专利检索 ap:("Idenix Pharmaceuticals LLC" OR "Universita Degli Studi Di Cagliari") AND inv:"David N. Standring" 第 1 页

1.

发明授权
2′-branched nucleosides and flaviviridae mutation 有权

公开(公告)号：US10525072B2

公开(公告)日：2020-01-07

申请号：US14972009

申请日：2015-12-16

申请人： Idenix Pharmaceuticals LLC , Universita Degli Studi Di Cagliari

发明人： Jean-Pierre Sommadossi , Paolo La Colla , David N. Standring , Vadim Bichko , Lin Qu

IPC分类号： C12Q1/70 , A61K31/7072 , A61K31/7052 , A61K38/21 , A61K45/06 , C07H19/06 , C07H19/16 , C07K14/005 , C12Q1/04 , C12Q1/18

摘要： The present invention discloses a method for the treatment of Flaviviridae infection that includes the administration of a 2′-branched nucleoside, or a pharmaceutically acceptable prodrug and/or salt thereof, to a human in need of therapy in combination or alternation with a drug that directly or indirectly induces a mutation in the viral genome at a location other than a mutation of a nucleotide that results in a change from serine to a different amino acid in the highly conserved consensus sequence, XRXSGXXXT (SEQ ID NO: 63), of domain B of the RNA polymerase region, or is associated with such a mutation. The invention also includes a method to detect a mutant strain of Flaviviridae and a method for its treatment.