公开(公告)号：US12121631B2

公开(公告)日：2024-10-22

申请号：US17527679

申请日：2021-11-16

Applicant: Muffin Incorporated ,  Cook Biotech Incorporated

Inventor： Michael C. Hiles ,  Chad E. Johnson ,  Neal E. Fearnot ,  Thomas Payne ,  Ronald Jankowski

IPC: A61L27/50 ,  A61L27/24 ,  A61L27/36 ,  A61L27/38 ,  C12M1/00 ,  C12M1/12 ,  C12M3/00 ,  C12N5/00

CPC classification number: A61L27/50 ,  A61L27/24 ,  A61L27/3604 ,  A61L27/3633 ,  A61L27/3808 ,  A61L27/3826 ,  C12M21/08 ,  C12M23/06 ,  C12M23/34 ,  C12M25/14 ,  C12N5/0062 ,  A61L2430/02 ,  A61L2430/06 ,  A61L2430/26 ,  A61L2430/28 ,  A61L2430/30 ,  A61L2430/32 ,  A61L2430/34 ,  C12N2533/54

Abstract: Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.

公开(公告)号：US20240301361A1

公开(公告)日：2024-09-12

申请号：US18670347

申请日：2024-05-21

Applicant: Public University Corporation Yokohama City University

Inventor： Hideki TANIGUCHI ,  Takanori TAKEBE

IPC: C12N5/071 ,  A01K67/0271 ,  A61L27/38

CPC classification number: C12N5/0697 ,  A01K67/0271 ,  A61L27/3808 ,  A61L27/3834 ,  A61L27/3839 ,  A61L27/3886 ,  A01K2207/12 ,  A61L2430/28 ,  C12N2506/45

Abstract: The present disclosure relates to an organ bud and a method of preparing an organ bud.

公开(公告)号：US20240216579A1

公开(公告)日：2024-07-04

申请号：US18558837

申请日：2022-05-13

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Joshua Honghan Hou ,  Peter Bedard ,  Chun Wang ,  Ching Yuan ,  Sung Lee ,  Aaron Bae

IPC: A61L27/36 ,  A61F2/14 ,  A61L27/34 ,  A61L27/38 ,  A61L27/54

CPC classification number: A61L27/3604 ,  A61F2/142 ,  A61F2/148 ,  A61L27/34 ,  A61L27/3641 ,  A61L27/3808 ,  A61L27/3839 ,  A61L27/54 ,  A61L2300/404 ,  A61L2400/06 ,  A61L2400/10 ,  A61L2400/12 ,  A61L2420/02 ,  A61L2420/06 ,  A61L2430/16

Abstract: A graft injector assembly includes a coating disposed on an interior surface of an injector body to form a lumen. The lumen is structured to store a graft comprising corneal tissue and to allow the graft to exit distally from the injector body, preferably with minimal or no damage to the corneal tissue. The corneal tissue may include a Descemet membrane and endothelial cells, which may be used in Descemet Membrane Endothelial Keratoplasty (DMEK). In one example, the assembly includes an organosilane coating disposed on a glass injector body.

公开(公告)号：US11890395B2

公开(公告)日：2024-02-06

申请号：US16010120

申请日：2018-06-15

Applicant: Avery Therapeutics, Inc.

Inventor： Jordan J. Lancaster ,  Steven Goldman ,  Jennifer Watson Koevary

IPC: A61L27/36 ,  A61L27/38 ,  A61L27/58 ,  A61L27/56 ,  A61L27/22 ,  A61L27/34

CPC classification number: A61L27/3633 ,  A61L27/22 ,  A61L27/34 ,  A61L27/3691 ,  A61L27/383 ,  A61L27/3804 ,  A61L27/3808 ,  A61L27/3821 ,  A61L27/3826 ,  A61L27/3834 ,  A61L27/56 ,  A61L27/58 ,  A61L27/367 ,  A61L27/3873 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2300/64 ,  A61L2420/00 ,  A61L2430/20 ,  A61L2430/40

Abstract: Engineered tissue compositions for supporting cell growth, maintenance, and/or differentiation featuring a scaffold, extracellular matrix (ECM) material, and optionally a population of ECM-generating cells such as fibroblasts. The tissue compositions may be used for supporting seeded cells of a particular cell type of interest such as cells related to skeletal muscle, smooth muscle, cardiac tissue, gastrointestinal tissue, etc. The tissue compositions with seeded cells may develop into functional tissues, which may have the potential to provide a tissue graft for therapeutic purposes or a valuable model for in vitro assays.

