公开(公告)号：US07282509B2

公开(公告)日：2007-10-16

申请号：US11087167

申请日：2005-03-23

申请人： Ian Irwin ,  Monica Palme ,  Cyrus Becker ,  Courtney Rubens ,  Pascal Druzgala

发明人： Ian Irwin ,  Monica Palme ,  Cyrus Becker ,  Courtney Rubens ,  Pascal Druzgala

IPC分类号： C07D211/56 ,  C07D211/92 ,  A01N43/40 ,  A61K31/445

CPC分类号： C07D453/02 ,  A61K31/4745 ,  C07D211/94 ,  C07D451/10

摘要： The subject invention provides stereoisomeric compounds of formula (X): wherein the variables are as defined herein, and compositions for the safe and effective treatment of various gastrointestinal disorders including, but not limited to, gastroparesis, gastroesophageal reflux and related conditions. The compounds of the subject invention are also useful in treating a variety of conditions involving the central nervous system.

公开(公告)号：US08093237B2

公开(公告)日：2012-01-10

申请号：US12047858

申请日：2008-03-13

申请人： Cyrus Becker ,  Courtney Rubens ,  Jason Adams ,  Monica Palme ,  Pascal Druzgala

发明人： Cyrus Becker ,  Courtney Rubens ,  Jason Adams ,  Monica Palme ,  Pascal Druzgala

IPC分类号： A61P25/00 ,  A61K31/553 ,  C07D267/02

CPC分类号： C07D413/04 ,  C07D405/14 ,  C07D453/02

摘要： The present invention relates to 11-(piperazin-1-yl)dibenzo[b,f][1,4 ]oxazapine compounds of the formula: where the variables are as defined herein, their salts and pharmaceutically acceptable compositions thereof. Methods of preparing these compounds are also described. These compounds may be used in the treatment of disorders such as schizophrenia, treatment resistant schizophrenia, bipolar disorder, psychotic depression, treatment resistant depression, schizophrenia-associated depression, treatment resistant OCD, autism, senile psychosis, psychotic dementia, L-DOPA induced psychosis, psychogenic polydipsia, psychotic symptoms of neurological disorders, sleep disorders.

摘要翻译： 本发明涉及下式的11-（哌嗪-1-基）二苯并[b，f] [1,4]恶唑氮化合物：其中变量如本文所定义，其盐和药学上可接受的组合物。 还描述了制备这些化合物的方法。 这些化合物可用于治疗精神分裂症，治疗耐药性精神分裂症，双相性精神障碍，精神病抑郁症，治疗耐药性抑郁症，精神分裂症相关抑郁症，治疗耐药性OCD，孤独症，老年性精神病，精神病性痴呆，L-DOPA诱发的精神病 ，心理性多饮，精神病性神经障碍症状，睡眠障碍。

公开(公告)号：US20120178738A1

公开(公告)日：2012-07-12

申请号：US13323183

申请日：2011-12-12

申请人： Cyrus Becker ,  Courtney Rubens ,  Jason Adams ,  Monica Palme ,  Pascal Druzgala

发明人： Cyrus Becker ,  Courtney Rubens ,  Jason Adams ,  Monica Palme ,  Pascal Druzgala

IPC分类号： A61K31/553 ,  A61P25/18 ,  A61P25/22 ,  A61P25/00 ,  A61P25/28 ,  C07D413/04 ,  A61P25/24

CPC分类号： C07D413/04 ,  C07D405/14 ,  C07D453/02

摘要： The present invention relates to 11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazapine compounds of the formula: where the variables are as defined herein, their salts and pharmaceutically acceptable compositions thereof. Methods of preparing these compounds are also described. These compounds may be used in the treatment of disorders such as schizophrenia, treatment resistant schizophrenia, bipolar disorder, psychotic depression, treatment resistant depression, schizophrenia-associated depression, treatment resistant OCD, autism, senile psychosis, psychotic dementia, L-DOPA induced psychosis, psychogenic polydipsia, psychotic symptoms of neurological disorders, sleep disorders.

