公开(公告)号：US20210148797A1

公开(公告)日：2021-05-20

申请号：US17103900

申请日：2020-11-24

Applicant: InnovaPrep LLC

Inventor： Zachary Allen Packingham ,  Andrew Edward Page ,  David Scott Alburty ,  Steven Dale Graham ,  Alec Douglas Adolphson

IPC: G01N1/40 ,  B01D61/20 ,  B01D61/22 ,  B01D63/08

Abstract: The present disclosure provides for devices, systems and methods for fractionation and concentration of particles from a fluid sample. This includes a cartridge containing staged filters having porous surface in series of decreasing pore size for capture of particles from a fluid sample; and a permeate pressure source in fluid communication with the cartridge; wherein the particles are eluted from the porous surfaces and dispensed in a reduced fluid volume.

公开(公告)号：US20140231256A1

公开(公告)日：2014-08-21

申请号：US14058193

申请日：2013-10-18

Applicant: InnovaPrep LLC

Inventor： Zachary Allen Packingham ,  Andrew Edward Page ,  David Scott Alburty ,  Steven Dale Graham ,  Alec Douglas Adolphson

IPC: G01N1/40

CPC classification number: G01N1/405 ,  B01D61/20 ,  B01D61/22 ,  B01D63/082 ,  B01D63/088 ,  B01D2315/08 ,  B01D2319/06 ,  B01D2321/02 ,  G01N1/40 ,  G01N1/4055 ,  G01N1/4077 ,  G01N2001/4016 ,  G01N2001/4038 ,  G01N2001/4088

Abstract: The present disclosure provides for devices, systems and methods for fractionation and concentration of particles from a fluid sample. This includes a cartridge containing staged filters having porous surface in series of decreasing pore size for capture of particles from a fluid sample; and a permeate pressure source in fluid communication with the cartridge; wherein the particles are eluted from the porous surfaces and dispensed in a reduced fluid volume.

Abstract translation: 本公开提供了用于从流体样品分级和浓缩颗粒的装置，系统和方法。 这包括一个包含分级过滤器的筒，该过滤器具有一系列减小孔径的多孔表面，用于从流体样品捕获颗粒; 以及与所述盒流体连通的渗透压力源; 其中所述颗粒从所述多孔表面洗脱并以减少的流体体积分配。

公开(公告)号：US20210308664A1

公开(公告)日：2021-10-07

申请号：US17222951

申请日：2021-04-05

Applicant: INNOVAPREP LLC

Inventor： John D. Birkenholz ,  Andrew Edward Page ,  Zachary A. Packingham ,  David S. Alburty ,  Alec D. Adolphson ,  Steven Dale Graham ,  Michael F. Fischer

IPC: B01L3/02 ,  G01N1/14 ,  G01N1/40 ,  B01L3/00

Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrates biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect and identify. A single-use pipette tip includes fluid ports for aspirating the sample and connecting to a concentrating unit.