公开(公告)号：US20190388477A1

公开(公告)日：2019-12-26

申请号：US16311633

申请日：2018-02-21

Applicant: Indiana University Research and Technology Corporation

Inventor： Mervin C. Yoder ,  David P. Basile

IPC: A61K35/44 ,  C12N5/071 ,  A61K45/06 ,  A61P9/10 ,  A61P13/12

Abstract: The present disclosure provides compositions and methods for the treatment or prophylaxis of a perfusion disorder, such as ischemia and/or reperfusion injury, in a subject's organ, tissue or extremity by preserving or improving endothelial function, reducing vascular injury, and/or promoting vascular repair. The disclosed compositions comprise endothelial colony-forming cells or a serum-free composition comprising chemically defined media conditioned by endothelial colony-forming cells.