公开(公告)号：US20130344596A1

公开(公告)日：2013-12-26

申请号：US13982766

申请日：2012-02-03

申请人： William E. Grieshober, JR. ,  James S. Jones ,  Semyon Kogan ,  Ilya Ilyin ,  Natella I. Enukashvily ,  Yana A. Filkina ,  Alexander N. Shumeev ,  Stanislav Kolchanov

发明人： William E. Grieshober, JR. ,  James S. Jones ,  Semyon Kogan ,  Ilya Ilyin ,  Natella I. Enukashvily ,  Yana A. Filkina ,  Alexander N. Shumeev ,  Stanislav Kolchanov

IPC分类号： A01N1/02

CPC分类号： A01N1/0284 ,  A01N1/0289

摘要： Provided is a method for reducing apoptosis in nucleated cells. The method entails holding nucleated cells in a container and adding a gas containing xenon to the container so that the pressure inside the container reaches between 0.5 to 4.0 Atm above ambient pressure; holding the container at between 0.5 to 4.0 Atm above ambient pressure for a period of time during which the temperature in the container is between 22° C. and 37° C.; lowering the temperature in the container to between 0.1° C. and 10° C. while maintaining the pressure of 0.5 to 4.0 Atm above ambient pressure and holding the container for a period of time; and reducing the pressure in the container to ambient pressure and increasing the temperature to 22° C.-37° C. By performing these steps, the cells undergo less apoptosis than a reference.

摘要翻译： 提供了一种减少有核细胞凋亡的方法。 该方法需要将有核细胞保持在容器中，并将含有氙气体添加到容器中，使得容器内的压力达到高于环境压力的0.5至4.0atm; 将容器保持在高于环境压力的0.5至4.0atm之间一段时间，在此期间容器中的温度在22℃至37℃之间; 将容器中的温度降至0.1℃至10℃之间，同时保持高于环境压力的0.5至4.0atm的压力并将容器保持一段时间; 并将容器中的压力降低至环境压力，并将温度升高至22℃-37℃。通过进行这些步骤，细胞比参考物细胞凋亡更少。

公开(公告)号：US08527290B2

公开(公告)日：2013-09-03

申请号：US13567164

申请日：2012-08-06

申请人： Praveen Upreti ,  Rohit Jalali ,  William E. Grieshober, Jr. ,  John S. Roberts ,  Melissa D. Haller ,  Michael Fuchs ,  Ilya Y. Ilyin

发明人： Praveen Upreti ,  Rohit Jalali ,  William E. Grieshober, Jr. ,  John S. Roberts ,  Melissa D. Haller ,  Michael Fuchs ,  Ilya Y. Ilyin

IPC分类号： G06Q10/00 ,  G06F17/00

CPC分类号： G06Q50/04 ,  G06Q10/06 ,  G06Q30/0206 ,  Y02P90/30

摘要： Flour may be treated to denature the proteins and modify starches. The invention includes methods and systems for determining whether to use treated flour or untreated flour. The invention also includes methods and systems for determining whether to treat flour or not.

摘要翻译： 可以对面粉进行处理以使蛋白质变性并改性淀粉。 本发明包括用于确定是否使用经处理的面粉或未处理的面粉的方法和系统。 本发明还包括用于确定是否处理面粉的方法和系统。

公开(公告)号：US09743660B2

公开(公告)日：2017-08-29

申请号：US13529024

申请日：2012-06-21

申请人： Ilya Ilyin ,  Semyon Kogan ,  William E. Grieshober, Jr. ,  Igor Kachko ,  Vladimir Vasiliev ,  Stanislav A. Kolchanov ,  Yuriy Punin ,  Mark Bakhrakh ,  Alexander N. Shumeev

发明人： Ilya Ilyin ,  Semyon Kogan ,  William E. Grieshober, Jr. ,  Igor Kachko ,  Vladimir Vasiliev ,  Stanislav A. Kolchanov ,  Yuriy Punin ,  Mark Bakhrakh ,  Alexander N. Shumeev

IPC分类号： A61B19/00 ,  A01N1/02 ,  A61J1/10 ,  A61J1/16

CPC分类号： A01N1/021 ,  A01N1/0242 ,  A01N1/0263 ,  A01N1/0289 ,  A61J1/10 ,  A61J1/16

摘要： A system, method, and device for preserving blood and its components is described. The system and method generally include a device having a body defining a chamber, the chamber being configured to receive at least one bag containing blood or its components, the at least one bag being permeable to gas, for example, xenon. A cover is hermetically sealable to the body. An inlet is in fluid communication with the chamber. A pressure indicator is configured to indicate pressure in the chamber, the pressure indicator including a conduit containing a liquid. A portion of the conduit is transparent such that the liquid is visible. A source of pressurized gas, such as xenon, is provided to provide the pressurized gas to the chamber.

