公开(公告)号：US09458220B2

公开(公告)日：2016-10-04

申请号：US14563362

申请日：2014-12-08

Applicant: Indiana University Research and Technology Corporation

Inventor： Richard D. DiMarchi ,  Yulia Azriel ,  Zachary Kaur ,  Jonathan Meyers ,  Todd Parody ,  Yan Zhao

IPC: C07K14/62 ,  A61K38/28 ,  A61K47/48 ,  A61K38/00

CPC classification number: C07K14/62 ,  A61K38/00 ,  A61K38/18 ,  A61K38/28 ,  A61K47/60 ,  C07K14/475

Abstract: Single chain insulin analogs are provided having high potency and specificity for the insulin receptor. As disclosed herein optimally sized linking moieties can be used to link human insulin A and B chains, or analogs or derivatives thereof, wherein the carboxy terminus of the B25 amino acid of the B chain is linked to the amino terminus of the A1 amino acid of the A chain via the intervening linking moiety. In on embodiment the linking moiety comprises a polyethylene glycol of 6-16 monomer units and in an alternative embodiment the linking moiety comprises a non-native amino acid sequence derived form the IGF-1 C-peptide and comprising at least 8 amino acids and no more than 12 amino acid in length. Also disclosed are prodrug and conjugate derivatives of the single chain insulin analogs.

公开(公告)号：US10233225B2

公开(公告)日：2019-03-19

申请号：US15229942

申请日：2016-08-05

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： Richard D. DiMarchi ,  Yulia Azriel ,  Zachary Kaur ,  Jonathan Meyers ,  Todd Parody ,  Yan Zhao

IPC: A61K38/00 ,  A61K38/18 ,  A61K38/28 ,  C07K14/62 ,  C07K14/475 ,  A61K47/60

Abstract: Single chain insulin analogs are provided having high potency and specificity for the insulin receptor. As disclosed herein optimally sized linking moieties can be used to link human insulin A and B chains, or analogs or derivatives thereof, wherein the carboxy terminus of the B25 amino acid of the B chain is linked to the amino terminus of the A1 amino acid of the A chain via the intervening linking moiety. In on embodiment the linking moiety comprises a polyethylene glycol of 6-16 monomer units and in an alternative embodiment the linking moiety comprises a non-native amino acid sequence derived form the IGF-1 C-peptide and comprising at least 8 amino acids and no more than 12 amino acid in length. Also disclosed are prodrug and conjugate derivatives of the single chain insulin analogs.