公开(公告)号：US09743660B2

公开(公告)日：2017-08-29

申请号：US13529024

申请日：2012-06-21

申请人： Ilya Ilyin ,  Semyon Kogan ,  William E. Grieshober, Jr. ,  Igor Kachko ,  Vladimir Vasiliev ,  Stanislav A. Kolchanov ,  Yuriy Punin ,  Mark Bakhrakh ,  Alexander N. Shumeev

发明人： Ilya Ilyin ,  Semyon Kogan ,  William E. Grieshober, Jr. ,  Igor Kachko ,  Vladimir Vasiliev ,  Stanislav A. Kolchanov ,  Yuriy Punin ,  Mark Bakhrakh ,  Alexander N. Shumeev

IPC分类号： A61B19/00 ,  A01N1/02 ,  A61J1/10 ,  A61J1/16

CPC分类号： A01N1/021 ,  A01N1/0242 ,  A01N1/0263 ,  A01N1/0289 ,  A61J1/10 ,  A61J1/16

摘要： A system, method, and device for preserving blood and its components is described. The system and method generally include a device having a body defining a chamber, the chamber being configured to receive at least one bag containing blood or its components, the at least one bag being permeable to gas, for example, xenon. A cover is hermetically sealable to the body. An inlet is in fluid communication with the chamber. A pressure indicator is configured to indicate pressure in the chamber, the pressure indicator including a conduit containing a liquid. A portion of the conduit is transparent such that the liquid is visible. A source of pressurized gas, such as xenon, is provided to provide the pressurized gas to the chamber.

公开(公告)号：US20130157249A1

公开(公告)日：2013-06-20

申请号：US13529024

申请日：2012-06-21

申请人： Ilya Ilyin ,  Semyon Kogan ,  William E. Grieshober, JR. ,  Igor Kachko ,  Vladimir Vasiliev ,  Stanislav A. Kolchanov ,  Yuriy Punin ,  Mark Bakhrakh ,  Alexander N. Shumeev

发明人： Ilya Ilyin ,  Semyon Kogan ,  William E. Grieshober, JR. ,  Igor Kachko ,  Vladimir Vasiliev ,  Stanislav A. Kolchanov ,  Yuriy Punin ,  Mark Bakhrakh ,  Alexander N. Shumeev

IPC分类号： A01N1/02

CPC分类号： A01N1/021 ,  A01N1/0242 ,  A01N1/0263 ,  A01N1/0289 ,  A61J1/10 ,  A61J1/16

摘要： A system, method, and device for preserving blood and its components is described. The system and method generally include a device having a body defining a chamber, the chamber being configured to receive at least one bag containing blood or its components, the at least one bag being permeable to gas, for example, xenon. A cover is hermetically sealable to the body. An inlet is in fluid communication with the chamber. A pressure indicator is configured to indicate pressure in the chamber, the pressure indicator including a conduit containing a liquid. A portion of the conduit is transparent such that the liquid is visible. A source of pressurized gas, such as xenon, is provided to provide the pressurized gas to the chamber.

摘要翻译： 描述了一种用于保存血液及其组分的系统，方法和装置。 该系统和方法通常包括具有限定腔室的主体的装置，所述腔室构造成容纳至少一个含有血液或其组分的袋，所述至少一个袋子可渗透气体，例如氙气。 盖子对身体密封。 入口与腔室流体连通。 压力指示器构造成指示腔室中的压力，压力指示器包括含有液体的导管。 导管的一部分是透明的，使得液体是可见的。 提供诸如氙气的加压气体源，以将加压气体提供给腔室。

公开(公告)号：US20130344596A1

公开(公告)日：2013-12-26

申请号：US13982766

申请日：2012-02-03

申请人： William E. Grieshober, JR. ,  James S. Jones ,  Semyon Kogan ,  Ilya Ilyin ,  Natella I. Enukashvily ,  Yana A. Filkina ,  Alexander N. Shumeev ,  Stanislav Kolchanov

