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公开(公告)号：US11930818B2
公开(公告)日：2024-03-19
申请号：US16738517
申请日：2020-01-09
发明人： Victoria A. Piunova , Noah Frederick Fine Nathel , James L. Hedrick , Yi Yan Yang , Willy Chin , Zhi Xiang Voo
IPC分类号： A01N47/06 , A01N25/00 , C08G64/02 , C08G64/16 , C08G64/42 , C09D5/14 , C09D169/00 , C08G83/00
CPC分类号： A01N47/06 , A01N25/00 , C08G64/0241 , C08G64/1641 , C08G64/1658 , C08G64/42 , C09D5/14 , C09D169/00 , C08G83/004 , A01N25/00 , A01N43/90 , A01N59/00
摘要： Techniques regarding star polymers with enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a core that can have a singlet oxygen generator and that can generate a singlet oxygen species upon irradiation with light. The polymer can also comprise a plurality of polycarbonate arms covalently bonded to the core. The plurality of polycarbonate arms can be degradable and can comprise a cation. Further, the plurality of polycarbonate arms can have antimicrobial functionality.
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公开(公告)号：US20220009966A1
公开(公告)日：2022-01-13
申请号：US17487225
申请日：2021-09-28
发明人： Payel Das , Flaviu Cipcigan , James L. Hedrick , Yi Yan Yang , Kahini Wadhawan , Inkit Padhi , Enara C Vijil , Pang Kern Jeremy Tan
IPC分类号： C07K7/08
摘要： De novo, artificial intelligence (AI) designed antimicrobial peptides (AMPs), antibacterial products comprising the AMPs and methods for treating bacterial infections using the products are provided. In one or more embodiments, the AMPs were designed using conditional latent attribute space sampling (CLaSS). The AMPs comprise up to twenty natural amino acids in length, including one with twelve and another with thirteen natural amino acids in length. The AMPs demonstrate low-toxicity and show high antimicrobial potency against diverse pathogens including multi-medication-resistant Gram negative Klebsiella pneumoniae.
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3.发明授权公开(公告)号：US11167036B2
公开(公告)日：2021-11-09
申请号：US16201155
申请日：2018-11-27
IPC分类号： A61K47/59 , A61K31/4188 , A61K31/155 , A61K47/55
摘要： The subject disclosure is directed to techniques for enhancing the selectivity and efficacy of therapeutic polymers against a broad spectrum of pathogens and cancer cell lines. According to an embodiment, a method is provided that comprises forming a therapeutic polymer based on polymerization of a plurality of therapeutic monomers, wherein the therapeutic polymer provides a therapeutic functionality. The method further comprises attaching biotin to the therapeutic polymer, resulting in a biotin-functionalized therapeutic polymer, wherein the biotin-functionalized therapeutic polymer provides greater therapeutic efficacy relative to the therapeutic polymer.
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公开(公告)号：US11006628B2
公开(公告)日：2021-05-18
申请号：US16744868
申请日：2020-01-16
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Yi Yan Yang
IPC分类号： A01N25/10 , A01N37/26 , A01N43/50 , A01N47/44 , C07C279/10 , C08L79/02 , C08G69/26 , C08G73/02 , C08L101/00 , A61Q17/00
摘要： Techniques regarding chemical compounds with antimicrobial functionality are provided. For example, one or more embodiments describe herein can comprise a monomer that can comprise a molecular backbone. The molecular backbone can comprise a bis(urea)guanidinium structure covalently bonded to a functional group, which can comprise a radical. Also, the monomer can have supramolecular assembly functionality.
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公开(公告)号：US10953039B2
公开(公告)日：2021-03-23
申请号：US16144040
申请日：2018-09-27
发明人： James L. Hedrick , Simone Bianco , Mark Kunitomi , Yi Yan Yang , Xin Ding , Chuan Yang , Zhen Chang Liang , Paola Florez de Sessions , Balamurugan Periaswamy
IPC分类号： A61K31/785 , A61P31/04 , A61K31/407 , A61K31/496 , A61K31/7052 , A61K31/43
摘要： Techniques regarding treating one or more microbe infections with combination therapy are provided. For example, one or more embodiments described herein can comprise a method, which can comprise enhancing an antimicrobial activity of an antibiotic by a combination therapy. The combination therapy can comprise the antibiotic and a polycarbonate polymer functionalized with a guanidinium functional group.
