公开(公告)号：US09738690B2

公开(公告)日：2017-08-22

申请号：US14234065

申请日：2012-07-23

申请人： Ilijas Jelcic ,  Roland Martin ,  Sven Schippling ,  Mireia Sospedra ,  Sara Yousef

发明人： Ilijas Jelcic ,  Roland Martin ,  Sven Schippling ,  Mireia Sospedra ,  Sara Yousef

IPC分类号： C12Q1/70 ,  C07K14/005 ,  A61K39/12 ,  A61K38/20 ,  C07K7/08 ,  A61K38/16 ,  A61K38/00 ,  C12N7/00 ,  A61K39/00

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K38/162 ,  A61K38/2046 ,  A61K39/12 ,  A61K2039/55511 ,  A61K2039/55527 ,  C07K7/08 ,  C12N7/00 ,  C12N2710/22022 ,  C12N2710/22023 ,  C12N2710/22034 ,  C12N2710/22071 ,  C12Q1/70

摘要： The present invention relates to the field of vaccination or immunization, in particular therapeutic vaccination, and diagnosis. Pharmaceutical compositions and kits capable of eliciting a protective immune response against polyoma virus JC (JCV) are disclosed, which may be used e.g., for therapy or for prevention of progressive multifocal leukoencephalopathy (PML) and/or progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome (PML-IRIS). Individuals in danger of such PML or PML-IRIS may, e.g., be immuno-compromised or immunosuppressed patients or patients having an autoimmune disease eligible for immunosuppressive treatment. The invention also relates to compositions comprising at least one CD4+ epitope of a JCV protein and to therapeutic, prophylactic and diagnostic uses thereof.

公开(公告)号：US20140356320A1

公开(公告)日：2014-12-04

申请号：US14234065

申请日：2012-07-23

申请人： Ilijas Jelcic ,  Roland Martin ,  Sven Schippling ,  Mireia Sospedra ,  Sara Yousef

发明人： Ilijas Jelcic ,  Roland Martin ,  Sven Schippling ,  Mireia Sospedra ,  Sara Yousef

IPC分类号： C07K14/005 ,  A61K38/20 ,  A61K39/12 ,  C07K7/08 ,  C12Q1/70

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K38/162 ,  A61K38/2046 ,  A61K39/12 ,  A61K2039/55511 ,  A61K2039/55527 ,  C07K7/08 ,  C12N7/00 ,  C12N2710/22022 ,  C12N2710/22023 ,  C12N2710/22034 ,  C12N2710/22071 ,  C12Q1/70

摘要： The present invention relates to the field of vaccination or immunization, in particular therapeutic vaccination, and diagnosis. Pharmaceutical compositions and kits capable of eliciting a protective immune response against polyoma virus JC (JCV) are disclosed, which may be used e.g., for therapy or for prevention of progressive multifocal leukoencephalopathy (PML) and/or progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome (PML-IRIS). Individuals in danger of such PML or PML-IRIS may, e.g., be immuno-compromised or immunosuppressed patients or patients having an autoimmune disease eligible for immunosuppressive treatment. The invention also relates to compositions comprising at least one CD4+ epitope of a JCV protein and to therapeutic, prophylactic and diagnostic uses thereof.

摘要翻译： 本发明涉及疫苗接种或免疫领域，特别是治疗性疫苗接种和诊断领域。 公开了能够引起针对多瘤病毒JC（JCV）的保护性免疫应答的药物组合物和试剂盒，其可用于治疗或预防进行性多灶性脑白质脑病（PML）和/或进行性多灶性脑白质脑病 - 免疫重建炎症综合征 （PML-IRIS）。 患有这种PML或PML-IRIS的危险的个体可以例如是免疫受损的或免疫抑制的患者或具有适合免疫抑制治疗的自身免疫疾病的患者。 本发明还涉及包含至少一种JCV蛋白的CD4 +表位的组合物及其治疗，预防和诊断用途。