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1.发明申请公开(公告)号：US20190262306A1
公开(公告)日：2019-08-29
申请号：US16342610
申请日：2017-10-18
申请人： lnstitut National de Ia Sante et de Ia Recherche Medicale (INSERM) , Centre National de la Recherche Scientifique (CNRS) , Sorbonne Universite , Universite de Poitiers , Centre Hospitalier Universitaire de Poitiers
IPC分类号： A61K31/352 , A61K45/06 , A61P27/02 , A61P25/00
摘要： The present invention relates to a compound of the following general formula (I); or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug, particularly intended for inhibiting a programmed cell death route selected from the group consisting of ferroptosis, oxytosis and cellular necroptosis. The present invention also relates to a compound of general formula (I) for use as a drug for neuroprotection as well as for preventing and/or treating disorders associated with cellular necroptosis or ferroptosis. The present invention also relates to a pharmaceutical composition comprising a compound of general formula (I), or a pharmaceutically acceptable salt and/or solvate thereof. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.
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2.发明申请公开(公告)号：US20220096426A1
公开(公告)日：2022-03-31
申请号：US17547501
申请日：2021-12-10
申请人： Institut National de Ia Sante et de Ia Recherche Medicale (INSERM) , Centre National de la Recherche Scientifique (CNRS) , Sorbonne Universite , Universite de Poitiers , Centre Hospitalier Universitaire de Poitiers
IPC分类号： A61K31/352 , A61P27/02 , A61P25/00 , A61K45/06 , C07D311/20 , C07D311/54
摘要： The present invention relates to a compound of the following general formula (I): or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug, particularly intended for inhibiting a programmed cell death route selected from the group consisting of ferroptosis, oxytosis and cellular necroptosis. The present invention also relates to a compound of general formula (I) for use as a drug for neuroprotection as well as for preventing and/or treating disorders associated with cellular necroptosis or ferroptosis. The present invention also relates to a pharmaceutical composition comprising a compound of general formula (I), or a pharmaceutically acceptable salt and/or solvate thereof. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.
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3.发明授权公开(公告)号：US11224586B2
公开(公告)日：2022-01-18
申请号：US16342610
申请日：2017-10-18
申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) , Centre National de la Recherche Scientifique (CNRS) , Sorbonne Universite , Universite de Poitiers , Centre Hospitalier Universitaire de Poitiers
IPC分类号： A61K31/352 , A61K45/06 , A61P27/02 , A61P25/00 , C07D311/20 , C07D311/54
摘要： The present invention relates to a compound of the following general formula (I); or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug, particularly intended for inhibiting a programmed cell death route selected from the group consisting of ferroptosis, oxytosis and cellular necroptosis. The present invention also relates to a compound of general formula (I) for use as a drug for neuroprotection as well as for preventing and/or treating disorders associated with cellular necroptosis or ferroptosis. The present invention also relates to a pharmaceutical composition comprising a compound of general formula (I), or a pharmaceutically acceptable salt and/or solvate thereof. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.
