公开(公告)号：US20180169262A1

公开(公告)日：2018-06-21

申请号：US15830272

申请日：2017-12-04

Applicant: Industrial Technology Research Institute

Inventor： Maggie Lu ,  May-Hua Chang ,  Jenn-Tsang Hwang ,  Ping-Fu Cheng ,  Li-Wen Chang ,  Yi-Ju Ko ,  Chi-Y Hung ,  Chun-Min Liu ,  Chia-Yu Fan

IPC: A61K47/68 ,  A61K31/4745 ,  A61K47/64 ,  C07K16/30

CPC classification number: A61K47/6889 ,  A61K31/4745 ,  A61K47/64 ,  A61K47/65 ,  A61K47/6803 ,  A61K47/6817 ,  A61K47/6851 ,  A61K47/6855 ,  A61P35/00 ,  C07K16/30

Abstract: A linker-drug represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. In formula (I), C is a conjugator, L is a linker unit, D is a toxin unit, and n is an integer ranging from 1 to 4. The structure of the conjugator is represented by formula (II). In formula (II), X is a leaving group, each of R1 and R2 is independently a single bond or —NH—, and Z is substituted aryl, heteroaryl, linear alkyl, cycloalkyl, heterocycloalkyl, or a combination thereof. The antibody is conjugated to the linker unit through a cysteine residue of the antibody. An antibody-drug conjugate (ADC) employing the above linker-drug is also provided.

公开(公告)号：US20240189243A1

公开(公告)日：2024-06-13

申请号：US18507536

申请日：2023-11-13

Applicant: Industrial Technology Research Institute

Inventor： Felice Cheng ,  Ping-Fu Cheng ,  Jenn-Tsang Hwang ,  Chih-Wei Fu ,  Ku-Feng Lin ,  Ya-Ling Chiu ,  Jheng-Sian Li ,  Kang-Li Wang ,  Siou-Han Chang ,  Chia-Yu Fan

IPC: A61K9/51 ,  A61K31/7105 ,  A61K31/711 ,  A61K47/28 ,  C07F9/09 ,  C07F9/535 ,  C07F9/6509 ,  C07F9/6512

CPC classification number: A61K9/5123 ,  A61K31/7105 ,  A61K31/711 ,  A61K47/28 ,  C07F9/091 ,  C07F9/535 ,  C07F9/650952 ,  C07F9/6512

Abstract: A lipid compound or a derivative thereof and a pharmaceutical composition employing the same are provided. The lipid compound has a structure represented by Formula (I):






wherein Z1, Z2, Z3 and Z4 are as disclosed in the specification.

公开(公告)号：US10604586B2

公开(公告)日：2020-03-31

申请号：US15589191

申请日：2017-05-08

Applicant: Industrial Technology Research Institute

Inventor： Chia-Yu Fan ,  Min-Yuan Chou

IPC: C07K16/28 ,  A61K39/44 ,  A61K39/395 ,  A61K47/69 ,  A61K47/68 ,  C07K16/46 ,  C07K16/18 ,  C07K19/00 ,  A61K39/00

Abstract: A humanized monoclonal antibody against the CD34 surface antigen is provided in the present disclosure. The humanized monoclonal antibody includes a light chain variable region and a heavy chain variable region. In which, a nucleotide sequence encoding the amino acid sequence for the light chain variable region comprises a nucleotide sequence which encodes the amino acid sequence of SEQ ID No. 9 or an amino acid sequence with at least 80% sequence identity to the sequence of SEQ ID No. 9, and a nucleotide sequence encoding the amino acid sequence for the heavy chain variable region comprises a nucleotide sequence which encodes the amino acid sequence of SEQ ID No. 10 or an amino acid sequence with at least 80% sequence identity to the sequence of SEQ ID No. 10.