公开(公告)号：US20220372483A1

公开(公告)日：2022-11-24

申请号：US17836265

申请日：2022-06-09

Applicant: Intellia Therapeutics, Inc.

Inventor： Seth C. Alexander ,  Sabin Mulepati ,  Matthew Roy

IPC: C12N15/113 ,  C12N9/22

Abstract: This disclosure relates to modified guide RNAs having improved in vitro and in vivo activity in gene editing methods.

公开(公告)号：US20210087568A1

公开(公告)日：2021-03-25

申请号：US17111769

申请日：2020-12-04

Applicant: Intellia Therapeutics, Inc.

Inventor： Amy Madison Rhoden Smith ,  Seth C. Alexander ,  Duncan Brown ,  Robert Brown ,  Adhiraj Lanba ,  Rebecca Lescarbeau ,  Reynald Michael Lescarbeau ,  Rubina Parmar ,  Matthew Roy ,  Paige Salerno ,  Jessica Lynn Seitzer

IPC: C12N15/113 ,  C12N9/22

Abstract: This disclosure relates to modified guide RNAs having improved in vitro and in vivo activity in gene editing methods.