-
公开(公告)号：US20150141635A1
公开(公告)日：2015-05-21
申请号：US14578399
申请日：2014-12-20
发明人： Scott Rose , Mark A. Behlke , Richard Owczarzy , Joseph A. Walder , Derek M. Thomas , Michael R. Marvin
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6832 , C07H21/04 , C12Q1/6818 , C12Q1/6851 , G01N33/5308 , G01N33/542 , C12Q2525/185 , C12Q2525/197 , C12Q2565/101
摘要： A composition comprising an oligonucleotide having the structure 5′-Y1-L1-X-L2-Y2-3′. Y1 comprises a sequence of one or more DNA or RNA nucleotides, including a first nucleotide N1 having a 3′ phosphate covalently linked to L1. Y2 comprises a sequence of one or more DNA or RNA nucleotides, including a second nucleotide N2 having a 5′ phosphate covalently linked to L2. L1 and L2 each independently are a direct bond or a C1-C7 alkyl, alkynyl, alkenyl, heteroalkyl, substituted alkyl, aryl, heteroaryl, substituted aryl, cycloalkyl, alkylaryl, or alkoxyl group. X is R1 is a hydrogen or a C1-C8 alkyl. M is a label or ligand comprising a fused polycyclic aromatic moiety.
摘要翻译： 包含具有结构5'-Y1-L1-X-L2-Y2-3'的寡核苷酸的组合物。 Y1包含一个或多个DNA或RNA核苷酸的序列，包括与L1共价连接的3'磷酸的第一核苷酸N1。 Y2包含一个或多个DNA或RNA核苷酸的序列，包括与L2共价连接的5'磷酸二酯的第二核苷酸N2。 L 1和L 2各自独立地为直接键或C 1 -C 7烷基，炔基，烯基，杂烷基，取代的烷基，芳基，杂芳基，取代的芳基，环烷基，烷基芳基或烷氧基。 X是R 1是氢或C 1 -C 8烷基。 M是包含稠合多环芳族部分的标记或配体。
-
公开(公告)号：US09234233B2
公开(公告)日：2016-01-12
申请号：US14578399
申请日：2014-12-20
发明人： Scott Rose , Mark A. Behlke , Richard Owczarzy , Joseph A. Walder , Derek M. Thomas , Michael R. Marvin
CPC分类号： C12Q1/6832 , C07H21/04 , C12Q1/6818 , C12Q1/6851 , G01N33/5308 , G01N33/542 , C12Q2525/185 , C12Q2525/197 , C12Q2565/101
摘要： A composition comprising an oligonucleotide having the structure 5′-Y1-L1-X-L2-Y2-3′. Y1 comprises a sequence of one or more DNA or RNA nucleotides, including a first nucleotide N1 having a 3′ phosphate covalently linked to L1. Y2 comprises a sequence of one or more DNA or RNA nucleotides, including a second nucleotide N2 having a 5′ phosphate covalently linked to L2. L1 and L2 each independently are a direct bond or a C1-C7 alkyl, alkynyl, alkenyl, heteroalkyl, substituted alkyl, aryl, heteroaryl, substituted aryl, cycloalkyl, alkylaryl, or alkoxyl group. X is R1 is a hydrogen or a C1-C8 alkyl. M is a label or ligand comprising a fused polycyclic aromatic moiety.
摘要翻译： 包含具有结构5'-Y1-L1-X-L2-Y2-3'的寡核苷酸的组合物。 Y1包含一个或多个DNA或RNA核苷酸的序列，包括与L1共价连接的3'磷酸的第一核苷酸N1。 Y2包含一个或多个DNA或RNA核苷酸的序列，包括与L2共价连接的5'磷酸二酯的第二核苷酸N2。 L 1和L 2各自独立地为直接键或C 1 -C 7烷基，炔基，烯基，杂烷基，取代的烷基，芳基，杂芳基，取代的芳基，环烷基，烷基芳基或烷氧基。 X是R 1是氢或C 1 -C 8烷基。 M是包含稠合多环芳族部分的标记或配体。
-
搜索结果
2 条记录 (耗时 0.015 秒)
