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    SERPIN FUSION POLYPEPTIDES AND METHODS OF USE THEREOF
    3.
    发明申请
    SERPIN FUSION POLYPEPTIDES AND METHODS OF USE THEREOF 有权

    公开(公告)号：US20210024613A1

    公开(公告)日：2021-01-28

    申请号：US17066410

    申请日：2020-10-08

    申请人： InhibRx, Inc.

    发明人： Brendan P. ECKELMAN ,  John C. TIMMER ,  Peter L. NGUY ,  Grant B. GUENTHER ,  Quinn DEVERAUX

    IPC分类号： C07K14/81 ,  C07K14/715 ,  C07K16/24 ,  C07K14/525 ,  C07K14/76 ,  C07K16/40 ,  C07K14/765

    摘要： This invention relates to molecules, particularly polypeptides, more particularly fusion proteins that include a serpin polypeptide or an amino acid sequence that is derived from a serpin and second polypeptide comprising of at least one the following: an Fc polypeptide or an amino acid sequence that is derived from an Fc polypeptide; a cytokine targeting polypeptide or a sequence derived from a cytokine targeting polypeptide; a whey acidic protein (WAP) domain containing polypeptide or a sequence derived from a WAP containing polypeptide; and an albumin polypeptide or an amino acid sequence that is derived from a serum albumin polypeptide. This invention also relates to methods of using such molecules in a variety of therapeutic and diagnostic indications, as well as methods of producing such molecules.

    SERPIN FUSION POLYPEPTIDES AND METHODS OF USE THEREOF
    5.
    发明申请
    SERPIN FUSION POLYPEPTIDES AND METHODS OF USE THEREOF 有权

    公开(公告)号：US20220324944A1

    公开(公告)日：2022-10-13

    申请号：US17315511

    申请日：2021-05-10

    申请人： InhibRx, Inc.

    发明人： Brendan P. ECKELMAN ,  John C. TIMMER ,  Quinn DEVERAUX

    IPC分类号： C07K14/81 ,  C07K14/525 ,  C07K14/715 ,  C07K16/24

    摘要： This invention relates to molecules, particularly polypeptides, more particularly fusion proteins that include a serpin polypeptide or an amino acid sequence that is derived from a serpin and second polypeptide comprising of at least one the following: an Fc polypeptide or an amino acid sequence that is derived from an Fc polypeptide; a cytokine targeting polypeptide or a sequence derived from a cytokine targeting polypeptide; a WAP domain containing polypeptide or a sequence derived from a WAP containing polypeptide; and an albumin polypeptide or an amino acid sequence that is derived from a serum albumin polypeptide. This invention also relates to methods of using such molecules in a variety of therapeutic and diagnostic indications, as well as methods of producing such molecules.

    SERPIN FUSION POLYPEPTIDES AND METHODS OF USE THEREOF
    6.
    发明申请
    SERPIN FUSION POLYPEPTIDES AND METHODS OF USE THEREOF 有权

    公开(公告)号：US20210002352A1

    公开(公告)日：2021-01-07

    申请号：US16908271

    申请日：2020-06-22

    申请人： Inhibrx, Inc.

    发明人： Brendan P. ECKELMAN ,  John C. TIMMER ,  Peter L. NGUY ,  Grant B. GUENTHER ,  Quinn DEVERAUX

    IPC分类号： C07K14/81 ,  C07K14/715 ,  C07K16/24 ,  C07K14/525 ,  C07K14/76 ,  C07K16/40 ,  C07K14/765

    摘要： This invention relates to molecules, particularly polypeptides, more particularly fusion proteins that include a serpin polypeptide or an amino acid sequence that is derived from a serpin and second polypeptide comprising of at least one the following: an Fc polypeptide or an amino acid sequence that is derived from an Fc polypeptide; a cytokine targeting polypeptide or a sequence derived from a cytokine targeting polypeptide; a WAP domain containing polypeptide or a sequence derived from a WAP containing polypeptide; and an albumin polypeptide or an amino acid sequence that is derived from a serum albumin polypeptide. This invention also relates to methods of using such molecules in a variety of therapeutic and diagnostic indications, as well as methods of producing such molecules.

    MULTISPECIFIC POLYPEPTIDE CONSTRUCTS CONTAINING A CONSTRAINED CD3 BINDING DOMAIN AND A RECEPTOR BINDING REGION AND METHODS OF USING THE SAME
    7.
    发明申请
    MULTISPECIFIC POLYPEPTIDE CONSTRUCTS CONTAINING A CONSTRAINED CD3 BINDING DOMAIN AND A RECEPTOR BINDING REGION AND METHODS OF USING THE SAME 审中-公开

    公开(公告)号：US20200048350A1

    公开(公告)日：2020-02-13

    申请号：US16520293

    申请日：2019-07-23

    申请人： Inhibrx, Inc.

    发明人： Brendan P. ECKELMAN ,  Michael D. KAPLAN ,  Katelyn M. WILLIS ,  Quinn DEVERAUX ,  Kyle S. JONES ,  Rajay A. PANDIT ,  John C. TIMMER

    IPC分类号： C07K16/28

    摘要： The invention relates generally to multispecific polypeptides that bind at least CD3, a second antigen, and a receptor of a T cell, such as a costimulatory receptor or an inhibitory receptor, in which the multispecific polypeptide constructs are able to engage CD3. In some embodiments, the multispecific polypeptide constructs bind a costimulatory receptor and provide costimulatory binding activity. In some embodiments, the multispecific polypeptide constructs bind an inhibitory receptor and block inhibitory activity. In some aspects, the multispecific polypeptides have constrained CD3 binding and bind to or engage CD3 only upon binding to the second antigen, such as a tumor associated antigen. In some embodiments, the multispecific polypeptides contain cleavable linkers that, when cleaved, result in dual effector functions. Also provided are methods of making and using these multispecific polypeptides in a variety of therapeutic, diagnostic and prophylactic indications.