公开(公告)号：US08870035B2

公开(公告)日：2014-10-28

申请号：US13565218

申请日：2012-08-02

申请人： Rohit Jalali ,  Christopher Vincent Tirone ,  Theodore Watson Rich ,  Steven A. Franz ,  William E. Grieshober, Jr. ,  Joseph Victor Bisacca ,  Lisa Augustine ,  Kerry Marshal Chace ,  Timothy A. Falken ,  David E. Moomaw

发明人： Rohit Jalali ,  Christopher Vincent Tirone ,  Theodore Watson Rich ,  Steven A. Franz ,  William E. Grieshober, Jr. ,  Joseph Victor Bisacca ,  Lisa Augustine ,  Kerry Marshal Chace ,  Timothy A. Falken ,  David E. Moomaw

IPC分类号： B67D7/64 ,  B05C17/005 ,  B05C17/01 ,  A23G3/28

CPC分类号： B05C17/0123 ,  A23G3/28 ,  B05C17/00583 ,  B05C17/0109

摘要： A dispensing device having a housing capable of receiving a pre-packaged charge of pre-whipped topping or icing. The housing has an inner wall with a slot formed therein for receiving a rack that is capable of rotational and translational motion within the slot. The rack has a set of gear teeth that engage with a catch on a plunger. The piston moves in the axial direction to force the pre-whipped topping or icing through the outlet in its packaging. The catch on the piston is locked in one direction and pivots in the opposite direction such that the rack engages with the piston when it moves in a first direction and the rack disengages with the piston when it is moved in a second direction opposite the first direction.

摘要翻译： 一种分配装置，其具有能够接收预先打包的顶部或结冰的预包装的容器的壳体。 壳体具有形成在其中的狭槽的内壁，用于容纳能够在槽内旋转和平移运动的齿条。 齿条具有与柱塞上的卡扣啮合的一组齿轮齿。 活塞在轴向方向上移动，以迫使预先鞭打的顶部或结冰通过其包装中的出口。 活塞上的卡扣在一个方向上被锁定并且沿相反方向枢转，使得当齿条沿着第一方向移动时齿条与活塞接合，并且当齿条沿着与第一方向相反的第二方向移动时，齿条与活塞脱离 。

公开(公告)号：US20090276268A1

公开(公告)日：2009-11-05

申请号：US12435286

申请日：2009-05-04

申请人： Praveen Upreti ,  Rohit Jalali ,  William E. Grieshober, JR. ,  John S. Roberts ,  Melissa D. Haller ,  Michael Fuchs ,  Ilya Y. Ilyin

发明人： Praveen Upreti ,  Rohit Jalali ,  William E. Grieshober, JR. ,  John S. Roberts ,  Melissa D. Haller ,  Michael Fuchs ,  Ilya Y. Ilyin

IPC分类号： G06Q10/00 ,  G06N5/02 ,  G06Q50/00

CPC分类号： G06Q50/04 ,  G06Q10/06 ,  G06Q30/0206 ,  Y02P90/30

摘要： Flour may be treated to denature the proteins and modify starches. The invention includes methods and systems for determining whether to use treated flour or untreated flour. The invention also includes methods and systems for determining whether to treat flour or not.

