公开(公告)号：US20220372483A1

公开(公告)日：2022-11-24

申请号：US17836265

申请日：2022-06-09

Applicant: Intellia Therapeutics, Inc.

Inventor： Seth C. Alexander ,  Sabin Mulepati ,  Matthew Roy

IPC: C12N15/113 ,  C12N9/22

Abstract: This disclosure relates to modified guide RNAs having improved in vitro and in vivo activity in gene editing methods.

公开(公告)号：US11697806B2

公开(公告)日：2023-07-11

申请号：US16828615

申请日：2020-03-24

Applicant: Intellia Therapeutics, Inc.

Inventor： Christian Dombrowski ,  Jonathan Douglas Finn ,  Amy Madison Rhoden Smith ,  Seth C. Alexander

IPC: C12N15/11 ,  C12N9/22 ,  A61K9/51 ,  C12N15/88 ,  C12N15/85

CPC classification number: C12N9/22 ,  A61K9/5123 ,  C12N15/11 ,  C12N15/111 ,  C12N15/85 ,  C12N15/88 ,  C12N2310/20 ,  C12N2320/32 ,  C12N2800/80

Abstract: Compositions and methods for gene editing. In some embodiments, a polynucleotide encoding Cas9 is provided that can provide one or more of improved editing efficiency, reduced immunogenicity, or other benefits.

公开(公告)号：US20240150761A1

公开(公告)日：2024-05-09

申请号：US18532127

申请日：2023-12-07

Applicant: Intellia Therapeutics, Inc.

Inventor： Sabin Mulepati ,  Rubina Giare Parmar ,  Lindsey Jean Stretz ,  Michelle Young ,  Jasmine Josephine Bonanno ,  Seth C. Alexander

IPC: C12N15/113 ,  A61K48/00 ,  C12N9/22

CPC classification number: C12N15/113 ,  A61K48/005 ,  C12N9/22 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/533

Abstract: This disclosure relates to modified guide RNAs comprising an internal linker for in vitro and in vivo gene editing methods.

公开(公告)号：US20240124897A1

公开(公告)日：2024-04-18

申请号：US18362867

申请日：2023-07-31

Applicant: Intellia Therapeutics, Inc.

Inventor： Yong Chang ,  Seth C. Alexander ,  Kristy M. Wood ,  Arti Mahendra Prakash Kanjolia ,  Shobu Odate ,  Jessica Lynn Seitzer ,  Reynald Michael Lescarbeau ,  Walter Strapps

IPC: C12N15/90 ,  C12N9/22 ,  C12N15/11

CPC classification number: C12N15/907 ,  C12N9/22 ,  C12N15/11 ,  A61K38/00 ,  C12N2310/20

Abstract: Compositions and methods for editing, e.g., introducing double-stranded breaks, within the TTR gene are provided. Compositions and methods for treating subjects having amyloidosis associated with transthyretin (ATTR), are provided.

公开(公告)号：US20230012687A1

公开(公告)日：2023-01-19

申请号：US17486039

申请日：2021-09-27

Applicant: Intellia Therapeutics, Inc.

Inventor： Bradley Andrew Murray ,  Christian Dombrowski ,  Seth C. Alexander

IPC: C12N15/67 ,  C12N9/22 ,  C12N15/90 ,  C12N15/88 ,  C12N15/11

Abstract: Compositions and methods for gene editing. In some embodiments, a polynucleotide encoding Cas9 is provided that can provide one or more of improved editing efficiency, reduced immunogenicity, or other benefits.

公开(公告)号：US20240076636A1

公开(公告)日：2024-03-07

申请号：US18132278

申请日：2023-04-07

Applicant: Intellia Therapeutics, Inc.

Inventor： Christian Dombrowski ,  Jonathan Douglas Finn ,  Amy Madison Rhoden Smith ,  Seth C. Alexander

IPC: C12N9/22 ,  A61K9/51 ,  C12N15/11 ,  C12N15/85 ,  C12N15/88

CPC classification number: C12N9/22 ,  A61K9/5123 ,  C12N15/11 ,  C12N15/111 ,  C12N15/85 ,  C12N15/88 ,  C12N2310/20 ,  C12N2320/32 ,  C12N2800/80

Abstract: Compositions and methods for gene editing. In some embodiments, a polynucleotide encoding Cas9 is provided that can provide one or more of improved editing efficiency, reduced immunogenicity, or other benefits.

公开(公告)号：US20230044994A1

公开(公告)日：2023-02-09

申请号：US17486735

申请日：2021-09-27

Applicant: Intellia Therapeutics, Inc.

Inventor： Yong Chang ,  Seth C. Alexander ,  Kristy M. Wood ,  Arti Mahendra Prakash Kanjolia ,  Shobu Odate ,  Jessica Lynn Seitzer ,  Reynald Michael Lescarbeau ,  Walter Strapps

IPC: C12N15/90 ,  C12N9/22 ,  C12N15/11

Abstract: Compositions and methods for editing, e.g., introducing double-stranded breaks, within the TTR gene are provided. Compositions and methods for treating subjects having amyloidosis associated with transthyretin (ATTR), are provided.

公开(公告)号：US20210087568A1

公开(公告)日：2021-03-25

申请号：US17111769

申请日：2020-12-04

Applicant: Intellia Therapeutics, Inc.

Inventor： Amy Madison Rhoden Smith ,  Seth C. Alexander ,  Duncan Brown ,  Robert Brown ,  Adhiraj Lanba ,  Rebecca Lescarbeau ,  Reynald Michael Lescarbeau ,  Rubina Parmar ,  Matthew Roy ,  Paige Salerno ,  Jessica Lynn Seitzer

IPC: C12N15/113 ,  C12N9/22

Abstract: This disclosure relates to modified guide RNAs having improved in vitro and in vivo activity in gene editing methods.