公开(公告)号：US11771807B2

公开(公告)日：2023-10-03

申请号：US16515946

申请日：2019-07-18

Applicant: The Johns Hopkins University

Inventor： Sashank Reddy ,  Russell Martin ,  Xiaowei Li ,  Calvin Chang ,  Kevin Colbert ,  Hai-Quan Mao

IPC: A61L27/58 ,  A61L27/54 ,  A61L27/20 ,  A61L27/18 ,  A61L27/44 ,  A61L27/38 ,  A61L27/52 ,  A61M5/19 ,  A61L27/48 ,  A61L27/56 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

CPC classification number: A61L27/58 ,  A61L27/18 ,  A61L27/20 ,  A61L27/3808 ,  A61L27/3834 ,  A61L27/3895 ,  A61L27/44 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61M5/19 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/602 ,  A61L2300/604 ,  A61L2300/622 ,  A61L2400/06 ,  A61L2400/12 ,  A61L2430/34 ,  A61M2202/08 ,  A61M2202/09 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

Abstract: A soft tissue device can incorporate a composite material comprising a gel and at least one nanostructure disposed within the gel. A soft tissue device can further incorporate biologically active materials such as cells, tissues. A method for healing a soft tissue defect while promoting soft tissue regeneration can include applying a soft tissue device to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a soft tissue device for use in healing soft tissue defects can include providing a gel, disposing nanofibers within the gel, and a biologically active material.

公开(公告)号：US20230301790A1

公开(公告)日：2023-09-28

申请号：US18190374

申请日：2023-03-27

Applicant: MOC BIO TECHNOLOGIES INC.

Inventor： Sayedali Mousavi

IPC: A61F2/30 ,  A61L27/38

CPC classification number: A61F2/3094 ,  A61L27/3826 ,  A61L27/3808 ,  A61F2002/30985

Abstract: A smart adjustable platform for a bioprinter is described. The adjustable platform comprises: a housing having an upper surface with a support region for providing support for 4D printing of a biomaterial; and at least one stimulator that is mounted within the housing, the at least one stimulator being configured to provide one or more stimuli to the biomaterial during printing and/or after printing for effecting a change in characteristic of the biomaterial including structure and/or morphology, wherein the at least one stimulator comprises a mechanical stimulator and/or an electromagnetic stimulator.

公开(公告)号：US20230201423A1

公开(公告)日：2023-06-29

申请号：US18116472

申请日：2023-03-02

Applicant: NATIONAL DEFENSE MEDICAL CENTER

Inventor： Chung-Hsing CHOU ,  Dueng-Yuan Hueng ,  Tsung-Neng TSAI

IPC: A61L27/38 ,  A61L27/36 ,  A61L27/24 ,  C12N5/071 ,  A61K35/30 ,  C12N5/079 ,  A61K35/44

CPC classification number: A61L27/3891 ,  A61L27/3633 ,  A61L27/383 ,  A61L27/3808 ,  A61L27/3878 ,  A61L27/3675 ,  A61L27/24 ,  C12N5/0697 ,  A61K35/30 ,  C12N5/0618 ,  A61K35/44 ,  A61L2430/32 ,  C12N2502/28 ,  C12N2502/088 ,  C12N2533/54 ,  C12N2500/25 ,  C12N2500/46 ,  C12N2501/392 ,  C12N2501/11 ,  C12N2501/115

Abstract: The invention relates to a cell sheet construct for neurovascular reconstruction. The cell sheet construct has a vascular endothelial cell layer and a neural stem cell layer, and the two layers are physically in direct contact with each other, where the vascular endothelial cell layer forms branching vasculatures, and the neural stem cell layer differentiates into neurons. The invention also relates to a method for manufacturing the cell sheet construct, having the following steps: culturing vascular endothelial cells on a substrate to form a vascular endothelial cell layer, seeding neural stem cells on the vascular endothelial cell layer to make the neural stem cells be physically in direct contact with the vascular endothelial cell layer, and culturing the neural stem cells and the vascular endothelial cell layer to differentiate into neurons and branching vasculatures to form a cell sheet construct.

公开(公告)号：US20190192271A1

公开(公告)日：2019-06-27

申请号：US16288790

申请日：2019-02-28

Applicant: National University Corporation Tokyo Medical and Dental University ,  DAI NIPPON PRINTING CO., LTD.