摘要翻译： 本发明涉及下式的11-（哌嗪-1-基）二苯并[b，f] [1,4]恶唑氮化合物：其中变量如本文所定义，其盐和药学上可接受的组合物。 还描述了制备这些化合物的方法。 这些化合物可用于治疗精神分裂症，治疗耐药性精神分裂症，双相性精神障碍，精神病抑郁症，治疗耐药性抑郁症，精神分裂症相关抑郁症，治疗耐药性OCD，孤独症，老年性精神病，精神病性痴呆，L-DOPA诱发的精神病 ，心理性多饮，精神病性神经障碍症状，睡眠障碍。

公开(公告)号：US20080255088A1

公开(公告)日：2008-10-16

申请号：US12047858

申请日：2008-03-13

申请人： Cyrus Becker ,  Courtney Rubens ,  Jason Adams ,  Monica Palme ,  Pascal Druzgala

发明人： Cyrus Becker ,  Courtney Rubens ,  Jason Adams ,  Monica Palme ,  Pascal Druzgala

IPC分类号： A61K31/553 ,  C07D267/08 ,  A61P25/18

CPC分类号： C07D413/04 ,  C07D405/14 ,  C07D453/02

摘要： The present invention relates to 11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazapine compounds of the formula: where the variables are as defined herein, their salts and pharmaceutically acceptable compositions thereof. Methods of preparing these compounds are also described. These compounds may be used in the treatment of disorders such as schizophrenia, treatment resistant schizophrenia, bipolar disorder, psychotic depression, treatment resistant depression, schizophrenia-associated depression, treatment resistant OCD, autism, senile psychosis, psychotic dementia, L-DOPA induced psychosis, psychogenic polydipsia, psychotic symptoms of neurological disorders, sleep disorders.

摘要翻译： 本发明涉及下式的11-（哌嗪-1-基）二苯并[b，f] [1,4]恶唑氮化合物：其中变量如本文所定义，其盐和药学上可接受的组合物。 还描述了制备这些化合物的方法。 这些化合物可用于治疗精神分裂症，治疗耐药性精神分裂症，双相性精神障碍，精神病抑郁症，治疗耐药性抑郁症，精神分裂症相关抑郁症，治疗耐药性OCD，孤独症，老年性精神病，精神病性痴呆，L-DOPA诱发的精神病 ，心理性多饮，精神病性神经障碍症状，睡眠障碍。

公开(公告)号：US20130040987A1

公开(公告)日：2013-02-14

申请号：US13370853

申请日：2012-02-10

申请人： Ian Irwin ,  Monica Palme ,  Cyrus Becker ,  Pascal Druzgala

发明人： Ian Irwin ,  Monica Palme ,  Cyrus Becker ,  Pascal Druzgala

IPC分类号： A61K31/439 ,  A61P1/08 ,  A61P1/00 ,  A61P1/10 ,  A61P1/04 ,  C07D453/02 ,  A61P1/14

CPC分类号： C07D453/02 ,  C07D401/04

摘要： The subject invention provides stereoisomeric compounds of formula (X): wherein the variables are as defined herein, and compositions for the safe and effective treatment of various gastrointestinal disorders including, but not limited to, gastroparesis, gastroesophageal reflux and related conditions. The compounds of the subject invention are also useful in treating a variety of conditions involving the central nervous system.

摘要翻译： 本发明提供式（X）的立体异构体化合物：其中变量如本文所定义，以及用于安全和有效治疗各种胃肠道疾病的组合物，包括但不限于胃轻瘫，胃食管反流和相关病症。 本发明的化合物还可用于治疗涉及中枢神经系统的多种病症。

公开(公告)号：US08138204B2

公开(公告)日：2012-03-20

申请号：US11778315

申请日：2007-07-16

申请人： Ian Irwin ,  Monica Palme ,  Cyrus Becker ,  Pascal Druzgala

发明人： Ian Irwin ,  Monica Palme ,  Cyrus Becker ,  Pascal Druzgala

IPC分类号： A61K31/4468 ,  A61K31/439

CPC分类号： C07D453/02 ,  C07D401/04

摘要： The subject invention provides stereoisomeric compounds of formula (X): wherein the variables are as defined herein, and compositions for the safe and effective treatment of various gastrointestinal disorders including, but not limited to, gastroparesis, gastroesophageal reflux and related conditions. The compounds of the subject invention are also useful in treating a variety of conditions involving the central nervous system.

