公开(公告)号：US20210139485A1

公开(公告)日：2021-05-13

申请号：US17077713

申请日：2020-10-22

申请人： Incyte Corporation

发明人： Xiaozhao Wang ,  Pei Gan ,  Heeoon Han ,  Taisheng Huang ,  Matthew S. McCammant ,  Chao Qi ,  Ding-Quan Qian ,  Liangxing Wu ,  Wenqing Yao ,  Zhiyong Yu ,  Fenglei Zhang

IPC分类号： C07D487/04 ,  C07D491/056 ,  C07D519/00 ,  A61P35/00 ,  A61P25/00 ,  A61P9/00 ,  A61P29/00

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which modulate the activity of adenosine receptors, such as subtypes A2A and A2B receptors, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US11168089B2

公开(公告)日：2021-11-09

申请号：US16415610

申请日：2019-05-17

申请人： Incyte Corporation

发明人： Xiaozhao Wang ,  Heeoon Han ,  Matthew S. McCammant ,  Liangxing Wu ,  Wenqing Yao ,  Zhiyong Yu ,  Le Zhao

IPC分类号： C07D487/04 ,  C07D519/00

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which modulate the activity of adenosine receptors, such as subtypes A2A and A2B receptors, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US20210269434A1

公开(公告)日：2021-09-02

申请号：US17144374

申请日：2021-01-08

申请人： Incyte Corporation

发明人： Xiaozhao Wang ,  Wenyu Zhu ,  Jeffrey Yang ,  Alexander Sokolsky ,  Chunhong He ,  Zhenwu Li ,  Chao Qi ,  Yong Li ,  Pei Gan ,  Peter Carlsen ,  Gia Hoang ,  Heeoon Han ,  Chenyin Marshall Law ,  Fenglei Zhang ,  Padmaja Polam ,  Le Zhao ,  Liangxing Wu ,  Wenqing Yao

IPC分类号： C07D471/04 ,  A61P35/00 ,  C07D519/00 ,  C07D471/14

摘要： Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

公开(公告)号：US20210061809A1

公开(公告)日：2021-03-04

申请号：US17002045

申请日：2020-08-25

申请人： Incyte Corporation

发明人： Heeoon Han ,  Le Zhao ,  Wenqing Yao ,  Xiaozhao Wang

IPC分类号： C07D487/04

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which modulate the activity of adenosine receptors, such as subtypes A2A and A2B receptors, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US11873304B2

公开(公告)日：2024-01-16

申请号：US17159345

申请日：2021-01-27

申请人： Incyte Corporation

发明人： Xiaozhao Wang ,  Heeoon Han ,  Matthew S. McCammant ,  Liangxing Wu ,  Wenqing Yao ,  Zhiyong Yu ,  Le Zhao

IPC分类号： A61P35/00 ,  A61P35/04 ,  A61K31/519 ,  C07D487/04 ,  C07D519/00

CPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/00 ,  A61P35/04 ,  C07D519/00

摘要： This application relates to compounds of Formula (I):




or pharmaceutically acceptable salts thereof, which modulate the activity of adenosine receptors, such as subtypes A2A and A2B receptors, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US20230124485A1

公开(公告)日：2023-04-20

申请号：US18077610

申请日：2022-12-08

申请人： Incyte Corporation

发明人： Heeoon Han ,  Le Zhao ,  Wenqing Yao ,  Xiaozhao Wang

IPC分类号： C07D487/04

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which modulate the activity of adenosine receptors, such as subtypes A2A and A2B receptors, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US20210261555A1

公开(公告)日：2021-08-26

申请号：US17159345

申请日：2021-01-27

申请人： Incyte Corporation

发明人： Xiaozhao Wang ,  Heeoon Han ,  Matthew S. McCammant ,  Liangxing Wu ,  Wenqing Yao ,  Zhiyong Yu ,  Le Zhao

IPC分类号： C07D487/04 ,  C07D519/00

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which modulate the activity of adenosine receptors, such as subtypes A2A and A2B receptors, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US20190292188A1

公开(公告)日：2019-09-26

申请号：US16285787

申请日：2019-02-26

申请人： Incyte Corporation

发明人： Xiaozhao Wang ,  Pei Gan ,  Heeoon Han ,  Taisheng Huang ,  Matthew S. McCammant ,  Chao Qi ,  Ding-Quan Qian ,  Liangxing Wu ,  Wenqing Yao ,  Zhiyong Yu ,  Fenglei Zhang

IPC分类号： C07D487/04 ,  C07D491/056 ,  C07D519/00

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which modulate the activity of adenosine receptors, such as subtypes A2A and A2B receptors, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases.