公开(公告)号：US20160008292A1

公开(公告)日：2016-01-14

申请号：US14796332

申请日：2015-07-10

Applicant: Industrial Technology Research Institute

Inventor： Chih-Lung Chen ,  Wen-Yuan Hsieh ,  Chen-Hsuan Lin ,  Su-Yo Lin ,  Shin-Yi Huang ,  Yuan-Hung Hsu ,  Shian-Jy Wang ,  Hsin Jung Huang

IPC: A61K9/51 ,  A61K33/26

CPC classification number: A61K9/5146 ,  A61K33/26 ,  Y10S514/814 ,  Y10S977/773

Abstract: A method of treating a condition related to iron deficiency. The method includes steps of identifying a patient having a condition related to iron deficiency and administering an effective amount of biocompatible iron oxide nanoparticles to the patient. The biocompatible iron oxide nanoparticles each contains an iron oxide core that is covered by one or more biocompatible polymers, each of which has a polyethylene glycol group, a silane group, and a linker linking, via a covalent bond, the polyethylene glycol group and the silane group.

Abstract translation: 治疗与铁缺乏有关的病症的方法。 该方法包括鉴定具有与铁缺乏相关的病症的患者并向患者施用有效量的生物相容性氧化铁纳米颗粒的步骤。 生物相容的氧化铁纳米颗粒各自含有氧化铁芯，其被一种或多种生物相容性聚合物覆盖，所述聚合物各自具有聚乙二醇基团，硅烷基团和通过共价键连接聚乙二醇基团和 硅烷基。

公开(公告)号：US08956871B2

公开(公告)日：2015-02-17

申请号：US13713327

申请日：2012-12-13

Applicant: Industrial Technology Research Institute

Inventor： Pei-Ju Lin ,  Guilhem Tourniaire ,  Yi-Chen Chen ,  Kathryn Swindells ,  Bin-Ru She ,  Hsiang-Chun Hsu ,  Chih-Ching Liao ,  Su-Yo Lin

IPC: C12N5/00 ,  C12N5/0775 ,  C12N5/07 ,  C08F220/14 ,  C08F220/18 ,  C08F220/28 ,  C08F222/26 ,  C08F220/06

CPC classification number: C12N5/0031 ,  C08F220/06 ,  C08F220/14 ,  C08F220/18 ,  C08F220/28 ,  C08F222/26 ,  C12N5/0037 ,  C12N5/0068 ,  C12N2533/30

Abstract: The disclosure provides a cell culture system and a serum-free method for cultivating cells. The cell culture system includes a substratum, wherein the substratum has a surface. A polymer is disposed on the surface of the substratum, wherein the polymer is prepared by polymerizing a first monomer with a second monomer. The first monomer has a structure as represented by Formula (I), and the second monomer has a structure as represented by Formula (II): wherein, R1 is hydrogen or methyl; R2 is methyl, ethyl, or —CH2CH2OCH3; R3 is hydrogen or methyl; and, R4 is hydrogen, —CH2CH2OCOCHCHCOOH, —CH2CH2OCOCH2CH2COOH, or —CH2CH2COOH.

Abstract translation: 本公开提供了一种培养细胞的细胞培养系统和无血清方法。 细胞培养系统包括底物，其中底物具有表面。 聚合物设置在基底的表面上，其中聚合物通过使第一单体与第二单体聚合来制备。 第一单体具有由式（I）表示的结构，第二单体具有由式（II）表示的结构：其中，R 1为氢或甲基; R2是甲基，乙基或-CH2CH2OCH3; R3是氢或甲基; 和R 4是氢，-CH 2 CH 2 OCOCHCHCOOH，-CH 2 CH 2 OCOCH 2 CH 2 COOH或-CH 2 CH 2 COOH。

公开(公告)号：US09492399B2

公开(公告)日：2016-11-15

申请号：US14796332

申请日：2015-07-10

Applicant: Industrial Technology Research Institute

Inventor： Chih-Lung Chen ,  Wen-Yuan Hsieh ,  Chen-Hsuan Lin ,  Su-Yo Lin ,  Shin-Yi Huang ,  Yuan-Hung Hsu ,  Shian-Jy Wang ,  Hsin Jung Huang

IPC: A61K9/51 ,  A61K33/26

CPC classification number: A61K9/5146 ,  A61K33/26 ,  Y10S514/814 ,  Y10S977/773

Abstract: A method of treating a condition related to iron deficiency. The method includes steps of identifying a patient having a condition related to iron deficiency and administering an effective amount of biocompatible iron oxide nanoparticles to the patient. The biocompatible iron oxide nanoparticles each contains an iron oxide core that is covered by one or more biocompatible polymers, each of which has a polyethylene glycol group, a silane group, and a linker linking, via a covalent bond, the polyethylene glycol group and the silane group.

Abstract translation: 治疗与铁缺乏有关的病症的方法。 该方法包括鉴定具有与铁缺乏相关的病症的患者并向患者施用有效量的生物相容性氧化铁纳米颗粒的步骤。 生物相容的氧化铁纳米颗粒各自含有氧化铁芯，其被一种或多种生物相容性聚合物覆盖，所述聚合物各自具有聚乙二醇基团，硅烷基团和通过共价键连接聚乙二醇基团和 硅烷基。