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公开(公告)号：US10752787B2
公开(公告)日：2020-08-25
申请号：US16675754
申请日：2019-11-06
发明人： Amos Cahan , Xin Ding , Mareva B. Fevre , James L. Hedrick , Zhen Chang Liang , Nathaniel H. Park , Theodore G. van Kessel , Rudy J. Wojtecki , Yi Yan Yang
IPC分类号： C09D5/14 , C09D161/22 , A01N33/08 , A01N31/16 , C09D181/02 , A01N33/10 , B05D1/02 , B05D1/00 , B29C39/38 , B29C39/26 , A01N25/10 , C09D5/16 , G03F7/00 , B05D5/02
摘要： Embodiments are directed to a method of making an antifouling and bactericidal coating with tailorable surface topology. The method includes depositing a layer of branched polyethyleneimine (BPEI) and diamino-functionalized poly(propylene oxide) (PPO) in a mixture of water and organic solvent on a substrate to form a layer of BPEI/PPO. The method includes depositing a layer of glyoxal in a water-containing solution on the layer of BPEI/PPO. The method further includes curing the layer of BPEI/PPO and layer of glyoxal to form a homogenous, glyoxal crosslinked BPEI/PPO coating, where the curing induces local precipitation and alteration of the glyoxal crosslinked BPEI/PPO coating to provide a textured surface.
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公开(公告)号：US20200221692A1
公开(公告)日：2020-07-16
申请号：US16744868
申请日：2020-01-16
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Yi Yan Yang
IPC分类号： A01N25/10 , A01N43/50 , A01N37/26 , C07C279/10 , C08L79/02 , C08G69/26 , C08G73/02 , A01N47/44 , C08L101/00
摘要： Techniques regarding chemical compounds with antimicrobial functionality are provided. For example, one or more embodiments describe herein can comprise a monomer that can comprise a molecular backbone. The molecular backbone can comprise a bis(urea)guanidinium structure covalently bonded to a functional group, which can comprise a radical. Also, the monomer can have supramolecular assembly functionality.
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公开(公告)号：US10687530B2
公开(公告)日：2020-06-23
申请号：US15839388
申请日：2017-12-12
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Yi Yan Yang , Mu San Zhang
IPC分类号： A01N37/18 , C08G69/40 , A01N33/12 , A01N43/50 , C08L101/00
摘要： Techniques regarding ionene and/or polyionene compositions with antimicrobial functionality and enhanced hydrophilicity are provided. For example, one or more embodiments can regard a chemical compound that can comprise an ionene unit, which can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. The ionene unit can have antimicrobial functionality. Further, the chemical compound can comprise a hydrophilic functional group covalently bonded to the ionene unit. Also, the chemical compound can have carbohydrate mimetic functionality.
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公开(公告)号：US10561146B2
公开(公告)日：2020-02-18
申请号：US15824250
申请日：2017-11-28
发明人： Willy Chin , James L. Hedrick , Noah Frederick Fine Nathel , Victoria A. Piunova , Zhi Xiang Voo , Yi Yan Yang
摘要： Techniques regarding star polymers with enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a core that can have a singlet oxygen generator and that can generate a singlet oxygen species upon irradiation with light. The polymer can also comprise a plurality of polycarbonate arms covalently bonded to the core. The plurality of polycarbonate arms can be degradable and can comprise a cation. Further, the plurality of polycarbonate arms can have antimicrobial functionality.
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公开(公告)号：US10507267B2
公开(公告)日：2019-12-17
申请号：US15496473
申请日：2017-04-25
发明人： Amos Cahan , Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Theodore G. van Kessel , Rudy J. Wojtecki , Yi Yan Yang
IPC分类号： C09D183/04 , A61L31/10 , A61L29/08 , A61L29/16 , A61L31/16 , A61L27/34 , A61L27/54 , A61L27/50 , C08G75/20 , C09D181/06 , C08G75/0227 , C08G75/0213 , C09D181/02 , B05D5/00 , B05D1/00 , B05D3/02
摘要： Antibacterial coatings and methods of making the antibacterial coatings are described herein. In particular, a method for forming an organocatalyzed polythioether coating is provided in which a first solution including a bis-silylated dithiol and a fluoroarene is prepared. A second solution including an organocatalyst is prepared. The first solution and the second solution are mixed to form a mixed solution. The mixed solution is applied to a substrate, and the substrate is cured.
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