公开(公告)号：US20160008292A1

公开(公告)日：2016-01-14

申请号：US14796332

申请日：2015-07-10

Applicant: Industrial Technology Research Institute

Inventor： Chih-Lung Chen ,  Wen-Yuan Hsieh ,  Chen-Hsuan Lin ,  Su-Yo Lin ,  Shin-Yi Huang ,  Yuan-Hung Hsu ,  Shian-Jy Wang ,  Hsin Jung Huang

IPC: A61K9/51 ,  A61K33/26

CPC classification number: A61K9/5146 ,  A61K33/26 ,  Y10S514/814 ,  Y10S977/773

Abstract: A method of treating a condition related to iron deficiency. The method includes steps of identifying a patient having a condition related to iron deficiency and administering an effective amount of biocompatible iron oxide nanoparticles to the patient. The biocompatible iron oxide nanoparticles each contains an iron oxide core that is covered by one or more biocompatible polymers, each of which has a polyethylene glycol group, a silane group, and a linker linking, via a covalent bond, the polyethylene glycol group and the silane group.

Abstract translation: 治疗与铁缺乏有关的病症的方法。 该方法包括鉴定具有与铁缺乏相关的病症的患者并向患者施用有效量的生物相容性氧化铁纳米颗粒的步骤。 生物相容的氧化铁纳米颗粒各自含有氧化铁芯，其被一种或多种生物相容性聚合物覆盖，所述聚合物各自具有聚乙二醇基团，硅烷基团和通过共价键连接聚乙二醇基团和 硅烷基。

公开(公告)号：US09492399B2

公开(公告)日：2016-11-15

申请号：US14796332

申请日：2015-07-10

Applicant: Industrial Technology Research Institute

Inventor： Chih-Lung Chen ,  Wen-Yuan Hsieh ,  Chen-Hsuan Lin ,  Su-Yo Lin ,  Shin-Yi Huang ,  Yuan-Hung Hsu ,  Shian-Jy Wang ,  Hsin Jung Huang

IPC: A61K9/51 ,  A61K33/26

CPC classification number: A61K9/5146 ,  A61K33/26 ,  Y10S514/814 ,  Y10S977/773

Abstract: A method of treating a condition related to iron deficiency. The method includes steps of identifying a patient having a condition related to iron deficiency and administering an effective amount of biocompatible iron oxide nanoparticles to the patient. The biocompatible iron oxide nanoparticles each contains an iron oxide core that is covered by one or more biocompatible polymers, each of which has a polyethylene glycol group, a silane group, and a linker linking, via a covalent bond, the polyethylene glycol group and the silane group.

Abstract translation: 治疗与铁缺乏有关的病症的方法。 该方法包括鉴定具有与铁缺乏相关的病症的患者并向患者施用有效量的生物相容性氧化铁纳米颗粒的步骤。 生物相容的氧化铁纳米颗粒各自含有氧化铁芯，其被一种或多种生物相容性聚合物覆盖，所述聚合物各自具有聚乙二醇基团，硅烷基团和通过共价键连接聚乙二醇基团和 硅烷基。

公开(公告)号：US08562953B2

公开(公告)日：2013-10-22

申请号：US13633485

申请日：2012-10-02

Applicant: Industrial Technology Research Institute

Inventor： Dhakshanamurthy Thirumalai ,  Chin-I Lin ,  Shian-Jy Wang

IPC: C08L73/00 ,  A61K9/00 ,  C07D407/00

CPC classification number: C08G83/003 ,  A61K49/124

Abstract: A dendritic polymer and a magnetic resonance imaging contrast agent employing the same. The magnetic resonance contrast agent includes the dendritic polymer according to the structure of SP-DZ-L)i)j or SP-DX-Z-L)i)j, wherein, S is cyclosilane moiety with j silicon oxygen residual groups, and j is not less than 2; P is CH2CH2Ol, and l is not less than 1; D is a C3-30 dendritic moiety having n oxygen residue, and n is not less than 3; X is C3-30 moiety having bi-functional groups; Z is a C3-20 moiety having a plurality of functional group; and L is a metal cation.

Abstract translation: 树突状聚合物和使用其的磁共振成像造影剂。 磁共振造影剂包括根据SP-DZ-L）i）j或SP-DX-ZL）i）j的结构的树枝状聚合物，其中S是具有j个硅氧残基的环硅烷部分，j是 不低于2; P是CH 2 CH 2 O，l不小于1; D是具有n个氧残基的C3-30树枝状部分，n不小于3; X是具有双官能团的C3-30部分; Z是具有多个官能团的C3-20部分; L是金属阳离子。

公开(公告)号：US20160008491A1

公开(公告)日：2016-01-14

申请号：US14796539

申请日：2015-07-10

Applicant: Industrial Technology Research Institute

Inventor： Chih-Lung Chen ,  Wen-Yuan Hsieh ,  Chen-Hsuan Lin ,  Shian-Jy Wang

IPC: A61K49/18

CPC classification number: A61K49/186 ,  A61K49/1848

Abstract: A method of tracking immune cells to detect immune response. The method including steps of identifying a patient having a disease associated with an organ; administering biocompatible magnetic nanoparticles into the blood stream of the patient; and obtaining a magnetic resonance image of the organ. The presence of hyperintense or hypointense spots in the magnetic resonance image indicates immune response in the patient.

Abstract translation: 一种跟踪免疫细胞以检测免疫反应的方法。 该方法包括鉴定患有与器官相关的疾病的患者的步骤; 将生物相容的磁性纳米颗粒施用到患者的血液中; 并获得器官的磁共振图像。 在磁共振图像中高信号或低信号点的存在表示患者的免疫应答。