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公开(公告)号：US20200078439A1
公开(公告)日：2020-03-12
申请号：US16510442
申请日：2019-07-12
Applicant: Immatics Biotechnologies GmbH
Inventor： Hans Georg RAMMENSEE , Stefan STEVANOVIC , Cecile GOUTTEFANGEAS , Toni WEINSCHENK , Peter LEWANDROWSKI
Abstract: The present invention relates to peptides, nucleic acids, and cells for use in the immunotherapy of cancer. The present invention furthermore relates to survivin-derived tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention specifically relates to three novel peptide sequences and variants thereof derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
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公开(公告)号：US20150044246A1
公开(公告)日：2015-02-12
申请号：US14503690
申请日：2014-10-01
Applicant: immatics biotechnologies GmbH
Inventor： Toni WEINSCHENK , Hans Georg RAMMENSEE
CPC classification number: C12Q1/6876 , A61K38/04 , A61K39/00 , A61K2039/55 , A61K2039/572 , C07K7/00 , C07K14/4748 , C12Q1/6837 , C12Q2600/136 , C12Q2600/158 , G01N33/50 , G01N33/53 , G01N33/574 , G01N33/57484 , G01N33/68
Abstract: The invention relates to a method for identifying immunoreactive peptides. According to said method, a sample of tumorous and corresponding healthy tissue is first provided, the tumor-specific expression profile is subsequently determined and antigenic peptides are isolated from the tumorous tissue and analyzed. The respective data that has been obtained is then matched and peptides are identified on the basis of said data.
Abstract translation: 本发明涉及鉴定免疫反应肽的方法。 根据所述方法，首先提供肿瘤和相应的健康组织的样品，随后确定肿瘤特异性表达谱，并从肿瘤组织中分离抗原肽。 然后将所获得的相应数据进行匹配，并且基于所述数据识别肽。
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公开(公告)号：US20130251751A1
公开(公告)日：2013-09-26
申请号：US13775095
申请日：2013-02-22
Applicant: IMMATICS BIOTECHNOLOGIES GMBH
Inventor： Toni WEINSCHENK , Hans Georg RAMMENSEE
IPC: C12Q1/68
CPC classification number: C12Q1/6876 , A61K38/04 , A61K39/00 , A61K2039/55 , A61K2039/572 , C07K7/00 , C07K14/4748 , C12Q1/6837 , C12Q2600/136 , C12Q2600/158 , G01N33/50 , G01N33/53 , G01N33/574 , G01N33/57484 , G01N33/68
Abstract: The invention relates to a method for identifying immunoreactive peptides. According to said method, a sample of tumorous and corresponding healthy tissue is first provided, the tumor-specific expression profile is subsequently determined and antigenic peptides are isolated from the tumorous tissue and analyzed. The respective data that has been obtained is then matched and peptides are identified on the basis of said data.
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