公开(公告)号：US20190233405A1

公开(公告)日：2019-08-01

申请号：US16303641

申请日：2017-05-23

申请人： Institute of Materia Medica, Chinese Academy of Medial Sciences

发明人： Zhiqiang Feng ,  Xiaoguang Chen ,  Yang Yang ,  Chuan Zhou ,  Fangfang Lai ,  Ming Ji ,  Xiaofeng Jin ,  Nina Xue ,  Yi Zheng ,  Hao Chen ,  Ling Li

IPC分类号： C07D407/12 ,  A61P35/00 ,  C07C235/34 ,  C07C233/36 ,  C07C229/36 ,  C07C211/29 ,  C07D265/30 ,  C07D221/00

CPC分类号： C07D407/12 ,  A61K31/165 ,  A61K31/277 ,  A61K31/36 ,  A61P35/00 ,  C07C211/29 ,  C07C229/36 ,  C07C233/36 ,  C07C235/34 ,  C07C255/54 ,  C07C311/05 ,  C07D221/00 ,  C07D265/30 ,  C07D319/18 ,  C07D405/12

摘要： The present invention discloses a phenylate derivative, a preparation method therefor, and a pharmaceutical composition and uses thereof. Specifically, the invention relates to phenylate derivatives represented by formula (I), a pharmaceutically-acceptable salt thereof, a stereoisomer thereof, a preparation method therefor, a pharmaceutical composition containing the one or more compounds, and uses of the compounds in treating diseases related to PD-1/PD-L1 signal channels, such as cancers, infectious diseases and autoimmune diseases.