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1.
公开(公告)号:US11690872B2
公开(公告)日:2023-07-04
申请号:US16200308
申请日:2018-11-26
Applicant: Immatics US, Inc.
Inventor: Monique Dao , Steffen Walter , Melinda Mata , Aleksandra Nowicka , Yannick Bulliard , Sarah Missell , Sabrina Kuttruff-Coqui , Norbert Hilf
IPC: A61K35/17 , C12N5/0783 , A61K31/663 , A61K31/675 , A61K38/20 , C07K14/54 , C07K14/55 , C12N5/00 , C12N15/62 , C12N15/85 , A61K35/12 , C07K16/28
CPC classification number: A61K35/17 , A61K31/663 , A61K31/675 , A61K38/2013 , C07K14/5443 , C07K14/55 , C12N5/0018 , C12N5/0636 , C12N5/0638 , C12N15/62 , C12N15/8509 , A61K2035/122 , A61K2035/124 , C07K16/2809 , C12N2501/155 , C12N2501/2302 , C12N2501/2315 , C12N2501/515 , C12N2501/998 , C12N2740/10043
Abstract: The present disclosure relates to expansion and activation of T cells. In an aspect, the present disclosure relates to expansion and activation of γδ T cells that may be used for transgene expression. In another aspect, the disclosure relates to expansion and activation of γδ T cells while depleting α- and/or β-TCR positive cells. T cell populations comprising expanded γδ T cell and depleted or reduced α- and/or β-TCR positive cells are also provided for by the instant disclosure. The disclosure further provides for methods of using the disclosed T cell populations.
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2.
公开(公告)号:US20190175650A1
公开(公告)日:2019-06-13
申请号:US16200308
申请日:2018-11-26
Applicant: Immatics US, Inc.
Inventor: Monique Dao , Steffen Walter , Melinda Mata , Aleksandra Nowicka , Yannick Bulliard
IPC: A61K35/17 , C12N5/0783 , C12N5/00 , C12N15/62 , A61K31/675 , A61K38/20 , C07K14/55 , C07K14/54 , C07K16/28 , A61K31/663 , C12N15/85
Abstract: The present disclosure relates to expansion and activation of T cells. In an aspect, the present disclosure relates to expansion and activation of γδ T cells that may be used for transgene expression. In another aspect, the disclosure relates to expansion and activation of γδ T cells while depleting α- and/or β-TCR positive cells. T cell populations comprising expanded γδ T cell and depleted or reduced α- and/or β-TCR positive cells are also provided for by the instant disclosure. The disclosure further provides for methods of using the disclosed T cell populations.
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