发明人： William E. Grieshober, JR. ,  James S. Jones ,  Semyon Kogan ,  Ilya Ilyin ,  Natella I. Enukashvily ,  Yana A. Filkina ,  Alexander N. Shumeev ,  Stanislav Kolchanov

IPC分类号： A01N1/02

CPC分类号： A01N1/0284 ,  A01N1/0289

摘要： Provided is a method for reducing apoptosis in nucleated cells. The method entails holding nucleated cells in a container and adding a gas containing xenon to the container so that the pressure inside the container reaches between 0.5 to 4.0 Atm above ambient pressure; holding the container at between 0.5 to 4.0 Atm above ambient pressure for a period of time during which the temperature in the container is between 22° C. and 37° C.; lowering the temperature in the container to between 0.1° C. and 10° C. while maintaining the pressure of 0.5 to 4.0 Atm above ambient pressure and holding the container for a period of time; and reducing the pressure in the container to ambient pressure and increasing the temperature to 22° C.-37° C. By performing these steps, the cells undergo less apoptosis than a reference.

摘要翻译： 提供了一种减少有核细胞凋亡的方法。 该方法需要将有核细胞保持在容器中，并将含有氙气体添加到容器中，使得容器内的压力达到高于环境压力的0.5至4.0atm; 将容器保持在高于环境压力的0.5至4.0atm之间一段时间，在此期间容器中的温度在22℃至37℃之间; 将容器中的温度降至0.1℃至10℃之间，同时保持高于环境压力的0.5至4.0atm的压力并将容器保持一段时间; 并将容器中的压力降低至环境压力，并将温度升高至22℃-37℃。通过进行这些步骤，细胞比参考物细胞凋亡更少。

公开(公告)号：US10098340B2

公开(公告)日：2018-10-16

申请号：US13982766

申请日：2012-02-03

申请人： William E. Grieshober, Jr. ,  James S. Jones ,  Semyon Kogan ,  Ilya Ilyin ,  Natella I. Enukashvily ,  Yana A. Filkina ,  Alexander N. Shumeev ,  Stanislav Kolchanov

发明人： William E. Grieshober, Jr. ,  James S. Jones ,  Semyon Kogan ,  Ilya Ilyin ,  Natella I. Enukashvily ,  Yana A. Filkina ,  Alexander N. Shumeev ,  Stanislav Kolchanov

IPC分类号： A01N1/02

摘要： Provided is a method for reducing apoptosis in nucleated cells. The method entails holding nucleated cells in a container and adding a gas containing xenon to the container so that the pressure inside the container reaches between 0.5 to 4.0 Atm above ambient pressure; holding the container at between 0.5 to 4.0 Atm above ambient pressure for a period of time during which the temperature in the container is between 22° C. and 37° C.; lowering the temperature in the container to between 0.1° C. and 10° C. while maintaining the pressure of 0.5 to 4.0 Atm above ambient pressure and holding the container for a period of time; and reducing the pressure in the container to ambient pressure and increasing the temperature to 22° C.-37° C. By performing these steps, the cells undergo less apoptosis than a reference.

公开(公告)号：US08158084B2

公开(公告)日：2012-04-17

申请号：US12903027

申请日：2010-10-12

申请人： Edward B. Rinker ,  Janet Elizabeth Lane ,  Simon S. Litvin ,  Ilya Ilyin ,  Alexander Chaliyan ,  Dmitry Logatchev ,  Michael Gershman ,  Valery Pavlov ,  Semyon Kogan

发明人： Edward B. Rinker ,  Janet Elizabeth Lane ,  Simon S. Litvin ,  Ilya Ilyin ,  Alexander Chaliyan ,  Dmitry Logatchev ,  Michael Gershman ,  Valery Pavlov ,  Semyon Kogan

