专利检索 ap:("Institute of Process Engineering, Chinese Academy of Sciences") AND inv:"Yalu YAN" 第 1 页

1.

发明公开
Sugar Chain and Compositions Thereof and Use Thereof in Prevention and/or Treatment of Coronavirus Infection 审中-公开

公开(公告)号：US20230212210A1

公开(公告)日：2023-07-06

申请号：US17759251

申请日：2021-07-26

申请人： Institute of Process Engineering, Chinese Academy of Sciences

发明人： Yuguang DU , Jianjun LI , Yueqiang XU , Zhuo WANG , Dongdong LIU , Yalu YAN , Qi WANG , Xin YOU , Xiaohui DU

IPC分类号： C07H13/04 , C08B37/00 , A61P31/14

CPC分类号： C07H13/04 , C08B37/0063 , A61P31/14

摘要： The present application belongs to the field of life health, and discloses a sugar chain and a composition thereof, and use in the prevention and/or treatment of coronavirus infection. The sugar chain contains any one or more of Neu5Acα2-N1Gal building blocks, and/or any one or more of xFuc-N1Gal-N1(xFuc-N1)GlcNAc building blocks, at the non-reducing end, where, x=0 or 1, and N1=1, 2, 3, 4 or 6. A glycosidic bond formed between Neu5Ac and Gal is an α2 glycosidic bond. In the xFuc-N1Gal-N1(xFuc-N1)GlcNAc building blocks, a glycosidic bond formed between any two adjacent monosaccharides is an α1 or β1 glycosidic bond. The specific building block contained at the non-reducing end of the sugar chain blocks the binding of the virus to the host, thereby blocking virus invasion and infection of the respiratory tract/lung, and achieving the specific prevention and treatment.