摘要翻译： 可以对面粉进行处理以使蛋白质变性并改性淀粉。 本发明包括用于确定是否使用经处理的面粉或未处理的面粉的方法和系统。 本发明还包括用于确定是否处理面粉的方法和系统。

公开(公告)号：US10098340B2

公开(公告)日：2018-10-16

申请号：US13982766

申请日：2012-02-03

申请人： William E. Grieshober, Jr. ,  James S. Jones ,  Semyon Kogan ,  Ilya Ilyin ,  Natella I. Enukashvily ,  Yana A. Filkina ,  Alexander N. Shumeev ,  Stanislav Kolchanov

发明人： William E. Grieshober, Jr. ,  James S. Jones ,  Semyon Kogan ,  Ilya Ilyin ,  Natella I. Enukashvily ,  Yana A. Filkina ,  Alexander N. Shumeev ,  Stanislav Kolchanov

IPC分类号： A01N1/02

摘要： Provided is a method for reducing apoptosis in nucleated cells. The method entails holding nucleated cells in a container and adding a gas containing xenon to the container so that the pressure inside the container reaches between 0.5 to 4.0 Atm above ambient pressure; holding the container at between 0.5 to 4.0 Atm above ambient pressure for a period of time during which the temperature in the container is between 22° C. and 37° C.; lowering the temperature in the container to between 0.1° C. and 10° C. while maintaining the pressure of 0.5 to 4.0 Atm above ambient pressure and holding the container for a period of time; and reducing the pressure in the container to ambient pressure and increasing the temperature to 22° C.-37° C. By performing these steps, the cells undergo less apoptosis than a reference.

公开(公告)号：US20120301582A1

公开(公告)日：2012-11-29

申请号：US13567164

申请日：2012-08-06

申请人： Praveen Upreti ,  Rohit Jalali ,  William E. Grieshober, JR. ,  John S. Roberts ,  Melissa D. Haller ,  Michael Fuchs ,  Ilya Y. Ilyin

发明人： Praveen Upreti ,  Rohit Jalali ,  William E. Grieshober, JR. ,  John S. Roberts ,  Melissa D. Haller ,  Michael Fuchs ,  Ilya Y. Ilyin

IPC分类号： G01N33/10 ,  A21D6/00

CPC分类号： G06Q50/04 ,  G06Q10/06 ,  G06Q30/0206 ,  Y02P90/30

摘要： Flour may be treated to denature the proteins and modify starches. The invention includes methods and systems for determining whether to use treated flour or untreated flour. The invention also includes methods and systems for determining whether to treat flour or not.

摘要翻译： 可以对面粉进行处理以使蛋白质变性并改性淀粉。 本发明包括用于确定是否使用经处理的面粉或未处理的面粉的方法和系统。 本发明还包括用于确定是否处理面粉的方法和系统。

公开(公告)号：US20120298691A1

公开(公告)日：2012-11-29

申请号：US13565218

申请日：2012-08-02

申请人： Rohit Jalali ,  Christopher Vincent Tirone ,  Theodore Watson Rich ,  Steven A. Franz ,  William E. Grieshober, JR. ,  Joseph Victor Bisacca ,  Lisa Augustine ,  Kerry Marshal Chace ,  Timothy A. Falken ,  David E. Moomaw

发明人： Rohit Jalali ,  Christopher Vincent Tirone ,  Theodore Watson Rich ,  Steven A. Franz ,  William E. Grieshober, JR. ,  Joseph Victor Bisacca ,  Lisa Augustine ,  Kerry Marshal Chace ,  Timothy A. Falken ,  David E. Moomaw

IPC分类号： B65D83/76 ,  B65D35/30

CPC分类号： B05C17/0123 ,  A23G3/28 ,  B05C17/00583 ,  B05C17/0109

摘要： A dispensing device having a housing capable of receiving a pre-packaged charge of pre-whipped topping or icing. The housing has an inner wall with a slot formed therein for receiving a rack that is capable of rotational and translational motion within the slot. The rack has a set of gear teeth that engage with a catch on a plunger. The piston moves in the axial direction to force the pre-whipped topping or icing through the outlet in its packaging. The catch on the piston is locked in one direction and pivots in the opposite direction such that the rack engages with the piston when it moves in a first direction and the rack disengages with the piston when it is moved in a second direction opposite the first direction.