IPC分类号： B01L3/02

CPC分类号： C02F1/00 ,  A23L2/52 ,  A23L33/10 ,  C02F1/001 ,  C02F1/68 ,  C02F2209/006 ,  Y10T137/794

摘要： An enhancement control system that can be used as part of an enhanced water system to produce enhanced filtered water is described. The enhancement control system includes at least one enhancement delivery element that can dispense an enhancement(s) into filtered water in response to an enhancement delivery instruction(s). The enhancement control system can also include an input element that can enable transmittal of the enhancement delivery instruction(s) from a user to the enhancement delivery element(s). The control system can also include a memory element that can store information about the user and the user's preferences and information about the enhanced water system. The control system can also include a communication element that can provide information from the enhanced water system to the user. The control system can also include a monitor element that can gather data from outside the enhanced water system, such as user health information or environmental information, and provide the data to the enhanced water system. In some embodiments, a control logic element can be used to coordinate and control operation of the elements of the enhanced water system.

摘要翻译： 描述了可以用作增强水系统的一部分以产生增强的过滤水的增强控制系统。 该增强控制系统包括至少一个增强递送元件，其可以响应于增强递送指令而将增强分配到经过过滤的水中。 增强控制系统还可以包括输入元件，其可以使得能够将用户的增强传递指令传送到增强传递元件。 控制系统还可以包括可以存储关于用户的信息和用户偏好的信息的存储元件以及关于增强的水系统的信息。 控制系统还可以包括可以从增强的水系统向用户提供信息的通信元件。 控制系统还可以包括可以从增强水系统外部收集数据的监视元件，例如用户健康信息或环境信息，并将数据提供给增强的水系统。 在一些实施例中，可以使用控制逻辑元件来协调和控制增强水系统的元件的操作。

公开(公告)号：US08309030B2

公开(公告)日：2012-11-13

申请号：US12720069

申请日：2010-03-09

申请人： Edward B. Rinker ,  Simon Litvin ,  Semyon Kogan ,  Ilya Ilyin ,  Alexander Chaliyan ,  Dmitry Logatchev ,  Valery Pavlov ,  Michael Gershman

发明人： Edward B. Rinker ,  Simon Litvin ,  Semyon Kogan ,  Ilya Ilyin ,  Alexander Chaliyan ,  Dmitry Logatchev ,  Valery Pavlov ,  Michael Gershman

IPC分类号： B01L3/02

CPC分类号： C02F1/00 ,  A23L2/52 ,  A23L33/10 ,  C02F1/001 ,  C02F1/68 ,  C02F2209/006 ,  Y10T137/794

摘要： An enhancement control system that can be used as part of an enhanced water system to produce enhanced filtered water is described. The enhancement control system includes at least one enhancement delivery element that can dispense an enhancement(s) into filtered water in response to an enhancement delivery instruction(s). The enhancement control system can also include an input element that can enable transmittal of the enhancement delivery instruction(s) from a user to the enhancement delivery element(s). The control system can also include a memory element that can store information about the user and the user's preferences and information about the enhanced water system. The control system can also include a communication element that can provide information from the enhanced water system to the user. The control system can also include a monitor element that can gather data from outside the enhanced water system, such as user health information or environmental information, and provide the data to the enhanced water system. In some embodiments, a control logic element can be used to coordinate and control operation of the elements of the enhanced water system.

公开(公告)号：US20050133420A1

公开(公告)日：2005-06-23

申请号：US11015395

申请日：2004-12-16

申请人： Edward Rinker ,  Simon Litvin ,  Semyon Kogan ,  Ilya Ilyin ,  Alexander Chaliyan ,  Dmitry Logatchev ,  Valery Pavlov ,  Michael Gershman

发明人： Edward Rinker ,  Simon Litvin ,  Semyon Kogan ,  Ilya Ilyin ,  Alexander Chaliyan ,  Dmitry Logatchev ,  Valery Pavlov ,  Michael Gershman