摘要翻译： 本发明提供式（X）的立体异构体化合物：其中变量如本文所定义，以及用于安全和有效治疗各种胃肠道疾病的组合物，包括但不限于胃轻瘫，胃食管反流和相关病症。 本发明的化合物还可用于治疗涉及中枢神经系统的多种病症。

公开(公告)号：US08524736B2

公开(公告)日：2013-09-03

申请号：US13370853

申请日：2012-02-10

申请人： Ian Irwin ,  Monica Palme ,  Cyrus Becker ,  Pascal J. Druzgala

发明人： Ian Irwin ,  Monica Palme ,  Cyrus Becker ,  Pascal J. Druzgala

IPC分类号： C07D453/02

CPC分类号： C07D453/02 ,  C07D401/04

摘要： The subject invention provides stereoisomeric compounds of formula (X): wherein the variables are as defined herein, and compositions for the safe and effective treatment of various gastrointestinal disorders including, but not limited to, gastroparesis, gastroesophageal reflux and related conditions. The compounds of the subject invention are also useful in treating a variety of conditions involving the central nervous system.

摘要翻译： 本发明提供式（X）的立体异构体化合物：其中变量如本文所定义，以及用于安全和有效治疗各种胃肠道疾病的组合物，包括但不限于胃轻瘫，胃食管反流和相关病症。 本发明的化合物还可用于治疗涉及中枢神经系统的多种病症。

公开(公告)号：US07176218B2

公开(公告)日：2007-02-13

申请号：US11031623

申请日：2005-01-07

申请人： Ian Irwin ,  Monica Palme ,  Cyrus Becker

发明人： Ian Irwin ,  Monica Palme ,  Cyrus Becker

IPC分类号： A01N43/90 ,  A61K31/44 ,  C07D453/02

CPC分类号： C07D453/02 ,  A61K31/4745 ,  C07D211/94 ,  C07D451/10

摘要： The subject invention provides stereoisomeric compounds of formula (X): wherein the variables are as defined herein, and compositions for the safe and effective treatment of various gastrointestinal disorders including, but not limited to, gastroparesis, gastroesophageal reflux and related conditions. The compounds of the subject invention are also useful in treating a variety of conditions involving the central nervous system.

摘要翻译： 本发明提供式（X）的立体异构体化合物：其中变量如本文所定义，以及用于安全和有效治疗各种胃肠道疾病的组合物，包括但不限于胃轻瘫，胃食管反流和相关病症。 本发明的化合物还可用于治疗涉及中枢神经系统的多种病症。

公开(公告)号：US20050197363A1

公开(公告)日：2005-09-08

申请号：US11087167

申请日：2005-03-23

申请人： Ian Irwin ,  Monica Palme ,  Cyrus Becker

发明人： Ian Irwin ,  Monica Palme ,  Cyrus Becker

IPC分类号： A61K31/4745 ,  C07D211/94 ,  C07D451/10 ,  C07D453/02 ,  A61K31/454 ,  C07D43/02

CPC分类号： C07D453/02 ,  A61K31/4745 ,  C07D211/94 ,  C07D451/10

摘要： The subject invention provides stereoisomeric compounds of formula (X): wherein the variables are as defined herein, and compositions for the safe and effective treatment of various gastrointestinal disorders including, but not limited to, gastroparesis, gastroesophageal reflux and related conditions. The compounds of the subject invention are also useful in treating a variety of conditions involving the central nervous system.

摘要翻译： 本发明提供式（X）的立体异构体化合物：其中变量如本文所定义，以及用于安全和有效治疗各种胃肠道疾病的组合物，包括但不限于胃轻瘫，胃食管反流和相关病症。 本发明的化合物还可用于治疗涉及中枢神经系统的多种病症。

公开(公告)号：US20050176757A1

公开(公告)日：2005-08-11

申请号：US11031623

申请日：2005-01-07

申请人： Ian Irwin ,  Monica Palme ,  Cyrus Becker

发明人： Ian Irwin ,  Monica Palme ,  Cyrus Becker

IPC分类号： A61K31/4745 ,  C07D211/94 ,  C07D451/10 ,  C07D453/02 ,  C07D453/04

CPC分类号： C07D453/02 ,  A61K31/4745 ,  C07D211/94 ,  C07D451/10

摘要： The subject invention provides stereoisomeric compounds of formula (X): wherein the variables are as defined herein, and compositions for the safe and effective treatment of various gastrointestinal disorders including, but not limited to, gastroparesis, gastroesophageal reflux and related conditions. The compounds of the subject invention are also useful in treating a variety of conditions involving the central nervous system.