公开(公告)号：US20240000833A1

公开(公告)日：2024-01-04

申请号：US18309047

申请日：2023-04-28

申请人： Institut National de la Santé et de la Recherche Médicale ,  Universite d'Aix Marseille ,  Centre National de la Recherche Scientifique (CNRS) ,  Max Delbruck Center for Molecular Medicine (MDC)

发明人： Michael SIEWEKE ,  Kaaweh MOLAWI ,  Laufey GEIRSDOTTIR

IPC分类号： A61K35/15 ,  C12N5/0786 ,  A61P31/12 ,  A61P31/04 ,  A61P31/10 ,  A61P35/00

CPC分类号： A61K35/15 ,  C12N5/0645 ,  A61P31/12 ,  A61P31/04 ,  A61P31/10 ,  A61P35/00 ,  C12N2501/22

摘要： The present invention relates to methods for expanding a population of alveolar macrophages in a long term culture. In particular, an object of the present invention relates to a method of expanding a population of alveolar macrophages in a long term culture comprising culturing the population of alveolar macrophages in a culture medium supplemented with an amount of GM-CSF.

公开(公告)号：US20180360877A1

公开(公告)日：2018-12-20

申请号：US16060721

申请日：2016-12-08

申请人： INSERM (Institut National de la Sante et de la Recherche Medicale) ,  Universite d'Aix Marseille ,  Centre National de la Recherche Scientifque (CNRS) ,  Max Delbruck Center for Molecular Medicine (MDC)

发明人： Michael SIEWEKE ,  Kaaweh MOLAWI ,  Laufey GEIRSDOTTIR

IPC分类号： A61K35/15 ,  A61P35/00 ,  A61P31/12 ,  A61P31/04 ,  A61P31/10 ,  C12N5/0786

摘要： The present invention relates to methods for expanding a population of alveolar macrophages in a long term culture. In particular, an object of the present invention relates to a method of expanding a population of alveolar macrophages in a long term culture comprising culturing the population of alveolar macrophages in a culture medium supplemented with an amount of GM-CSF.