IPC分类号： B01D3/00 ,  B01D17/12 ,  G05B21/00

CPC分类号： C02F1/00 ,  A23L2/52 ,  A23L33/10 ,  C02F1/001 ,  C02F1/68 ,  C02F2209/006 ,  Y10T137/794

摘要： An enhancement control system that can be used as part of an enhanced water system to produce enhanced filtered water is described. The enhancement control system includes at least one enhancement delivery element that can dispense an enhancement(s) into filtered water in response to an enhancement delivery instruction(s). The enhancement control system can also include an input element that can enable transmittal of the enhancement delivery instruction(s) from a user to the enhancement delivery element(s). The control system can also include a memory element that can store information about the user and the user's preferences and information about the enhanced water system. The control system can also include a communication element that can provide information from the enhanced water system to the user. The control system can also include a monitor element that can gather data from outside the enhanced water system, such as user health information or environmental information, and provide the data to the enhanced water system. In some embodiments, a control logic element can be used to coordinate and control operation of the elements of the enhanced water system.

摘要翻译： 描述了可以用作增强水系统的一部分以产生增强的过滤水的增强控制系统。 该增强控制系统包括至少一个增强递送元件，其可以响应于增强递送指令而将增强分配到经过过滤的水中。 增强控制系统还可以包括输入元件，其可以使得能够将用户的增强传递指令传送到增强传递元件。 控制系统还可以包括可以存储关于用户的信息和用户偏好的信息的存储元件以及关于增强的水系统的信息。 控制系统还可以包括可以从增强的水系统向用户提供信息的通信元件。 控制系统还可以包括可以从增强水系统外部收集数据的监视元件，例如用户健康信息或环境信息，并将数据提供给增强的水系统。 在一些实施例中，可以使用控制逻辑元件来协调和控制增强水系统的元件的操作。

公开(公告)号：US20100166919A1

公开(公告)日：2010-07-01

申请号：US12720069

申请日：2010-03-09

申请人： Edward B. Rinker ,  Simon Litvin ,  Semyon Kogan ,  Ilya Ilyin ,  Alexander Chaliyan ,  Dmitry Logatchev ,  Valery Pavlov ,  Michael Gershman

发明人： Edward B. Rinker ,  Simon Litvin ,  Semyon Kogan ,  Ilya Ilyin ,  Alexander Chaliyan ,  Dmitry Logatchev ,  Valery Pavlov ,  Michael Gershman

IPC分类号： A47J31/46

CPC分类号： C02F1/00 ,  A23L2/52 ,  A23L33/10 ,  C02F1/001 ,  C02F1/68 ,  C02F2209/006 ,  Y10T137/794

摘要： An enhancement control system that can be used as part of an enhanced water system to produce enhanced filtered water is described. The enhancement control system includes at least one enhancement delivery element that can dispense an enhancement(s) into filtered water in response to an enhancement delivery instruction(s). The enhancement control system can also include an input element that can enable transmittal of the enhancement delivery instruction(s) from a user to the enhancement delivery element(s). The control system can also include a memory element that can store information about the user and the user's preferences and information about the enhanced water system. The control system can also include a communication element that can provide information from the enhanced water system to the user. The control system can also include a monitor element that can gather data from outside the enhanced water system, such as user health information or environmental information, and provide the data to the enhanced water system. In some embodiments, a control logic element can be used to coordinate and control operation of the elements of the enhanced water system.

摘要翻译： 描述了可以用作增强水系统的一部分以产生增强的过滤水的增强控制系统。 该增强控制系统包括至少一个增强递送元件，其可以响应于增强递送指令而将增强分配到经过过滤的水中。 增强控制系统还可以包括输入元件，其可以使得能够将用户的增强传递指令传送到增强传递元件。 控制系统还可以包括可以存储关于用户的信息和用户偏好的信息的存储元件以及关于增强的水系统的信息。 控制系统还可以包括可以从增强的水系统向用户提供信息的通信元件。 控制系统还可以包括可以从增强水系统外部收集数据的监视元件，例如用户健康信息或环境信息，并将数据提供给增强的水系统。 在一些实施例中，可以使用控制逻辑元件来协调和控制增强水系统的元件的操作。

公开(公告)号：US08480979B2

公开(公告)日：2013-07-09

申请号：US13419268

申请日：2012-03-13

申请人： Edward B. Rinker ,  Janet Elizabeth Lane ,  Simon S. Litvin ,  Ilya Ilyin ,  Alexander Chaliyan ,  Dmitry Logatchev ,  Michael Gershman ,  Valery Pavlov ,  Semyon Kogan

