公开(公告)号：US09777273B2

公开(公告)日：2017-10-03

申请号：US15322878

申请日：2015-08-05

申请人： Industrial Technology Research Institute ,  Academia Sinica

发明人： Yen-Ju Lin ,  Jui-Wen Huang ,  Fu-Tong Liu ,  Huan-Yuan Chen ,  Wei-Chen Hsieh

IPC分类号： C12N15/11 ,  C12N15/113

CPC分类号： C12N15/113 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3521

摘要： A small interfering RNA is provided. The small interfering RNA consists of a passenger strand and a guide strand, wherein the sequence of the passenger strand comprises the sequence of SEQ ID NO. 7, and the sequence of the guide strand comprises the sequence of SEQ ID NO. 8, wherein the small interfering RNA is capable of inhibiting galectin-12 expression.

公开(公告)号：US11286304B2

公开(公告)日：2022-03-29

申请号：US16653986

申请日：2019-10-15

申请人： Academia Sinica

发明人： Fu-Tong Liu ,  Hung-Lin Chen ,  Po-Cheng Chiang

IPC分类号： C07K16/28 ,  G01N33/50 ,  A61P17/06 ,  A61P35/00

摘要： Provided herein is a novel antibody exhibiting binding affinity and specificity to galectin-7. Also provided herein are methods for treating psoriasis or cancer in a subject by administering to the subject a drug selected with the aid of the present anti-galectin-7 antibody.

公开(公告)号：US09121021B2

公开(公告)日：2015-09-01

申请号：US14534466

申请日：2014-11-06

申请人： Academia Sinica

发明人： Fu-Tong Liu ,  Wei-Chen Hsieh ,  Ri-Yao Yang

IPC分类号： A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/113

CPC分类号： C12N15/113 ,  C12N2310/14

摘要： Methods for the treatment of a disorder characterized by excessive proliferation and/or lipid content of sebocytes are disclosed. In one embodiment of the invention, the method comprises administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a small molecule inhibitor targeted to galectin-12 or a nucleic acid-based inhibitor targeted to galectin-12 and a pharmaceutically acceptable carrier, wherein said inhibitor is a non-naturally occurring molecule and administration of said inhibitor produces a decrease in the proliferation and/or lipid content of the sebocytes. Methods for decreasing sebaceous gland size, inhibiting sebocyte proliferation, and/or inhibiting sebocyte lipid content are also disclosed.

摘要翻译： 公开了治疗以皮脂细胞过度增殖和/或脂质含量为特征的病症的方法。 在本发明的一个实施方案中，所述方法包括向有需要的受试者施用治疗有效量的药物组合物，其包含靶向半乳凝素-12的小分子抑制剂或靶向半乳凝素-12的核酸抑制剂和药学上 其中所述抑制剂是非天然存在的分子，并且所述抑制剂的施用会导致皮脂细胞的增殖和/或脂质含量的降低。 还公开了降低皮脂腺体积大小，抑制血细胞增殖和/或抑制血细胞脂质含量的方法。