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4.发明授权公开(公告)号：US11819492B2
公开(公告)日：2023-11-21
申请号：US17547501
申请日：2021-12-10
申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) , Centre National de la Recherche Scientifique (CNRS) , Sorbonne Universite , Universite de Poitiers , Centre Hospitalier Universitaire de Poitiers
IPC分类号： A61K31/352 , A61P27/02 , A61P25/00 , A61K45/06 , C07D311/20 , C07D311/54
CPC分类号： A61K31/352 , A61K45/06 , A61P25/00 , A61P27/02 , C07D311/20 , C07D311/54
摘要： The present invention relates to a compound of the following general formula (I):
or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug, particularly intended for inhibiting a programmed cell death route selected from the group consisting of ferroptosis, oxytosis and cellular necroptosis. The present invention also relates to a compound of general formula (I) for use as a drug for neuroprotection as well as for preventing and/or treating disorders associated with cellular necroptosis or ferroptosis. The present invention also relates to a pharmaceutical composition comprising a compound of general formula (I), or a pharmaceutically acceptable salt and/or solvate thereof. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.-
公开(公告)号：US10426758B2
公开(公告)日：2019-10-01
申请号：US15768388
申请日：2016-10-13
申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) , Centre National de la Recherche Scientifique (CNRS) , Universite De Poitiers , Sorbonne Universite , Universite Claude Bernard Lyon 1
发明人： Marie-Thérèse Dimanche-Boitrel , Stéphane Bach , Claire Delehouze , Yvette Mettey , Peter Goekjian , Arnaud Comte
IPC分类号： A61K31/437 , C07D471/04 , A01N1/02 , A61P9/10 , A61P1/16 , A61P1/00
摘要： The present invention relates to a compound of the following general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as inhibitor of cellular necroptosis. The present invention also relates to a pharmaceutical composition comprising a compound of general formula (I), or a pharmaceutically acceptable salt and/or solvate thereof, for use for preventing and/or treating disorders associated with cellular necroptosis. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.
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6.发明申请公开(公告)号：US20180325876A1
公开(公告)日：2018-11-15
申请号：US15768388
申请日：2016-10-13
申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) , Centre National de la Recherche Scientifique (CNRS) , Universite De Poitiers , Sorbonne Universite , Universite Claude Bernard Lyon 1
发明人： Marie-Thérèse Dimanche-Boitrel , Stéphane Bach , Claire Delehouze , Yvette Mettey , Peter Goekjian , Arnaud Comte
IPC分类号： A61K31/437 , A01N1/02 , A61P1/16 , A61P9/10
CPC分类号： A61K31/437 , A01N1/0226 , A61P1/00 , A61P1/16 , A61P9/10 , C07D471/04
摘要： The present invention relates to a compound of the following general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as inhibitor of cellular necroptosis. The present invention also relates to a pharmaceutical composition comprising a compound of general formula (I), or a pharmaceutically acceptable salt and/or solvate thereof, for use for preventing and/or treating disorders associated with cellular necroptosis. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.
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![Substituted pyrrolo[2,3-b]pyridines as inhibitors of cellular necroptosis](/abs-image/US/2019/10/29/US10457678B2/abs.jpg.150x150.jpg)
公开(公告)号：US10457678B2
公开(公告)日：2019-10-29
申请号：US15768395
申请日：2016-10-13
申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) , Centre National de la Recherche Scientifique (CNRS) , Sorbonne Universite , Universite Claude Bernard Lyon 1
发明人： Marie-Thérèse Dimanche-Boitrel , Stéphane Bach , Claire Delehouze , Peter Goekjian , Arnaud Comte
IPC分类号： A61K31/437 , C07D471/04
摘要： The present invention relates to new N1- and N7-substituted sibiriline derivatives of the following general formula (I): (I) or a pharmaceutically acceptable salt and/or solvate thereof, notably for use as drug, in particular for use as inhibitor of cellular necroptosis. The present invention also relates to a pharmaceutical composition comprising such a compound and processes to prepare such a compound. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.
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8.发明申请公开(公告)号：US20180312502A1
公开(公告)日：2018-11-01
申请号：US15768395
申请日：2016-10-13
申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) , Centre National de la Recherche Scientifique (CNRS) , Sorbonne Universite , Universite Claude Bernard Lyon 1
发明人： Marie-Thérèse Dimanche-Boitrel , Stéphane Bach , Claire Delehouze , Peter Goekjian , Arnaud Comte
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates to new N1- and N7-substituted sibiriline derivatives of the following general formula (I): (I) or a pharmaceutically acceptable salt and/or solvate thereof, notably for use as drug, in particular for use as inhibitor of cellular necroptosis. The present invention also relates to a pharmaceutical composition comprising such a compound and processes to prepare such a compound. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.
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