Inventor： Ikuo MORITA ,  Akiko KOBAYASHI ,  Hideshi HATTORI ,  Masatoshi KURODA

IPC: A61F2/02 ,  A61L27/38 ,  A61L27/36 ,  A61L27/58 ,  B82Y30/00 ,  C12N5/00 ,  C12N5/071

CPC classification number: A61F2/02 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/0067 ,  A61K35/12 ,  A61L27/3604 ,  A61L27/3804 ,  A61L27/3808 ,  A61L27/3843 ,  A61L27/58 ,  A61L2430/12 ,  A61L2430/34 ,  B82Y30/00 ,  C12N5/0068 ,  C12N5/069 ,  C12N2533/92 ,  C12N2535/10

Abstract: In accordance with the present invention, an implant in which cells are arranged in a fine pattern that is available for immediate implantation and that does not need to be removed after implantation is provided. The present invention relates to a cell-containing sheet, which comprises cells and a support comprising a bioabsorbable material, in which the support has a cell adhesion protein-containing layer on the surface thereof and the cells form a pattern on the support.

公开(公告)号：US20180304502A1

公开(公告)日：2018-10-25

申请号：US15768161

申请日：2016-10-14

Applicant: Juan Pablo ACEVEDO ,  Camila WILKENS ,  Maroun KHOURY ,  Christopher RIVET ,  UNIVERSIDAD DE LOS ANDES ,  CELLS FOR CELLS, S.P.A

Inventor： Juan Pablo ACEVEDO ,  Camila WILKENS ,  Maroun KHOURY ,  Christopher RIVET

IPC: B29C41/22 ,  B32B1/08 ,  B32B9/02 ,  B29C41/14 ,  A61L27/22 ,  A61L27/54 ,  A61L27/38 ,  A61L27/34 ,  A61L27/18 ,  A61L27/26 ,  A61L27/58 ,  A61L27/50 ,  A61L27/36 ,  A61L27/20 ,  A61F2/04 ,  A61F2/06

CPC classification number: B29C41/22 ,  A61F2/04 ,  A61F2/06 ,  A61F2002/047 ,  A61F2210/0076 ,  A61F2240/001 ,  A61L27/18 ,  A61L27/20 ,  A61L27/222 ,  A61L27/26 ,  A61L27/34 ,  A61L27/3679 ,  A61L27/3808 ,  A61L27/3813 ,  A61L27/3817 ,  A61L27/3826 ,  A61L27/3834 ,  A61L27/3882 ,  A61L27/507 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/604 ,  A61L2300/608 ,  A61L2300/64 ,  A61L2420/02 ,  A61L2420/08 ,  A61L2430/22 ,  A61L2430/32 ,  B29C41/14 ,  B29K2089/00 ,  B29L2031/7534 ,  B32B1/08 ,  B32B9/02 ,  B32B2535/00 ,  C08L67/04 ,  C08L89/06

Abstract: The present invention overcomes all the above drawbacks and provides a versatile method for the fabrication of multilayer hollow tubes that uses a layer-by-layer rod dipping approach using different biomaterials. The device enables fine control over fabrication parameters, such as ascending/descending speeds, rod rotational velocity, and crosslinking or polymerization time. All these technologies allows the generation of more complex multilayer hollow tubes such as vessel-like structures, urethral grafting, prostate grafting and the like.

公开(公告)号：US20180272136A1

公开(公告)日：2018-09-27

申请号：US15993497

申请日：2018-05-30

Applicant: Cook Biotech Incorporated ,  Cook Medical Technologies LLC

Inventor： Joseph B. Horn ,  Michael C. Hiles

IPC: A61N1/375 ,  A61L27/58 ,  A61L27/38 ,  A61L27/36 ,  A61L27/54 ,  A61N1/362

CPC classification number: A61N1/375 ,  A61L27/3633 ,  A61L27/3808 ,  A61L27/54 ,  A61L27/58 ,  A61L2430/20 ,  A61N1/362

Abstract: Certain aspects of this disclosure relate to uniquely constructed medical implants that incorporate an electronic or other medical device. Some illustrative pocket-like implants provide an interior space for receipt of an electronic medical device, and are implantable in a patient with the electronic medical device positioned in the interior space. In one form, an inventive construct includes a remodelable material component that is effective upon implantation to promote cellular invasion and ingrowth into the remodelable material so that it becomes replaced by new patient tissue and so that the electronic medical device becomes surrounded by a new pocket structure comprised of newly generated, functional patient tissue. The electronic medical device will be a pacing device or other cardiac rhythm management (CRM) device in select embodiments.