公开(公告)号：US20210107874A1

公开(公告)日：2021-04-15

申请号：US16496514

申请日：2018-03-30

Applicant: Intervet Inc.

Inventor： Michael Berger ,  Hans Peter Niedermann ,  Marcus Knell ,  Anne Lehay ,  Angelique Duval ,  Anne-Laure Morer ,  Susi Alteheld

IPC: C07D213/74 ,  A61K47/10 ,  A61K9/08 ,  A61K47/02 ,  A61K47/22 ,  A61K47/12 ,  A61K47/38 ,  A61K47/18 ,  A61K47/14 ,  A61K47/20 ,  A61K47/26

Abstract: The present invention is directed to a salt of a compound of formula (I), R1 is halogen or methyl; X is methyl, OR2, or SR2; Y1, Y2 is CR3 or N, and one of Y1, Y2 is N and one of Y1, Y2 is CR3; R2 is methyl or ethyl; R3 is hydrogen or methyl, wherein the salt is chosen from the group 10 consisting of malate salt, citrate salt, tartrate salt, oxalate salt, fumarate salt, lactate salt, glucoronate salt, oxoglucoronate salt, ethanesulfonate salt, and succinate salt. The present invention is further related to a pharmaceutical formulation comprising the salt of the invention wherein the base compound is present in an amount of 2-30% (w/v) and having a pH value of at least 3.7 and to methods of treatment using the salt of the invention.