be applied to local lipolysis supplements or diet and beauty products that break down localized fat.