发明人： Edward B. Rinker ,  Janet Elizabeth Lane ,  Simon S. Litvin ,  Ilya Ilyin ,  Alexander Chaliyan ,  Dmitry Logatchev ,  Michael Gershman ,  Valery Pavlov ,  Semyon Kogan

IPC分类号： B01L3/02

CPC分类号： C02F1/00 ,  A23L2/52 ,  A23L33/10 ,  C02F1/001 ,  C02F1/68 ,  C02F2209/006 ,  Y10T137/794

摘要： An enhancement water system to produce a serving of enhanced filtered water is described. The present system describes a faucet mount water enhancement system that includes a housing with an inlet and an outlet, a source of water at the inlet, and a filter component within the housing. Source water is converted into treated water as it flows through the filter component under the influence of pressure. The housing further includes an outlet for outflow of treated water. A first enhancement module is disposed outside the housing adjacent the outlet and the first enhancement module is effective to dispense a desired amount of a first enhancement for use in combining with treated water dispensed from the outlet.

摘要翻译： 描述了一种用于生产增强的过滤水的增强水系统。 本系统描述了一种水龙头安装水增强系统，其包括具有入口和出口的壳体，入口处的水源和壳体内的过滤器部件。 源水在压力的影响下流过过滤器部件时被转化为处理过的水。 壳体还包括用于流出处理过的水的出口。 第一增强模块设置在邻近出口的壳体外部，并且第一增强模块有效地分配用于与从出口分配的处理水结合使用的期望量的第一增强。

公开(公告)号：US07713482B2

公开(公告)日：2010-05-11

申请号：US11015395

申请日：2004-12-16

申请人： Edward B. Rinker ,  Simon Litvin ,  Semyon Kogan ,  Ilya Ilyin ,  Alexander Chaliyan ,  Dmitry Logatchev ,  Valery Pavlov ,  Michael Gershman

发明人： Edward B. Rinker ,  Simon Litvin ,  Semyon Kogan ,  Ilya Ilyin ,  Alexander Chaliyan ,  Dmitry Logatchev ,  Valery Pavlov ,  Michael Gershman

IPC分类号： B01L99/00

CPC分类号： C02F1/00 ,  A23L2/52 ,  A23L33/10 ,  C02F1/001 ,  C02F1/68 ,  C02F2209/006 ,  Y10T137/794

摘要： An enhancement control system that can be used as part of an enhanced water system to produce enhanced filtered water is described. The enhancement control system includes at least one enhancement delivery element that can dispense an enhancement(s) into filtered water in response to an enhancement delivery instruction(s). The enhancement control system can also include an input element that can enable transmittal of the enhancement delivery instruction(s) from a user to the enhancement delivery element(s). The control system can also include a memory element that can store information about the user and the user's preferences and information about the enhanced water system. The control system can also include a communication element that can provide information from the enhanced water system to the user. The control system can also include a monitor element that can gather data from outside the enhanced water system, such as user health information or environmental information, and provide the data to the enhanced water system. In some embodiments, a control logic element can be used to coordinate and control operation of the elements of the enhanced water system.

摘要翻译： 描述了可以用作增强水系统的一部分以产生增强的过滤水的增强控制系统。 该增强控制系统包括至少一个增强递送元件，其可以响应于增强递送指令而将增强分配到经过过滤的水中。 增强控制系统还可以包括输入元件，其可以使得能够将用户的增强传递指令传送到增强传递元件。 控制系统还可以包括可以存储关于用户的信息和用户偏好的信息的存储元件以及关于增强的水系统的信息。 控制系统还可以包括可以从增强的水系统向用户提供信息的通信元件。 控制系统还可以包括可以从增强水系统外部收集数据的监视元件，例如用户健康信息或环境信息，并将数据提供给增强的水系统。 在一些实施例中，可以使用控制逻辑元件来协调和控制增强水系统的元件的操作。