摘要翻译： 一种分配装置，其具有能够接收预先打包的顶部或结冰的预包装的容器的壳体。 壳体具有形成在其中的狭槽的内壁，用于容纳能够在槽内旋转和平移运动的齿条。 齿条具有与柱塞上的卡扣啮合的一组齿轮齿。 活塞在轴向方向上移动，以迫使预先鞭打的顶部或结冰通过其包装中的出口。 活塞上的卡扣在一个方向上被锁定并且沿相反方向枢转，使得当齿条沿着第一方向移动时齿条与活塞接合，并且当齿条沿着与第一方向相反的第二方向移动时，齿条与活塞脱离 。

公开(公告)号：US20130157249A1

公开(公告)日：2013-06-20

申请号：US13529024

申请日：2012-06-21

申请人： Ilya Ilyin ,  Semyon Kogan ,  William E. Grieshober, JR. ,  Igor Kachko ,  Vladimir Vasiliev ,  Stanislav A. Kolchanov ,  Yuriy Punin ,  Mark Bakhrakh ,  Alexander N. Shumeev

发明人： Ilya Ilyin ,  Semyon Kogan ,  William E. Grieshober, JR. ,  Igor Kachko ,  Vladimir Vasiliev ,  Stanislav A. Kolchanov ,  Yuriy Punin ,  Mark Bakhrakh ,  Alexander N. Shumeev

IPC分类号： A01N1/02

CPC分类号： A01N1/021 ,  A01N1/0242 ,  A01N1/0263 ,  A01N1/0289 ,  A61J1/10 ,  A61J1/16

摘要： A system, method, and device for preserving blood and its components is described. The system and method generally include a device having a body defining a chamber, the chamber being configured to receive at least one bag containing blood or its components, the at least one bag being permeable to gas, for example, xenon. A cover is hermetically sealable to the body. An inlet is in fluid communication with the chamber. A pressure indicator is configured to indicate pressure in the chamber, the pressure indicator including a conduit containing a liquid. A portion of the conduit is transparent such that the liquid is visible. A source of pressurized gas, such as xenon, is provided to provide the pressurized gas to the chamber.

摘要翻译： 描述了一种用于保存血液及其组分的系统，方法和装置。 该系统和方法通常包括具有限定腔室的主体的装置，所述腔室构造成容纳至少一个含有血液或其组分的袋，所述至少一个袋子可渗透气体，例如氙气。 盖子对身体密封。 入口与腔室流体连通。 压力指示器构造成指示腔室中的压力，压力指示器包括含有液体的导管。 导管的一部分是透明的，使得液体是可见的。 提供诸如氙气的加压气体源，以将加压气体提供给腔室。

公开(公告)号：US08297481B2

公开(公告)日：2012-10-30

申请号：US11388592

申请日：2006-03-24

申请人： Rohit Jalali ,  Christopher Vincent Tirone ,  Theodore Watson Rich ,  Steven A. Franz ,  William E. Grieshober, Jr. ,  Joseph Victor Bisacca ,  Lisa Augustine ,  Kerry Marshal Chace ,  Timothy A. Falken ,  David E. Moomaw

发明人： Rohit Jalali ,  Christopher Vincent Tirone ,  Theodore Watson Rich ,  Steven A. Franz ,  William E. Grieshober, Jr. ,  Joseph Victor Bisacca ,  Lisa Augustine ,  Kerry Marshal Chace ,  Timothy A. Falken ,  David E. Moomaw

IPC分类号： B67D7/64

CPC分类号： B05C17/0123 ,  A23G3/28 ,  B05C17/00583 ,  B05C17/0109

摘要： A dispensing device having a housing capable of receiving a pre-packaged charge of pre-whipped topping or icing. The housing has an inner wall with a slot formed therein for receiving a rack that is capable of rotational and translational motion within the slot. The rack has a set of gear teeth that engage with a catch on a plunger. The piston moves in the axial direction to force the pre-whipped topping or icing through the outlet in its packaging. The catch on the piston is locked in one direction and pivots in the opposite direction such that the rack engages with the piston when it moves in a first direction and the rack disengages with the piston when it is moved in a second direction opposite the first direction.

摘要翻译： 一种分配装置，其具有能够接收预先打包的顶部或结冰的预包装的容器的壳体。 壳体具有形成在其中的狭槽的内壁，用于容纳能够在槽内旋转和平移运动的齿条。 齿条具有与柱塞上的卡扣啮合的一组齿轮齿。 活塞在轴向方向上移动，以迫使预先鞭打的顶部或结冰通过其包装中的出口。 活塞上的卡扣在一个方向上被锁定并且沿相反方向枢转，使得当齿条沿着第一方向移动时齿条与活塞接合，并且当齿条沿着与第一方向相反的第二方向移动时，齿条与活塞脱离 。