-
公开(公告)号：US20230331846A1
公开(公告)日：2023-10-19
申请号：US17922569
申请日：2021-05-03
申请人： Inhibrx, Inc.
IPC分类号： C07K16/28 , C12N5/0783
CPC分类号： C07K16/2818 , C12N5/0636 , A61K39/00 , C07K2317/20 , C07K2317/52 , C07K2317/569
摘要： Provided herein are VHH-containing polypeptides that bind canine PD-1. In some embodiments, VHH-containing polypeptides that bind and antagonize canine PD-1 are provided. Uses of the VHH-containing polypeptides are also provided.
-
2.发明公开公开(公告)号：US20230295336A1
公开(公告)日：2023-09-21
申请号：US18206354
申请日：2023-06-06
申请人： Inhibrx, Inc.
CPC分类号： C07K16/30 , A61P35/00 , C07K1/14 , C07K2317/31 , C07K2317/522 , C07K2317/55 , C07K2317/569 , C07K2317/622 , C07K2317/624 , C07K2317/64 , C07K2317/66 , C07K2317/732 , C07K2317/734 , C07K2317/75 , C07K2317/92
摘要： The invention relates generally to multispecific polypeptides having constrained CD3 binding. In some embodiments, components of the multispecific polypeptides are connected by a non-cleavable linker. Also provided are methods of making and using these multispecific polypeptides in a variety of therapeutic, diagnostic and prophylactic indications.
-
公开(公告)号：US20230235005A1
公开(公告)日：2023-07-27
申请号：US18002613
申请日：2021-07-01
申请人： Inhibrx, Inc.
发明人： John C. Timmer , Florian Sulzmaier , Katelyn M. Willis , Bryan R. Becklund , Brendan P. Eckelman
CPC分类号： C07K14/55 , A61K45/06 , A61K38/2013 , C07K2319/30
摘要： Provided herein are polypeptide comprising a modified IL-2, wherein the modified IL-2 has reduced affinity for the IL-2 receptor relative to wild type IL-2. In some embodiments, polypeptides comprising a modified IL-2 that bind and agonize activated T cells are provided. Uses of the polypeptides comprising a modified IL-2 are also provided.
-
公开(公告)号：US11566078B2
公开(公告)日：2023-01-31
申请号：US16601825
申请日：2019-10-15
申请人： Inhibrx, Inc.
发明人： Brendan P. Eckelman , John C. Timmer , Chelsie Macedo , Kyle S. Jones , Abrahim Hussain , Amir S. Razai , Bryan Becklund , Rajay Pandit , Mike Kaplan , Lucas Rascon , Quinn Deveraux
IPC分类号： C07K16/28
摘要： This invention relates generally to molecules that specifically engage 41BB, a member of the TNF receptor superfamily (TNFRSF). More specifically, this invention relates to multivalent and multispecific molecules that bind at least 41BB.
-
公开(公告)号：US20220323496A1
公开(公告)日：2022-10-13
申请号：US17608738
申请日：2020-05-07
申请人： 2SEVENTY BIO, INC. , INHIBRX, INC.
发明人： JORDAN JARJOUR , MARK POGSON , WAI-HANG LEUNG , LUCAS RASCON , ANGELICA SANABRIA , JOHN C. TIMMER , BRENDAN P. ECKELMAN
IPC分类号： A61K35/17 , A61P35/00 , C07K14/73 , C07K14/705 , C07K14/725 , C07K16/28 , C12N15/62
摘要： The present disclosure provides improved CLL-1 targeting polypeptides and compositions for adoptive T cell therapies for treating, preventing, or ameliorating at least one symptom of a cancer, infectious disease, autoimmune disease, inflammatory disease, and immunodeficiency, or condition associated therewith.
-
6.发明申请公开(公告)号：US20210317205A1
公开(公告)日：2021-10-14
申请号：US17170854
申请日：2021-02-08
申请人： InhibRx, Inc.
发明人： Brendan Eckelman , John Timmer , Amir Razai , Quinn Deveraux , Kyle Jones , Mark Lappe
IPC分类号： C07K16/28 , C07K14/705 , A61K45/06 , A61K39/395 , C07K16/30
摘要： This invention relates generally to monoclonal antibodies that recognize CD47, more specifically to CD47 antibodies that do not cause a significant level of agglutination of cells, red blood cell depletion, anemia, and/or platelet depletion, to methods of generating these antibodies, and to methods of using these monoclonal antibodies as therapeutics.
-
7.发明申请公开(公告)号：US20190330366A1
公开(公告)日：2019-10-31
申请号：US16380963
申请日：2019-04-10
申请人： Inhibrx, Inc.
摘要： The invention relates generally to multispecific polypeptides having constrained CD3 binding. In some embodiments, components of the multispecific polypeptides are connected by a non-cleavable linker. Also provided are methods of making and using these multispecific polypeptides in a variety of therapeutic, diagnostic and prophylactic indications.
-
公开(公告)号：US20230312716A1
公开(公告)日：2023-10-05
申请号：US18067504
申请日：2022-12-16
申请人： Inhibrx, Inc.
发明人： Kyle S. Jones , William Crago , Angelica Sanabria , Andrew Hollands , Jacob Gano , Milton Ma , John C. Timmer , Brendan P. Eckelman
CPC分类号： C07K16/2809 , A61K47/55 , C07K16/2818 , C07K16/283 , C07K16/2851 , A61K45/06
摘要： Provided herein are VHH-containing polypeptides that bind CD33. Uses of the VHH-containing polypeptides are also provided.
-
公开(公告)号：US20220324944A1
公开(公告)日：2022-10-13
申请号：US17315511
申请日：2021-05-10
申请人： InhibRx, Inc.
IPC分类号： C07K14/81 , C07K14/525 , C07K14/715 , C07K16/24
摘要： This invention relates to molecules, particularly polypeptides, more particularly fusion proteins that include a serpin polypeptide or an amino acid sequence that is derived from a serpin and second polypeptide comprising of at least one the following: an Fc polypeptide or an amino acid sequence that is derived from an Fc polypeptide; a cytokine targeting polypeptide or a sequence derived from a cytokine targeting polypeptide; a WAP domain containing polypeptide or a sequence derived from a WAP containing polypeptide; and an albumin polypeptide or an amino acid sequence that is derived from a serum albumin polypeptide. This invention also relates to methods of using such molecules in a variety of therapeutic and diagnostic indications, as well as methods of producing such molecules.
-
公开(公告)号：US11434297B2
公开(公告)日：2022-09-06
申请号：US16864478
申请日：2020-05-01
申请人： Inhibrx, Inc.
发明人： Chelsie Macedo , Kyle Jones , William Crago , Andrew Hollands , Milton Ma , John C. Timmer , Brendan P. Eckelman
摘要： Provided herein are VHH-containing polypeptides that bind CD123. Uses of the VHH-containing polypeptides are also provided.
-
-
-
-
-
-
-
-
-
搜索结果
55 条记录 (耗时 0.022 秒)
