公开(公告)号：US10828337B2

公开(公告)日：2020-11-10

申请号：US15891252

申请日：2018-02-07

Applicant: Indiana University Research and Technology Corporation

Inventor： Mervin C. Yoder ,  Paul Critser ,  Sherry Voytik-Harbin

IPC: A61K35/51 ,  A61K9/70 ,  A61L27/24 ,  A61L27/38

Abstract: Materials and methods are disclosed for controlling vasculogenesis using building blocks of a collagen matrix and endothelial colony forming cells (ECFC). The building blocks may be isolated by fractionating an acid soluble Type I collagen. The building blocks comprising monomers and/or oligomers may be recombined in desired ratios to alter the matrix microenvironment and to influence ECFC behavior.

公开(公告)号：US20190000891A1

公开(公告)日：2019-01-03

申请号：US15891252

申请日：2018-02-07

Applicant: Indiana University Research and Technology Corporation

Inventor： Mervin C. Yoder ,  Paul Critser ,  Sherry Voytik-Harbin

IPC: A61K35/51 ,  A61L27/24 ,  A61L27/38 ,  A61K9/70

CPC classification number: A61K35/51 ,  A61K9/70 ,  A61L27/24 ,  A61L27/3808

Abstract: Materials and methods are disclosed for controlling vasculogenesis using building blocks of a collagen matrix and endothelial colony forming cells (ECFC). The building blocks may be isolated by fractionating an acid soluble Type I collagen. The building blocks comprising monomers and/or oligomers may be recombined in desired ratios to alter the matrix microenvironment and to influence ECFC behavior.