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1.发明授权Method of screening for agents that modulate Tysnd1 level or activity in a cell. 失效筛选调节细胞中Tysnd1水平或活性的试剂的方法。公开(公告)号：US07605005B2
公开(公告)日：2009-10-20
申请号：US12000158
申请日：2007-12-10
CPC分类号： A61K38/48 , C07K16/40 , G01N33/6893 , G01N2333/8139
摘要： The invention relates to a pharmaceutical composition for treating or diagnosing a disorder associated with production of peroxisome in a cell, comprising a polypeptide which has cysteine protease activity and directly processes peroxisomal enzymes targeted by PTS1 or PTS2 signals. Preferably, the polypeptide is encoded by Tysnd1.
摘要翻译： 本发明涉及一种用于治疗或诊断与细胞中过氧化物酶体生成相关的病症的药物组合物，其包含具有半胱氨酸蛋白酶活性并直接加工由PTS1或PTS2信号靶向的过氧化物酶的多肽。 优选地，多肽由Tysnd1编码。
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2.发明申请Pharmaceutical composition for treating and diagnosing a disorder associated with peroxisomal biogenesis and function 失效用于治疗和诊断与过氧化物酶体生物发生和功能相关的病症的药物组合物公开(公告)号：US20080160023A1
公开(公告)日：2008-07-03
申请号：US12000158
申请日：2007-12-10
IPC分类号： A61K39/395 , C12Q1/37 , A61P3/04 , A61P9/10
CPC分类号： A61K38/48 , C07K16/40 , G01N33/6893 , G01N2333/8139
摘要： The invention relates to a pharmaceutical composition for treating or diagnosing a disorder associated with production of peroxisome in a cell, comprising a polypeptide which has cysteine protease activity and directly processes peroxisomal enzymes targeted by PTS1 or PTS2 signals. Preferably, the polypeptide is encoded by Tysnd1.
摘要翻译： 本发明涉及一种用于治疗或诊断与细胞中过氧化物酶体生成相关的病症的药物组合物，其包含具有半胱氨酸蛋白酶活性并直接加工由PTS1或PTS2信号靶向的过氧化物酶的多肽。 优选地，多肽由Tysnd1编码。
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